Artikel ; Online: Diverging humoral and cellular immune responses due to Omicron-a national study from the Faroe Islands.
2023 Band 11, Heft 6, Seite(n) e0086523
Abstract: Importance: The immunity following infection and vaccination with the SARS-CoV-2 Omicron variant is poorly understood. We investigated immunity assessed with antibody and T-cell responses under different scenarios in vaccinated and unvaccinated ... ...
Abstract | Importance: The immunity following infection and vaccination with the SARS-CoV-2 Omicron variant is poorly understood. We investigated immunity assessed with antibody and T-cell responses under different scenarios in vaccinated and unvaccinated individuals with and without Omicron infection. We found that the humoral response was higher among vaccinated-naïve than unvaccinated convalescent. Unvaccinated with and without infection had comparable low humoral responses, whereas vaccinated with a second or third dose, independent of infection status, had increasingly higher levels. Only a minor fraction of unvaccinated individuals had detectable humoral responses following Omicron infection, while almost all had positive T-cell responses. In conclusion, primary Omicron infection mounts a low humoral immune response, enhanced by prior vaccination. Omicron infection induced a robust T-cell response in both unvaccinated and vaccinated, demonstrating that immune evasion of primary Omicron infection affects humoral immunity more than T-cell immunity. |
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Mesh-Begriff(e) | Humans ; Denmark ; Immune Evasion ; Immunity, Humoral ; Vaccination ; Immunity, Cellular ; Antibodies, Viral ; Antibodies, Neutralizing |
Chemische Substanzen | Antibodies, Viral ; Antibodies, Neutralizing |
Sprache | Englisch |
Erscheinungsdatum | 2023-11-01 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 2807133-5 |
ISSN | 2165-0497 ; 2165-0497 |
ISSN (online) | 2165-0497 |
ISSN | 2165-0497 |
DOI | 10.1128/spectrum.00865-23 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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