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  1. Artikel: Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?

    Gupta, Suchi Smita / Singh, Krishna P / Gupta, Shailendra / Dusinska, Maria / Rahman, Qamar

    Nanomaterials (Basel, Switzerland)

    2022  Band 12, Heft 10

    Abstract: During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 tons/year. Besides several ... ...

    Abstract During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 tons/year. Besides several commercial benefits of CNTs, the fiber-like structures and their bio-persistency in lung tissues raise serious concerns about the possible adverse human health effects resembling those of asbestos fibers. In this review, we present a comparative analysis between CNTs and asbestos fibers using the following four parameters: (1) fibrous needle-like shape, (2) bio-persistent nature, (3) high surface to volume ratio and (4) capacity to adsorb toxicants/pollutants on the surface. We also compare mechanisms underlying the toxicity caused by certain diameters and lengths of CNTs and asbestos fibers using downstream pathways associated with altered gene expression data from both asbestos and CNT exposure. Our results suggest that indeed certain types of CNTs are emulating asbestos fiber as far as associated toxicity is concerned.
    Sprache Englisch
    Erscheinungsdatum 2022-05-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12101708
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The Atlas of Inflammation Resolution (AIR).

    Serhan, Charles N / Gupta, Shailendra K / Perretti, Mauro / Godson, Catherine / Brennan, Eoin / Li, Yongsheng / Soehnlein, Oliver / Shimizu, Takao / Werz, Oliver / Chiurchiù, Valerio / Azzi, Angelo / Dubourdeau, Marc / Gupta, Suchi Smita / Schopohl, Patrick / Hoch, Matti / Gjorgevikj, Dragana / Khan, Faiz M / Brauer, David / Tripathi, Anurag /
    Cesnulevicius, Konstantin / Lescheid, David / Schultz, Myron / Särndahl, Eva / Repsilber, Dirk / Kruse, Robert / Sala, Angelo / Haeggström, Jesper Z / Levy, Bruce D / Filep, János G / Wolkenhauer, Olaf

    Molecular aspects of medicine

    2020  Band 74, Seite(n) 100894

    Abstract: Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue damage. Ideally, the response should be localized, self-limited, and returning to homeostasis. If not resolved, acute inflammation can result in ... ...

    Abstract Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue damage. Ideally, the response should be localized, self-limited, and returning to homeostasis. If not resolved, acute inflammation can result in organ pathologies leading to chronic inflammatory phenotypes. Acute inflammation and inflammation resolution are complex coordinated processes, involving a number of cell types, interacting in space and time. The biomolecular complexity and the fact that several biomedical fields are involved, make a multi- and interdisciplinary approach necessary. The Atlas of Inflammation Resolution (AIR) is a web-based resource capturing an essential part of the state-of-the-art in acute inflammation and inflammation resolution research. The AIR provides an interface for users to search thousands of interactions, arranged in inter-connected multi-layers of process diagrams, covering a wide range of clinically relevant phenotypes. By mapping experimental data onto the AIR, it can be used to elucidate drug action as well as molecular mechanisms underlying different disease phenotypes. For the visualization and exploration of information, the AIR uses the Minerva platform, which is a well-established tool for the presentation of disease maps. The molecular details of the AIR are encoded using international standards. The AIR was created as a freely accessible resource, supporting research and education in the fields of acute inflammation and inflammation resolution. The AIR connects research communities, facilitates clinical decision making, and supports research scientists in the formulation and validation of hypotheses. The AIR is accessible through https://air.bio.informatik.uni-rostock.de.
    Mesh-Begriff(e) Homeostasis ; Humans ; Inflammation ; Inflammation Mediators
    Chemische Substanzen Inflammation Mediators
    Sprache Englisch
    Erscheinungsdatum 2020-09-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2020.100894
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: WITHDRAWN: The Atlas of Inflammation Resolution (AIR).

    Serhan, Charles N / Gupta, Shailendra K / Perretti, Mauro / Godson, Catherine / Brennan, Eoin / Li, Yongsheng / Soehnlein, Oliver / Shimizu, Takao / Werz, Oliver / Chiurchiù, Valerio / Azzi, Angelo / Dubourdeau, Marc / Gupta, Suchi Smita / Schopohl, Patrick / Hoch, Matti / Gjorgevikj, Dragana / Khan, Faiz M / Brauer, David / Tripathi, Anurag /
    Cesnulevicius, Konstantin / Lescheid, David / Schultz, Myron / Särndahl, Eva / Repsilber, Dirk / Kruse, Robert / Sala, Angelo / Haeggström, Jesper Z / Levy, Bruce D / Filep, János G / Wolkenhauer, Olaf

    Molecular aspects of medicine

    2020  , Seite(n) 100893

    Sprache Englisch
    Erscheinungsdatum 2020-08-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2020.100893
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1189: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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