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  1. Artikel ; Online: Thermoring basis for the TRPV3 bio-thermometer

    Guangyu Wang

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 14

    Abstract: Abstract The thermosensitive transient receptor potential (TRP) channels are well-known as bio-thermometers with specific temperature thresholds and sensitivity. However, their precise structural origins are still mysterious. Here, graph theory was used ... ...

    Abstract Abstract The thermosensitive transient receptor potential (TRP) channels are well-known as bio-thermometers with specific temperature thresholds and sensitivity. However, their precise structural origins are still mysterious. Here, graph theory was used to test how the temperature-dependent non-covalent interactions as identified in the 3D structures of thermo-gated TRPV3 could form a systematic fluidic grid-like mesh network with the constrained thermo-rings from the biggest grids to the smallest ones as necessary structural motifs for the variable temperature thresholds and sensitivity. The results showed that the heat-evoked melting of the biggest grids may control the specific temperature thresholds to initiate channel gating while the smaller grids may be required to secure heat efficacy. Together, all the grids along the lipid-dependent minimal gating pathway may be necessary to change with molar heat capacity for the specific temperature sensitivity. Therefore, this graph theory-based grid thermodynamic model may provide an extensive structural basis for the thermo-gated TRP channels.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 541
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Lipid-dependent sequential allosteric activation of heat-sensing TRPV1 channels by anchor-stereoselective “hot” vanilloid compounds and analogs

    Guangyu Wang

    Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101109- (2021)

    2021  

    Abstract: Both a silent resident phosphatidylinositol lipid and a “hot” vanilloid agonist capsaicin or resiniferatoxin have been shown to share the same inter-subunit binding pocket between a voltage sensor like domain and a pore domain in TRPV1. However, how the ... ...

    Abstract Both a silent resident phosphatidylinositol lipid and a “hot” vanilloid agonist capsaicin or resiniferatoxin have been shown to share the same inter-subunit binding pocket between a voltage sensor like domain and a pore domain in TRPV1. However, how the vanilloid competes off the resident lipid for allosteric TRPV1 activation is unknown. Here, the in silico research suggested that anchor-stereoselective sequential cooperativity between an initial recessive transient silent weak ligand binding site and a subsequent dominant steady-state strong ligand binding site in the vanilloid pocket may facilitate the lipid release for allosteric activation of TRPV1 by vanilloids or analogs upon non-covalent interactions. Thus, the resident lipid may play a critical role in allosteric activation of TRPV1 by vanilloid compounds and analogs.
    Schlagwörter Sequential cooperativity ; Active site stereoselectivity ; Dominant steady-state ligand binding ; Recessive transient ligand binding ; Lipid-ligand interaction ; Hydrogen bonding network ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Design of a Semantic Understanding System for Optical Staff Symbols

    Fengbin Lou / Yaling Lu / Guangyu Wang

    Applied Sciences, Vol 13, Iss 23, p

    2023  Band 12627

    Abstract: Symbolic semantic understanding of staff images is an important technological support to achieve “intelligent score flipping”. Due to the complex composition of staff symbols and the strong semantic correlation between symbol spaces, it is difficult to ... ...

    Abstract Symbolic semantic understanding of staff images is an important technological support to achieve “intelligent score flipping”. Due to the complex composition of staff symbols and the strong semantic correlation between symbol spaces, it is difficult to understand the pitch and duration of each note when the staff is performed. In this paper, we design a semantic understanding system for optical staff symbols. The system uses the YOLOv5 to implement the optical staff’s low-level semantic understanding stage, which understands the pitch and duration in natural scales and other symbols that affect the pitch and duration. The proposed note encoding reconstruction algorithm is used to implement the high-level semantic understanding stage. Such an algorithm understands the logical, spatial, and temporal relationships between natural scales and other symbols based on music theory and outputs digital codes for the pitch and duration of the main notes during performances. The model is trained with a self-constructed SUSN dataset. Experimental results with YOLOv5 show that the precision is 0.989 and that the recall is 0.972. The system’s error rate is 0.031, and the omission rate is 0.021. The paper concludes by analyzing the causes of semantic understanding errors and offers recommendations for further research. The results of this paper provide a method for multimodal music artificial intelligence applications such as notation recognition through listening, intelligent score flipping, and automatic performance.
    Schlagwörter semantic understanding ; neural networks ; optical music recognition ; YOLOv5 ; digital code ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 780
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: The effect of node features on GCN-based brain network classification

    Guangyu Wang / Limei Zhang / Lishan Qiao

    PeerJ, Vol 11, p e

    an empirical study

    2023  Band 14835

    Abstract: Brain functional network (BFN) analysis has become a popular technique for identifying neurological/mental diseases. Due to the fact that BFN is a graph, a graph convolutional network (GCN) can be naturally used in the classification of BFN. Different ... ...

