LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 3 von insgesamt 3

Suchoptionen

  1. Artikel: The potential for reducing the impact of aviation on climate

    Green, John E

    Technology analysis & strategic management Vol. 21, No. 1 , p. 39-59

    2009  Band 21, Heft 1, Seite(n) 39–59

    Verfasserangabe J. E. Green
    Schlagwörter Immissionsschutz ; Luftverkehr ; Klimawandel ; Flugzeugantrieb
    Sprache Englisch
    Umfang Ill., graph. Darst.
    Verlag Routledge, Taylor & Francis
    Erscheinungsort Abingdon, Oxfordshire
    Dokumenttyp Artikel
    ZDB-ID 32138-2
    Datenquelle ECONomics Information System

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Dynamin function is important for chemokine receptor-induced cell migration.

    Jacques, Richard O / Mills, Shirley C / Cazzonatto Zerwes, Paula / Fagade, Feyisope O / Green, John E / Downham, Scott / Sexton, Darren W / Mueller, Anja

    Cell biochemistry and function

    2015  Band 33, Heft 6, Seite(n) 407–414

    Abstract: The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis ( ... ...

    Abstract The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis (CTX). Our aim was to investigate the signalling pathways involved in CC and CXC receptor-mediated cell migration. Inhibition of dynamin I and II GTPase with dynasore completely inhibited CCL3-stimulated CTX in THP-1 cells, whereas the dynasore analogue Dyngo-4a, which is a more potent inhibitor, showed reduced ability to inhibit CC chemokine-induced CTX. In contrast, dynasore was not able to block cell migration via CXCR4. The same activation/inhibition pattern was verified in activated T lymphocytes for different CC and CXC chemokines. Cell migration induced by CC and CXC receptors does not rely on active internalization processes driven by dynamin because the blockade of internalization does not affect migration, but it might rely on dynamin interaction with the cytoskeleton. We identify here a functional difference in how CC and CXC receptor migration is controlled, suggesting that specific signalling networks are being employed for different receptor classes and potentially specific therapeutic targets to prevent receptor migration can be identified.
    Mesh-Begriff(e) Calcium/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Chemokine CCL3/metabolism ; Chemotaxis/drug effects ; Dynamins/antagonists & inhibitors ; Dynamins/chemistry ; Dynamins/metabolism ; Humans ; Hydrazones/pharmacology ; Monocytes/cytology ; Monocytes/metabolism ; Naphthols/pharmacology ; Receptors, CCR5/metabolism ; Receptors, CXCR4/antagonists & inhibitors ; Receptors, CXCR4/metabolism ; Signal Transduction/drug effects ; T-Lymphocytes/metabolism
    Chemische Substanzen CCR5 protein, human ; Chemokine CCL3 ; Hydrazones ; N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide ; Naphthols ; Receptors, CCR5 ; Receptors, CXCR4 ; dyngo-4a ; Dynamins (EC 3.6.5.5) ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2015-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 283643-9
    ISSN 1099-0844 ; 0263-6484
    ISSN (online) 1099-0844
    ISSN 0263-6484
    DOI 10.1002/cbf.3131
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Buch ; Konferenzbeitrag: Composites for the real world

    Beckwith, Scott W / Green, John E / Strong, A. Brent

    29th International SAMPE Technical Conference, Disney's Coronado Springs Resort, Orlando, Florida, October 28 - November 1, 1997

    (International SAMPE Technical Conference ; v. 29)

    1997  

    Körperschaft Society for the Advancement of Material and Process Engineering
    Veranstaltung/Kongress International SAMPE Technical Conference (29, 1997.10.28-11.01, OrlandoFla.)
    Verfasserangabe ed. by John E. Green
    Serientitel International SAMPE Technical Conference ; v. 29
    Sprache Englisch
    Umfang XVII, 823 S, Ill, 24 cm
    Verlag Society for the Advancement of Material and Process Engineering
    Erscheinungsort Covina, Calif
    Dokumenttyp Buch ; Konferenzbeitrag
    Anmerkung Includes bibliographical references and indexes
    ISBN 0938994786 ; 9780938994787
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang