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  1. Buch ; Online ; E-Book: A transdiagnostic approach to develop organization, attention and learning skills

    Hansen, Laura K.

    the GOALS treatment manual for college students

    2023  

    Verfasserangabe Laura K. Hansen
    Schlagwörter Executive functions (Neuropsychology) ; Study skills
    Thema/Rubrik (Code) 616.8900835
    Sprache Englisch
    Umfang 1 online resource (151 pages)
    Verlag Routledge
    Erscheinungsort London, England ; New York, New York
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-319961-5 ; 1-003-19961-5 ; 1-000-62731-4 ; 1-03-205877-3 ; 978-1-00-319961-8 ; 978-1-003-19961-8 ; 978-1-000-62731-2 ; 978-1-03-205877-1
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Dissertation / Habilitation: Einfluss von verschiedenen Kontrollstrategien auf die oberflächenelektromyographische Aktivitätscharakteristik der Rumpfmuskulatur

    Hansen, Laura

    2018  

    Verfasserangabe vorgelegt von Laura Hansen
    Sprache Deutsch ; Englisch
    Umfang I, 72 Seiten, Illustrationen, Diagramme, 30 cm
    Erscheinungsort Jena
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Friedrich-Schiller-Universität Jena, 2018
    HBZ-ID HT019725199
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2018 E 730 bestellbar zur Ausleihe Magazin

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  3. Artikel ; Online: The Development of CDC25A-Derived Phosphoseryl Peptides That Bind 14-3-3ε with High Affinities.

    Kamayirese, Seraphine / Maity, Sibaprasad / Hansen, Laura A / Lovas, Sándor

    International journal of molecular sciences

    2024  Band 25, Heft 9

    Abstract: Overexpression of the 14-3-3ε protein is associated with suppression of apoptosis in cutaneous squamous cell carcinoma (cSCC). This antiapoptotic activity of 14-3-3ε is dependent on its binding to CDC25A; thus, inhibiting 14-3-3ε - CDC25A interaction is ... ...

    Abstract Overexpression of the 14-3-3ε protein is associated with suppression of apoptosis in cutaneous squamous cell carcinoma (cSCC). This antiapoptotic activity of 14-3-3ε is dependent on its binding to CDC25A; thus, inhibiting 14-3-3ε - CDC25A interaction is an attractive therapeutic approach to promote apoptosis in cSCC. In this regard, designing peptide inhibitors of 14-3-3ε - CDC25A interactions is of great interest. This work reports the rational design of peptide analogs of pS, a CDC25A-derived peptide that has been shown to inhibit 14-3-3ε-CDC25A interaction and promote apoptosis in cSCC with micromolar IC
    Mesh-Begriff(e) cdc25 Phosphatases/metabolism ; cdc25 Phosphatases/chemistry ; cdc25 Phosphatases/antagonists & inhibitors ; 14-3-3 Proteins/metabolism ; 14-3-3 Proteins/chemistry ; Protein Binding ; Molecular Dynamics Simulation ; Humans ; Peptides/chemistry ; Peptides/metabolism ; Amino Acid Sequence
    Chemische Substanzen cdc25 Phosphatases (EC 3.1.3.48) ; 14-3-3 Proteins ; Peptides ; CDC25A protein, human (EC 3.1.3.48)
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094918
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Optimization of Oxygen Delivery Within Hydrogels.

    Mavris, Sophia M / Hansen, Laura M

    Journal of biomechanical engineering

    2021  Band 143, Heft 10

    Abstract: The field of tissue engineering has been continuously evolving since its inception over three decades ago with numerous new advancements in biomaterials and cell sources and widening applications to most tissues in the body. Despite the substantial ... ...

