Artikel ; Online: Exercise and inactivity as modifiers of β cell function and type 2 diabetes risk.
Journal of applied physiology (Bethesda, Md. : 1985)
2023 Band 134, Heft 4, Seite(n) 823–839
Abstract: Exercise and regular physical activity are beneficial for the prevention and management of metabolic diseases such as obesity and type 2 diabetes, whereas exercise cessation, defined as deconditioning from regular exercise or physical activity that has ... ...
Abstract | Exercise and regular physical activity are beneficial for the prevention and management of metabolic diseases such as obesity and type 2 diabetes, whereas exercise cessation, defined as deconditioning from regular exercise or physical activity that has lasted for a period of months to years, can lead to metabolic derangements that drive disease. Adaptations to the insulin-secreting pancreatic β-cells are an important benefit of exercise, whereas less is known about how exercise cessation affects these cells. Our aim is to review the impact that exercise and exercise cessation have on β-cell function, with a focus on the evidence from studies examining glucose-stimulated insulin secretion (GSIS) using gold-standard techniques. Potential mechanisms by which the β-cell adapts to exercise, including exerkine and incretin signaling, autonomic nervous system signaling, and changes in insulin clearance, will also be explored. We will highlight areas for future research. |
---|---|
Mesh-Begriff(e) | Humans ; Diabetes Mellitus, Type 2/metabolism ; Insulin/metabolism ; Glucose/metabolism ; Insulin-Secreting Cells/metabolism ; Exercise/physiology |
Chemische Substanzen | Insulin ; Glucose (IY9XDZ35W2) |
Sprache | Englisch |
Erscheinungsdatum | 2023-02-09 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 219139-8 |
ISSN | 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587 |
ISSN (online) | 1522-1601 |
ISSN | 0021-8987 ; 0161-7567 ; 8750-7587 |
DOI | 10.1152/japplphysiol.00472.2022 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Uc I Zs.249: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.