Article ; Online: The sex-related discrepancy in laboratory parameters of severe COVID-19 patients with diabetes: A retrospective cohort study.
2021 Volume 15, Issue 4, Page(s) 713–718
Abstract: Aim: This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes.: Methods: For 118 diabetic patients, laboratory measurements and clinical outcomes were ... ...
Abstract | Aim: This study aimed at providing evidence to consider sex differences in interpretations of laboratory parameters of severe COVID-19 patients with diabetes. Methods: For 118 diabetic patients, laboratory measurements and clinical outcomes were compared between males and females. This study also compared inflammatory ratios obtained from combinations of six inflammatory markers between the two groups. The risk factors for mortality were identified through logistic regression. Results: Males were 54 (45.8%) and females were 64 (54.2%). Males showed a significant increase in ALT (P = 0.003), CRP (P = 0.03), mean platelet volume (MPV)-to-lymphocyte ratio (P = 0.001), and C-reactive protein-to-albumin ratio (P = 0.044), whereas females had a significant increase in lymphocytes (P < 0.005) and MPV (P = 0.01). In all participants, multivariate analysis illustrated that older age, male sex, increased serum total bilirubin, and decreased PO Conclusion: In severe COVID-19 patients with diabetes, there were significant sex differences in many laboratory characteristics with a higher risk of mortality among males. |
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MeSH term(s) | Age Factors ; Aged ; Alanine Transaminase/blood ; Bilirubin/blood ; Biomarkers/blood ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/mortality ; Female ; Health Status Disparities ; Humans ; Lymphocyte Count ; Lymphocytes/metabolism ; Male ; Mean Platelet Volume ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Sex Factors |
Chemical Substances | Biomarkers ; C-Reactive Protein (9007-41-4) ; Alanine Transaminase (EC 2.6.1.2) ; Bilirubin (RFM9X3LJ49) |
Language | English |
Publishing date | 2021-05-12 |
Publishing country | England |
Document type | Comparative Study ; Journal Article ; Observational Study |
ZDB-ID | 2273997-X |
ISSN | 1878-0210 ; 1751-9918 |
ISSN (online) | 1878-0210 |
ISSN | 1751-9918 |
DOI | 10.1016/j.pcd.2021.05.002 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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