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  1. Artikel ; Online: Highly Efficient Ag 3 PO 4 /g-C 3 N 4 Z-Scheme Photocatalyst for its Enhanced Photocatalytic Performance in Degradation of Rhodamine B and Phenol

    Mingxi Zhang / Hanxiao Du / Juan Ji / Fengfeng Li / Y. C. Lin / Chenwei Qin / Ze Zhang / Yi Shen

    Molecules, Vol 26, Iss 2062, p

    2021  Band 2062

    Abstract: Ag 3 PO 4 /g-C 3 N 4 heterojunctions, with different g-C 3 N 4 dosages, were synthesized using an in situ deposition method, and the photocatalytic performance of g-C 3 N 4 /Ag 3 PO 4 heterojunctions was studied under simulated sunlight conditions. The ... ...

    Abstract Ag 3 PO 4 /g-C 3 N 4 heterojunctions, with different g-C 3 N 4 dosages, were synthesized using an in situ deposition method, and the photocatalytic performance of g-C 3 N 4 /Ag 3 PO 4 heterojunctions was studied under simulated sunlight conditions. The results revealed that Ag 3 PO 4 /g-C 3 N 4 exhibited excellent photocatalytic degradation activity for rhodamine B (Rh B) and phenol under the same light conditions. When the dosage of g-C 3 N 4 was 30%, the degradation rate of Rh B at 9 min and phenol at 30 min was found to be 99.4% and 97.3%, respectively. After five cycles of the degradation experiment for Rh B, g-C 3 N 4 /Ag 3 PO 4 still demonstrated stable photodegradation characteristics. The significant improvement in the photocatalytic activity and stability of g-C 3 N 4 /Ag 3 PO 4 was attributed to the rapid charge separation between g-C 3 N 4 and Ag 3 PO 4 during the Z-scheme charge transfer and recombination process.
    Schlagwörter Ag 3 PO 4 ; g-C 3 N 4 ; semiconductor photocatalyst ; Z-scheme mechanism ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Noninvasive prenatal prediction of fetal haplotype with Spearman rank correlation analysis model.

    Hanxiao, Du / Luming, Sun / Songchang, Chen / Jingmin, Yang / Yueping, Zhang / Shuo, Zhang / Hongyan, Chen / Ning, Jiang / Daru, Lu

    Molecular genetics & genomic medicine

    2022  Band 10, Heft 8, Seite(n) e1988

    Abstract: Background: Noninvasive prenatal testing (NIPT) has been widely used clinically to detect fetal chromosomal aneuploidy with high accuracy rates, gradually replacing traditional serological screening. However, the application of NIPT for monogenic ... ...

    Abstract Background: Noninvasive prenatal testing (NIPT) has been widely used clinically to detect fetal chromosomal aneuploidy with high accuracy rates, gradually replacing traditional serological screening. However, the application of NIPT for monogenic diseases is still in an immature stage of exploration. The detection of mutations in peripheral blood of pregnant women requires precise qualitative and quantitative techniques, which limits its application. The bioinformatic strategies based on the SNP (single nucleotide polymorphism) linkage analysis are more practical, which can be divided into two types depending on whether proband information is needed. Hidden Markov Mode (HMM) and Sequential probability ratio test (SPRT) are suitable for families with probands. In contrast, methods based on databases and population demographic information are suitable for families without probands.
    Methods: In this study, we proposed a Spearman rank correlation analysis method to infer the fetal haplotypes based on core family information. Allele frequencies of SNPs that were used to construct parental haplotypes were calculated as sets of nonparametric variables, in contrast to their theoretical values represented by a fetal fraction (FF). The effects on the calculation of the fetal concentration of two DNA enrichment methods, multiple-PCR amplification, and targeted hybrid capture, were compared, and the heterozygosity distribution of SNPs within pedigrees was analyzed to reveal the best conditions for the model application.
    Results: Predictions of the paternal haplotype inheritance were in line with expectations for both DNA library construction methods, while for maternal haplotype inheritance prediction, the rates were 96.55% for method multiple-PCR amplification and 95.8% for method targeted hybrid capture.
    Conclusion: Positive prediction rates showed that the maternal haplotype prediction was not as accurate as paternal one, due to the large amount of maternal noise in the mother's peripheral blood. Although this model is relatively immature, it provides a new perspective for noninvasive prenatal clinical tests of monogenic diseases.
    Mesh-Begriff(e) Female ; Fetus ; Haplotypes ; Humans ; Noninvasive Prenatal Testing ; Pedigree ; Pregnancy ; Prenatal Diagnosis/methods
    Sprache Englisch
    Erscheinungsdatum 2022-05-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.1988
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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