    Abstract The field of tissue engineering has been continuously evolving since its inception over three decades ago with numerous new advancements in biomaterials and cell sources and widening applications to most tissues in the body. Despite the substantial promise and great opportunities for the advancement of current medical therapies and procedures, the field has yet to capture wide clinical translation due to some remaining challenges, including oxygen availability within constructs, both in vitro and in vivo. While this insufficiency of nutrients, specifically oxygen, is a limitation within the current frameworks of this field, the literature shows promise in new technological advances to efficiently provide adequate delivery of nutrients to cells. This review attempts to capture the most recent advances in the field of oxygen transport in hydrogel-based tissue engineering, including a comparison of current research as it pertains to the modeling, sensing, and optimization of oxygen within hydrogel constructs as well as new technological innovations to overcome traditional diffusion-based limitations. The application of these findings can further the advancement and development of better hydrogel-based tissue engineered constructs for future clinical translation and adoption.
    Mesh-Begriff(e) Hydrogels
    Chemische Substanzen Hydrogels
    Sprache Englisch
    Erscheinungsdatum 2021-05-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4051119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Optimizing Phosphopeptide Structures That Target 14-3-3ε in Cutaneous Squamous Cell Carcinoma.

    Kamayirese, Seraphine / Maity, Sibaprasad / Dieckman, Lynne M / Hansen, Laura A / Lovas, Sándor

    ACS omega

    2024  Band 9, Heft 2, Seite(n) 2719–2729

    Abstract: 14-3-3ε is involved in various types of malignancies by increasing cell proliferation, promoting cell invasion, or inhibiting apoptosis. In cutaneous squamous cell carcinoma (cSCC), 14-3-3ε is overexpressed and mislocalized from the nucleus to the ... ...

    Abstract 14-3-3ε is involved in various types of malignancies by increasing cell proliferation, promoting cell invasion, or inhibiting apoptosis. In cutaneous squamous cell carcinoma (cSCC), 14-3-3ε is overexpressed and mislocalized from the nucleus to the cytoplasm where it interacts with the cell division cycle 25 A (CDC25A) and suppresses apoptosis. Hence, inhibition of the 14-3-3ε-CDC25A interaction is an attractive target for promoting apoptosis in cSCC. In this work, we optimized the structure of our previously designed inhibitor of the 14-3-3ε-CDC25A interaction, pT, a phosphopeptide fragment corresponding to one of the two binding regions of CDC25A to 14-3-3ε. Starting from pT, we developed peptide analogs that bind 14-3-3ε with nanomolar affinities. Peptide analogs were designed by shortening the pT peptide and introducing modifications at position 510 of the pT(502-510) analog. Both molecular dynamics (MD) simulations and biophysical methods were used to determine peptide binding to 14-3-3ε. Shortening the pT peptide from 14 to 9 amino acid residues resulted in a peptide (pT(502-510)) that binds 14-3-3ε with a
    Sprache Englisch
    Erscheinungsdatum 2024-01-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07740
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Compressor Scheduling and Pressure Control for an Alternating Aeration Activated Sludge Process—A Simulation Study Validated on Plant Data

    Hansen, Laura Debel / Veng, Morten / Durdevic, Petar

    Water. 2021 Apr. 09, v. 13, no. 8

    2021  

    Abstract: Aiming at reducing their emissions, wastewater treatment plants (WWTP) seek to reduce their energy consumption, where a large amount is used for the aeration. The case plant, Grindsted WWTP uses an alternating aeration strategy, with a common air supply ... ...

    Abstract Aiming at reducing their emissions, wastewater treatment plants (WWTP) seek to reduce their energy consumption, where a large amount is used for the aeration. The case plant, Grindsted WWTP uses an alternating aeration strategy, with a common air supply system facilitating the process in four aeration tanks and thus making optimisation challenging. In this work, a nonlinear model of the air supply system is designed, in which multiple key parameters are estimated by data-driven optimization. Subsequently, a model-based control strategy for scheduling of compressors and desired airflow is proposed, to save energy without compromising the aeration performance. The strategy is based upon partly static- partly dynamic models of the compressors, describing their efficiency in terms of system head and volumetric airflow rate. The simulation study uses real plant data and shows great potential for improvement of energy efficiency, regardless of the aeration pattern in any of the four process tanks, and furthermore contributes to a reduction in compressor restarts per day. The proposed method is applicable to other WWTP with multiple compressors in the air supply system, as this study is conducted using first principle models validated on data from the daily operation.
    Schlagwörter aeration ; air ; air flow ; energy efficiency ; head ; nonlinear models ; wastewater treatment ; water
    Sprache Englisch
    Erscheinungsverlauf 2021-0409
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w13081037
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel: Mating and adult feeding behaviour influence pheromone production in female Asian longhorn beetle Anoplophora glabripennis (Coleoptera: Cerambycidae)

    Xu, Tian / Hansen, Laura / Teale, Stephen A.