    Abstract Brain functional network (BFN) analysis has become a popular technique for identifying neurological/mental diseases. Due to the fact that BFN is a graph, a graph convolutional network (GCN) can be naturally used in the classification of BFN. Different from traditional methods that directly use the adjacency matrices of BFNs to train a classifier, GCN requires an additional input-node features. To our best knowledge, however, there is no systematic study to analyze their influence on the performance of GCN-based brain disorder classification. Therefore, in this study, we conduct an empirical study on various node feature measures, including (1) original fMRI signals, (2) one-hot encoding, (3) node statistics, (4) node correlation, and (5) their combination. Experimental results on two benchmark databases show that different node feature inputs to GCN significantly affect the brain disease classification performance, and node correlation usually contributes higher accuracy compared to original signals and manually extracted statistical features.
    Schlagwörter Graph convolutional network ; Node features ; Empirical study ; Mild cognitive impairment ; Autism spectrum disorder ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Fire regime and management in Canada's protected areas

    Weiwei Wang / Wanli Wu / Futao Guo / Guangyu Wang

    International Journal of Geoheritage and Parks, Vol 10, Iss 2, Pp 240-

    2022  Band 251

    Abstract: Wildland fires are a vital ecological process in Canada's protected areas (PAs), resulting in both ecological benefits and detrimental disturbances. In the face of rapid global changes, maximizing fire's ecological benefits while minimizing its negative ... ...

    Abstract Wildland fires are a vital ecological process in Canada's protected areas (PAs), resulting in both ecological benefits and detrimental disturbances. In the face of rapid global changes, maximizing fire's ecological benefits while minimizing its negative impacts is particularly difficult but essential for PA fire management. To facilitate fire management in Canada's PAs, we conducted a comprehensive review of fire regimes and management strategies in PAs using several scholarly sources and national databases. We found that a high proportion of protected areas are in the remote boreal forest region or the Montane Cordillera. Fire regimes varied from the high-intensity fires in the boreal forest region to the more complex mixed-severity fires in the Montane Cordillera ecozone. Numerous fire tools and science-based management plans have been developed to address the varied and complex fire regimes. However, many challenges are still presented under longer fire seasons with increasingly severe burning across the country. To cope with these challenges, we proposed a protection-conservation integrated fire management framework. It is expected to improve the capability of the existing tools in guiding both fire protection and ecological fire use in Canada's PAs.
    Schlagwörter fire regime ; fire management ; fire model ; prescribed fire ; protected areas ; Environmental sciences ; GE1-350 ; Geography (General) ; G1-922
    Thema/Rubrik (Code) 690
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag KeAi Communications Co., Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Digital Economy, R&D Investment, and Regional Green Innovation—Analysis Based on Provincial Panel Data in China

    Debao Dai / Yaodong Fan / Guangyu Wang / Jiaping Xie

    Sustainability, Vol 14, Iss 6508, p

    2022  Band 6508

    Abstract: The digital economy plays an important role in promoting regional green innovation. Based on the panel data of 30 provincial administrative regions in mainland China (except Tibet) from 2011 to 2018, this paper constructs a comprehensive development ... ...

    Abstract The digital economy plays an important role in promoting regional green innovation. Based on the panel data of 30 provincial administrative regions in mainland China (except Tibet) from 2011 to 2018, this paper constructs a comprehensive development index of the digital economy and explores the potential path of the digital economy affecting regional green innovation through factor analysis and regression analysis. The results show the following: Firstly, the digital economy can effectively promote regional green innovation capability. The causal relationship is mainly realized through scientific research funds and human resources. Secondly, in terms of regional heterogeneity, the role of the digital economy in promoting green innovation and R&D investment in eastern China is stronger than that in central and western China. Thirdly, further analysis showed that the digital economy has a significant nonlinear influence on regional green innovation capability. This feature is mainly reflected in the influence of R&D personnel on regional green innovation. Therefore, the rational allocation of R&D resources is conducive to the development of regional green innovation. Finally, it is suggested to improve the two mechanisms of R&D funds and personnel investment to actuate regional green innovation development.
    Schlagwörter digital economy ; R&D funds ; R&D personnel ; green innovation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 650 ; 339
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Editorial

    Hui Zhang / Guangyu Wang / Wenxing Long

    Frontiers in Ecology and Evolution, Vol

    Trait-Based Plant Community Assembly, Ecological Restoration, and the Biocontrol of Invasive Exotic Plant Species

    2022  Band 10

    Schlagwörter ecological restoration ; functional trait ; community assembly ; ecosystem functioning ; biocontrol ; trait-based restoration ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Synthesis and Insecticidal Activity of Fire Ant Venom Alkaloid-Based 2-Methyl-6-alkyl-Δ 1,6 -piperideines

    Xiaoqing Wu / Guangyu Wang / Guangxin Xu / Li Chen

    Molecules, Vol 27, Iss 1107, p

    2022  Band 1107

    Abstract: 2,6-dialkylpiperideines found in the venom of Solenopsis (Hymenoptera, Formicidae) fire ants are a range of compounds possessing various biological activities. A series of racemic 2-methyl-6-alkyl-Δ 1,6 -piperideines were synthesized for chemical ... ...

