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  1. Book: German gas appliance industry

    Gregg, R. J

    (B.I.O.S. final report ; 1591)

    1947  

    Author's details reported by R. J. Gregg
    Series title B.I.O.S. final report ; 1591
    Language English
    Size 21 S
    Publisher British Intelligence Objectives Sub-Committee
    Publishing place London
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article: P2X7-related modulation of pathological nociception in rats.

    McGaraughty, S / Chu, K L / Namovic, M T / Donnelly-Roberts, D L / Harris, R R / Zhang, X-F / Shieh, C-C / Wismer, C T / Zhu, C Z / Gauvin, D M / Fabiyi, A C / Honore, P / Gregg, R J / Kort, M E / Nelson, D W / Carroll, W A / Marsh, K / Faltynek, C R / Jarvis, M F

    Neuroscience

    2007  Volume 146, Issue 4, Page(s) 1817–1828

    Abstract: Growing evidence supports a role for the immune system in the induction and maintenance of chronic pain. ATP is a key neurotransmitter in this process. Recent studies demonstrate that the glial ATP receptor, P2X7, contributes to the modulation of ... ...

    Abstract Growing evidence supports a role for the immune system in the induction and maintenance of chronic pain. ATP is a key neurotransmitter in this process. Recent studies demonstrate that the glial ATP receptor, P2X7, contributes to the modulation of pathological pain. To further delineate the endogenous mechanisms that are involved in P2X7-related antinociception, we utilized a selective P2X7 receptor antagonist, A-438079, in a series of in vivo and in vitro experiments. Injection of A-438079 (10-300 micromol/kg, i.p.) was anti-allodynic in three different rat models of neuropathic pain and it attenuated formalin-induced nocifensive behaviors. Using in vivo electrophysiology, A-438079 (80 micromol/kg, i.v.) reduced noxious and innocuous evoked activity of different classes of spinal neurons (low threshold, nociceptive specific, wide dynamic range) in neuropathic rats. The effects of A-438079 on evoked firing were diminished or absent in sham rats. Spontaneous activity of all classes of spinal neurons was also significantly reduced by A-438079 in neuropathic but not sham rats. In vitro, A-438079 (1 microM) blocked agonist-induced (2,3-O-(4-benzoylbenzoyl)-ATP, 30 microM) current in non-neuronal cells taken from the vicinity of the dorsal root ganglia. Furthermore, A-438079 dose-dependently (0.3-3 microM) decreased the quantity of the cytokine, interleukin-1beta, released from peripheral macrophages. Thus, ATP, acting through the P2X7 receptor, exerts a wide-ranging influence on spinal neuronal activity following a chronic injury. Antagonism of the P2X7 receptor can in turn modulate central sensitization and produce antinociception in animal models of pathological pain. These effects are likely mediated through immuno-neural interactions that affect the release of endogenous cytokines.
    MeSH term(s) Action Potentials/drug effects ; Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/pharmacology ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Astrocytoma ; Behavior, Animal/drug effects ; Cell Line, Tumor ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Ganglia, Spinal ; Humans ; Interleukin-1beta/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Neurons ; Pain Measurement/methods ; Purinergic P2 Receptor Agonists ; Purinergic P2 Receptor Antagonists ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P2/physiology ; Receptors, Purinergic P2X7 ; Sciatica/drug therapy ; Sciatica/metabolism ; Sciatica/physiopathology ; Tetrazoles/pharmacology ; Tetrazoles/therapeutic use ; Time Factors
    Chemical Substances 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine ; Analgesics ; Interleukin-1beta ; P2RX7 protein, human ; P2rx7 protein, mouse ; P2rx7 protein, rat ; Purinergic P2 Receptor Agonists ; Purinergic P2 Receptor Antagonists ; Pyridines ; Receptors, Purinergic P2 ; Receptors, Purinergic P2X7 ; Tetrazoles ; 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate (4P5DXU1F8Q) ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2007-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2007.03.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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