    Agricultural and forest entomology. 2021 Aug., v. 23, no. 3

    2021  

    Abstract: The Asian longhorn beetle (ALB) Anoplophora glabripennis Motschulsky is a destructive invasive species worldwide. Female ALB produce a pheromone component, α‐longipinene, in the genitalia. However, the origin and factors, such as age, mating, adult ... ...

    Abstract The Asian longhorn beetle (ALB) Anoplophora glabripennis Motschulsky is a destructive invasive species worldwide. Female ALB produce a pheromone component, α‐longipinene, in the genitalia. However, the origin and factors, such as age, mating, adult feeding and host plant, influencing the production of this compound are unclear. Our results showed that virgin female ALB consistently produced α‐longipinene at various ages after feeding for several days post eclosion, but unfed adult females never produced this compound. Mating significantly reduced the amount of α‐longipinene in female genitalia. α‐Longipinene was the most dominant compound in the volatiles emitted by females, but not in those emitted by males or host twigs (Acer pensylvanicum L.). The proportion of α‐longipinene among the beetle‐released sesquiterpenes that were known to be male antennally active was significantly greater than that emitted by ALB damaged, mechanically damaged or control twigs. These results suggest that ALB females probably derive α‐longipinene or a precursor from hosts via adult feeding, and release it at a significantly different ratio from that found in host volatiles. The various ratios of α‐longipinene produced by beetles and host twigs may encode information pertaining to multiple purposes such as aggregation, mate and host location.
    Schlagwörter Acer pensylvanicum ; Anoplophora glabripennis ; adults ; eclosion ; entomology ; female genitalia ; females ; forests ; host plants ; invasive species ; males ; pheromones ; sesquiterpenoids
    Sprache Englisch
    Erscheinungsverlauf 2021-08
    Umfang p. 276-286.
    Erscheinungsort Blackwell Publishing Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1444210-3
    ISSN 1461-9563 ; 1461-9555
    ISSN (online) 1461-9563
    ISSN 1461-9555
    DOI 10.1111/afe.12430
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 7190: Hefte anzeigen

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  8. Artikel: Optimizing Phosphopeptide Structures That Target 14-3-3ε in Cutaneous Squamous Cell Carcinoma.

    Kamayirese, Seraphine / Maity, Sibaprasad / Dieckman, Lynne M / Hansen, Laura A / Lovas, Sándor

    bioRxiv : the preprint server for biology

    2023  

    Abstract: 14-3-3ε is involved in various types of malignancies by increasing cell proliferation, promoting cell invasion or inhibiting apoptosis. In cutaneous squamous cell carcinoma (cSCC), 14-3-3ε is over expressed and mislocalized from the nucleus to the ... ...

    Abstract 14-3-3ε is involved in various types of malignancies by increasing cell proliferation, promoting cell invasion or inhibiting apoptosis. In cutaneous squamous cell carcinoma (cSCC), 14-3-3ε is over expressed and mislocalized from the nucleus to the cytoplasm where it interacts with the cell division cycle 25 A (CDC25A) and suppresses apoptosis. Hence inhibition of the 14-3-3ε - CDC25A interaction is an attractive target for promoting apoptosis in cSCC. In this work, we optimized the structure of our previously designed inhibitor of 14-3-3ε - CDC25A interaction, pT, a phosphopeptide fragment corresponding to one of the two binding regions of CDC25A to 14-3-3ε. Starting from pT, we developed peptide analogs that bind 14-3-3ε with nanomolar affinities. Peptide analogs were designed by shortening the pT peptide, and introducing modifications at position 510 of the pT(502-510) analog. Both molecular dynamics (MD) simulations and biophysical methods were used to determine peptides binding to 14-3-3ε. Shortening the pT peptide from 14 to 9 amino acid residues resulted in a peptide (pT(502-510)) that binds 14-3-3ε with a K
    Sprache Englisch
    Erscheinungsdatum 2023-10-03
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.03.560749
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Membrane structure and internalization dynamics of human Flower isoforms hFWE3 and hFWE4 indicate a conserved endocytic role for hFWE4.

