Artikel ; Online: Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.
2022 Band 130, Heft 10, Seite(n) 1510–1530
Abstract: Background: Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of ... ...
| Abstract | Background: Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies. Methods: We used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity. Results: In addition to macrophages, we found a high proportion of αβ T cells in the coronary plaques. Most of these T cells lack high expression of Conclusions: Taken together, these findings demonstrate that plaque T cells are clonally expanded potentially by antigen engagement, are potentially reactive to self-epitopes, and may interact with smooth muscle cells and macrophages in the plaque microenvironment. |
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| Mesh-Begriff(e) | Antigens ; Clone Cells/immunology ; Coronary Artery Disease/immunology ; Endothelial Cells ; Epitopes ; HLA-DR alpha-Chains ; Humans ; Lymphocyte Activation ; Plaque, Atherosclerotic/immunology ; T-Lymphocytes/immunology |
| Chemische Substanzen | Antigens ; Epitopes ; HLA-DR alpha-Chains |
| Sprache | Englisch |
| Erscheinungsdatum | 2022-04-18 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
| ZDB-ID | 80100-8 |
| ISSN | 1524-4571 ; 0009-7330 ; 0931-6876 |
| ISSN (online) | 1524-4571 |
| ISSN | 0009-7330 ; 0931-6876 |
| DOI | 10.1161/CIRCRESAHA.121.320090 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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