    Abstract 2,6-dialkylpiperideines found in the venom of Solenopsis (Hymenoptera, Formicidae) fire ants are a range of compounds possessing various biological activities. A series of racemic 2-methyl-6-alkyl-Δ 1,6 -piperideines were synthesized for chemical confirmation of the natural products found in fire ant venom, and the evaluation of their biological activity. Synthetic Δ 1,6 -piperideines and the natural compounds in the cis -alkaloid fraction of Solenopsis invicta had identical mass spectra and retention times. Their insecticidal activities against the third-instar larvae of cotton bollworm ( Helicoverpa armigera ) were evaluated by using injection and topical application methods. All three compounds exhibited no lethal effect at concentrations of 0.05–0.4 mol/L by topical treatment, but moderate lethal effect at 0.4 mol/L through injection treatment. Compound 6a showed significantly higher activity than the natural insecticide nicotine. The differences in activity among compounds 6b , 6c and nicotine were not significant. The elongation of the carbon chain at the 6-position of the piperideine ring appears to decrease insecticidal activity.
    Schlagwörter piperideine ; venom ; Solenopsis invicta ; biological activity ; contact toxicity ; injection toxicity ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Examining the links between livelihood sustainability and environmental protection in the anti-poverty relocation and settlement program areas

    Manman Guo / Cong Li / Guangyu Wang / John L. Innes

    Frontiers in Environmental Science, Vol

    An empirical analysis of Shaanxi, China

    2022  Band 10

    Abstract: Consistent with the 2030 agenda for sustainable development, China has initiated a large-scale anti-poverty relocation and settlement program (the ARSP), aiming to restore ecosystems and lift impoverished populations out of the poverty trap and into ... ...

    Abstract Consistent with the 2030 agenda for sustainable development, China has initiated a large-scale anti-poverty relocation and settlement program (the ARSP), aiming to restore ecosystems and lift impoverished populations out of the poverty trap and into sustainable livelihoods. Unlike previous studies that focus on the population issues of the ARSP, we examine the links between livelihood sustainability and environmental protection (“livelihoods–environment”) in the ARSP areas. We found that the links are generally weak, with low levels of both livelihood sustainability and environmental protection. The disorder category is the most common in both the overall and the regional samples, with the mild and borderline disorder categories being the most common subcategories. The results varied regionally, and indicated that environmental problems can be more prominent in regions with fragile environments. Household-level distribution shows significant differences in the strengths of the links among different demographic groups, and regression results show that higher levels of average education, loan amount, and asset holdings, as well as lower proportions of the elderly and non-agricultural activities were associated with stronger links. These household factors influenced the links through different mechanisms.
    Schlagwörter livelihood sustainability ; environmental protection ; anti-poverty ; resettlement ; China ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Study on the Impact of Spatial Resolution on Fractional Vegetation Cover Extraction with Single-Scene and Time-Series Remote Sensing Data

    Yanfang Wang / Lu Tan / Guangyu Wang / Xinyu Sun / Yannan Xu

    Remote Sensing, Vol 14, Iss 4165, p

    2022  Band 4165

    Abstract: The spatial resolution of remote sensing images directly affects the accuracy, efficiency, and computational cost of extracting the fractional vegetation cover (FVC). Taking the Liyang woodland region, Jiangsu Province, as the study area, FVCs with ... ...

    Abstract The spatial resolution of remote sensing images directly affects the accuracy, efficiency, and computational cost of extracting the fractional vegetation cover (FVC). Taking the Liyang woodland region, Jiangsu Province, as the study area, FVCs with varying spatial resolutions were extracted separately from Sentinel-2, Landsat-8, MOD13Q1, and MOD13A1. The variations in FVCs extracted from remote sensing images with varying spatial resolutions were analyzed at one specific time and time series within a year. The results show that (i) the overall mean FVC values of the four spatial resolution images did not differ substantially; however, FVCs with varying spatial resolutions present with a regular pattern of overestimation or underestimation at different vegetation levels. (ii) Taking the 10 m spatial resolution FVC as the reference, the accuracy values of FVC extraction at 30 m, 250 m, and 500 m resolutions were 91.0%, 76.3%, and 76.7%, respectively. The differences in the spatial distribution of FVCs are the most obvious at water–land interfaces and at the edge of each woodland patch. (iii) The highest accuracy of time-series FVC extraction from lower-resolution images is in the range of 0.6~0.7 for FVC. The degree of variation in FVC of time series varying spatial resolutions depends on the season and vegetation cover conditions. In summary, there are considerable differences in the need to monitor high-resolution images depending on the FVC level of the land surface. This study provides a reference for selection and accuracy research of remote sensing images for FVC extraction.
    Schlagwörter fractional vegetation cover ; Sentinel-2 ; Landsat-8 ; MODIS ; Science ; Q
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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