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  1. Artikel ; Online: Mucosal cytokine profiles in paediatric eosinophilic oesophagitis: a case-control study.

    Romano, Claudio / Chiaro, Andrea / Lucarelli, Sandra / Santarelli, Cinzia / Cucchiara, Salvatore / Guadagnini, Tiziana / Miele, Erasmo / Di Nardo, Giovanni

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2014  Band 46, Heft 7, Seite(n) 590–595

    Abstract: Background: Eosinophilic oesophagitis is an inflammatory condition characterized by a dense eosinophilic infiltrate. The migration of eosinophils into the oesophagus is influenced by cytokines such as IL-5, IL-13 and eotaxin-3. The aim of this study was ...

    Abstract Background: Eosinophilic oesophagitis is an inflammatory condition characterized by a dense eosinophilic infiltrate. The migration of eosinophils into the oesophagus is influenced by cytokines such as IL-5, IL-13 and eotaxin-3. The aim of this study was to evaluate changes in the cytokine expression profiles (IL-5, IL-13 and eotaxin-3/CCL26) in children after topical steroid treatment.
    Methods: a prospective case-control study was performed in 23 paediatric patients (age 5-16 years) with a histological diagnosis of eosinophilic oesophagitis. Histological evaluation and cytokine levels assay (IL-5, IL-13 and eotaxin-3/CCL26) in the proximal and distal oesophagus were performed before, and after 8 weeks of topical budesonide. Data were compared with a matched healthy control group.
    Results: quantitative expression levels of IL-5, IL-13 and eotaxin-3 were significantly higher in the eosinophilic oesophagitis group both compared to healthy subjects (p<0.0001). A significant reduction of the eosinophil infiltrate as well as of IL-5, IL-13 and eotaxin-3 mucosal profiles was observed after steroid treatment both at the proximal and distal oesophagus (p<0.0001).
    Conclusions: IL-5, IL-13 and eotaxin-3/CCL26 are significantly over-expressed in the oesophageal epithelium of children with eosinophilic oesophagitis. Topical steroid treatment (inhaled and swallowed budesonide) can induce clinical response with partial mucosal remission.
    Mesh-Begriff(e) Administration, Topical ; Adolescent ; Anti-Inflammatory Agents/administration & dosage ; Budesonide/administration & dosage ; Case-Control Studies ; Chemokine CCL26 ; Chemokines, CC/metabolism ; Child ; Cytokines/metabolism ; Eosinophilic Esophagitis/drug therapy ; Eosinophilic Esophagitis/metabolism ; Eosinophilic Esophagitis/pathology ; Esophagus/metabolism ; Female ; Humans ; Interleukin-13/metabolism ; Interleukin-5/metabolism ; Male ; Mucous Membrane/metabolism ; Prospective Studies
    Chemische Substanzen Anti-Inflammatory Agents ; CCL26 protein, human ; Chemokine CCL26 ; Chemokines, CC ; Cytokines ; Interleukin-13 ; Interleukin-5 ; Budesonide (51333-22-3)
    Sprache Englisch
    Erscheinungsdatum 2014-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2014.03.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  2. Artikel ; Online: Transition of gastroenterological patients from paediatric to adult care: A position statement by the Italian Societies of Gastroenterology.

    Elli, Luca / Maieron, Roberto / Martelossi, Stefano / Guariso, Graziella / Buscarini, Elisabetta / Conte, Dario / di Giulio, Emilio / Staiano, Annamaria / Barp, Jacopo / Bassotti, Gabrio / Bianco, Maria Antonia / Buri, Luigi / Carrara, Maurizio / Ghidini, Benedetta / Giannini, Olivia / Knafelz, Daniela / Miele, Erasmo / Peralta, Sergio / Riccio, Elisabetta /
    Tomba, Carolina / Zilli, Maurizio / Guadagnini, Tiziana

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2015  Band 47, Heft 9, Seite(n) 734–740

    Abstract: In 2013, four Italian Gastroenterological Societies (the Italian Society of Paediatric Gastroenterology, Hepatology and Nutrition, the Italian Society of Hospital Gastroenterologists and Endoscopists, the Italian Society of Endoscopy, and the Italian ... ...

    Abstract In 2013, four Italian Gastroenterological Societies (the Italian Society of Paediatric Gastroenterology, Hepatology and Nutrition, the Italian Society of Hospital Gastroenterologists and Endoscopists, the Italian Society of Endoscopy, and the Italian Society of Gastroenterology) formed a joint panel of experts with the aim of preparing an official statement on transition medicine in Gastroenterology. The transition of adolescents from paediatric to adult care is a crucial moment in managing chronic diseases such as celiac disease, inflammatory bowel disease, liver disease and liver transplantation. Improved medical treatment and availability of new drugs and surgical techniques have improved the prognosis of many paediatric disorders, prolonging survival, thus making the transition to adulthood possible and necessary. An inappropriate transition or the incomplete transmission of data from the paediatrician to the adult Gastroenterologist can dramatically decrease compliance to treatment and prognosis of a young patient, particularly in the case of severe disorders. For these reasons, the Italian gastroenterological societies decided to develop an official shared transition protocol. The resulting document discusses the factors influencing the transition process and highlights the main points to accomplish to optimize compliance and prognosis of gastroenterological patients during the difficult transition from childhood to adolescence and adulthood.
    Mesh-Begriff(e) Celiac Disease/therapy ; Gastroenterology ; Humans ; Inflammatory Bowel Diseases/therapy ; Liver Diseases/therapy ; Pediatrics ; Physicians ; Practice Guidelines as Topic ; Societies, Medical ; Transition to Adult Care/legislation & jurisprudence
    Sprache Englisch
    Erscheinungsdatum 2015-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2015.04.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1134: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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