    Rudd, Justin C / Maity, Sibaprasad / Grunkemeyer, James A / Snyder, Joshua C / Lovas, Sándor / Hansen, Laura A

    The Journal of biological chemistry

    2023  Band 299, Heft 8, Seite(n) 104945

    Abstract: Human Flower (hFWE) isoforms hFWE1-4 are putative transmembrane (TM) proteins that reportedly mediate fitness comparisons during cell competition through extracellular display of their C-terminal tails. Isoform topology, subcellular localization, and ... ...

    Abstract Human Flower (hFWE) isoforms hFWE1-4 are putative transmembrane (TM) proteins that reportedly mediate fitness comparisons during cell competition through extracellular display of their C-terminal tails. Isoform topology, subcellular localization, and duration of plasma membrane presentation are essential to this function. However, disagreement persists regarding the structure of orthologous fly and mouse FWEs, and experimental evidence for hFWE isoform subcellular localization or membrane structure is lacking. Here, we used AlphaFold2 and subsequent molecular dynamics-based structural predictions to construct epitope-tagged hFWE3 and hFWE4, the most abundant human isoforms, for experimental determination of their structure and internalization dynamics. We demonstrate that hFWE3 resides in the membrane of the endoplasmic reticulum (ER), while hFWE4 partially colocalizes with Rab4-, Rab5-, and Rab11-positive vesicles as well as with the plasma membrane. An array of imaging techniques revealed that hFWE4 positions both N- and C-terminal tails and a loop between second and third TM segments within the cytosol, while small (4-12aa) loops between the first and second and the third and fourth TM segments are either exposed to the extracellular space or within the lumen of cytoplasmic vesicles. Similarly, we found hFWE3 positions both N- and C-terminal tails in the cytosol, while a short loop between TM domains extends into the ER lumen. Finally, we demonstrate that hFWE4 exists only transiently at the cell surface and is rapidly internalized in an AP-2- and dynamin-1-dependent manner. Collectively, these data are consistent with a conserved role for hFWE4 in endocytic processes.
    Mesh-Begriff(e) Humans ; Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Endocytosis ; Endoplasmic Reticulum/metabolism ; Membrane Proteins/metabolism ; Membrane Proteins/ultrastructure ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Isoforms/ultrastructure ; Cytoplasmic Vesicles/metabolism ; Cytoplasmic Vesicles/ultrastructure ; Molecular Dynamics Simulation ; Protein Structure, Tertiary ; Clathrin/metabolism ; HEK293 Cells ; Models, Molecular
    Chemische Substanzen Membrane Proteins ; Protein Isoforms ; Clathrin
    Sprache Englisch
    Erscheinungsdatum 2023-06-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.104945
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The effect of early follow-up after open cardiac surgery in a student clinic.

    Ilkjær, Christine / Hoffmann, Torben / Heiberg, Johan / Hansen, Laura Sommer / Hjortdal, Vibeke E

    Scandinavian cardiovascular journal : SCJ

    2023  Band 57, Heft 1, Seite(n) 2184861

    Abstract: ... ...

    Abstract Objectives
    Mesh-Begriff(e) Humans ; Risk Factors ; Follow-Up Studies ; Quality of Life ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Postoperative Complications/diagnosis ; Cardiac Surgical Procedures/adverse effects ; Students ; Patient Readmission
    Sprache Englisch
    Erscheinungsdatum 2023-03-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1379906-x
    ISSN 1651-2006 ; 1401-7431
    ISSN (online) 1651-2006
    ISSN 1401-7431
    DOI 10.1080/14017431.2023.2184861
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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