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  1. Artikel ; Online: Effect of EPOC on Serum MicroRNA Expression in Patients with Hypertension

    Hao Li

    Journal of Healthcare Engineering, Vol

    2022  Band 2022

    Abstract: In order to analyze the effect of EPOC on serum microRNA expression in patients with hypertension, we have carried out an experimental evaluation and presented a dedicated method to improve its effectiveness. For this purpose, 60 patients with ... ...

    Abstract In order to analyze the effect of EPOC on serum microRNA expression in patients with hypertension, we have carried out an experimental evaluation and presented a dedicated method to improve its effectiveness. For this purpose, 60 patients with hypertension treated in our hospital from January to December 2020 were selected and randomly divided into the EPOC group (30 cases) and the control group (30 cases). Patients in both groups received conventional hypertension medication according to the treatment guidelines, and education and guidance were strengthened to ensure patients’ drug compliance. The EPOC group received EPOC training in addition to conventional medication. After the intervention, 6MWD, LVEF, and LVEDD in the control group and the EPOC group were significantly improved compared with that before treatment (P < 0.05). The improvement of cardiac function in the EPOC group was significantly better than that in the control group (P < 0.05). Physiological function, physiological characteristics, body pain, and general health of the control group and the EPOC group were significantly improved compared with that before treatment (P < 0.05). The improvement of quality of life in the EPOC group was significantly better than that in the control group (P < 0.05). The indexes of heart rate, oxygen pulse, minute ventilation, oxygen uptake in kg, and anaerobic threshold in the EPOC group were significantly better than those in the control group before and after treatment (P < 0.05). Full-sample real-time PCR verification of the 8 miRNAs with the highest expression differentiation showed that, compared with the control group, the expression levels of miR-20a-5p, miR-93-5p, and miR-1287-5p in the serum of the EPOC group were significantly increased, while the expression levels of miR-7706, miR-28-5p, and miR-125b-5p were significantly decreased. The expression of miR-20a-5p was the highest, while the expression of miR-125b-5p was the lowest, suggesting that miR-20a-5p and miR-125b-5p might be ...
    Schlagwörter Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Hua Guofeng and China’s transformation in the early years of the post-Mao era

    Hao Li-Ogawa

    Journal of Contemporary East Asia Studies, Vol 0, Iss 0, Pp 1-

    2022  Band 19

    Abstract: This article analyzes how Hua Guofeng contributed to China’s transformation in the early years of the post-Mao era. In approaching the central question, five sub-questions are discussed: What kind of transformation took place? Why did Hua initiate the ... ...

    Abstract This article analyzes how Hua Guofeng contributed to China’s transformation in the early years of the post-Mao era. In approaching the central question, five sub-questions are discussed: What kind of transformation took place? Why did Hua initiate the transformation? How did Hua legitimize the transformation? Why was he able to initiate it? And why did he step down in such a short period? Soon after Mao’s death, Hua Guofeng pursued a new course of development and stability. Due to his early career, Hua was a consistent developmentalist as well as a balanced “political generalist.” Hua employed a strategy of “political falsification” and carried out de facto de-Maoization under Mao’s name. Institutional power, his privilege as Mao’s successor, and a broad supporting coalition gave Hua enough power and authority to lead China’s transformation. However, Hua had his limits and weaknesses. Hua’s contribution was significant, but it should not be overestimated.
    Schlagwörter hua guofeng ; cultural revolution ; deng xiaoping ; transformation ; de-maoization ; Political institutions and public administration - Asia (Asian studies only) ; JQ1-6651 ; Social sciences and state - Asia (Asian studies only) ; H53
    Thema/Rubrik (Code) 950
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Taylor & Francis Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Finite–Discrete Element Method Prediction of Advanced Fractures in Extra-Thick Coal Seams Based on a Constitutive Model of Rock Deformation–Fragmentation Failure Process

    Guoqiang Guo / Hao Li

    Processes, Vol 11, Iss 675, p

    2023  Band 675

    Abstract: Roof fall is a frequent and destructive disaster in the working face of extra-thick coal seams. The important technology for disaster elimination is roof grouting, and the key to its success is to accurately predict the distance of the advanced fractures ...

    Abstract Roof fall is a frequent and destructive disaster in the working face of extra-thick coal seams. The important technology for disaster elimination is roof grouting, and the key to its success is to accurately predict the distance of the advanced fractures based on a reasonable rock constitutive relationship. In this paper, the constitutive relationship reflecting the progressive failure process of rock was established, including the elastic–plastic constitutive relation of intact rock, the fracture constitutive relation of non-penetrating fracture, and the shear friction constitutive relation of penetrating fracture. On this basis, the finite–discrete element method (FDEM) numerical calculation method was developed. Taking Yushupo Coal mine with a 16-m-thick coal seam as an example, the numerical results showed that the fractures in the roof appear 15~35 m ahead of the working face, and the maximum value of advance bearing pressure is between 16 and 30 MPa. Meanwhile the laboratory test results showed that the compressive strength of the grouted coal is 14.91 MPa after solidification for 7d. The above data mean that the grouting slurry can solidify the broken roof into a whole without roof fall disaster. At the same time, the rock pressure of the extra-thick coal seam can effectively crush the top coal, which is conducive to the top-coal caving operation. The in situ test shows that when the pre-grouting is carried out in the range of 20~30 m in front of the working face, the roof fall disaster can be effectively avoided, which is consistent with the numerical simulation results. It shows the rationality of the FDEM numerical method and the constitutive model of rock deformation–fragmentation failure process.
    Schlagwörter constitutive model ; finite–discrete element method ; extra-thick coal seam ; roof fall disaster ; pre-grouting technology ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 670
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection

    Hao Li / Xin Jin

    eLife, Vol

    2023  Band 12

    Abstract: The basal ganglia are known to be essential for action selection. However, the functional role of basal ganglia direct and indirect pathways in action selection remains unresolved. Here, by employing cell-type-specific neuronal recording and manipulation ...

    Abstract The basal ganglia are known to be essential for action selection. However, the functional role of basal ganglia direct and indirect pathways in action selection remains unresolved. Here, by employing cell-type-specific neuronal recording and manipulation in mice trained in a choice task, we demonstrate that multiple dynamic interactions from the direct and indirect pathways control the action selection. While the direct pathway regulates the behavioral choice in a linear manner, the indirect pathway exerts a nonlinear inverted-U-shaped control over action selection, depending on the inputs and the network state. We propose a new center (direct)-surround (indirect)-context (indirect) ‘Triple-control’ functional model of basal ganglia, which can replicate the physiological and behavioral experimental observations that cannot be simply explained by either the traditional ‘Go/No-go’ or more recent ‘Co-activation’ model. These findings have important implications on understanding the basal ganglia circuitry and action selection in health and disease.
    Schlagwörter basal ganglia ; action selection ; optogenetics ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 629
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Flow Simulation and Influence Factors Analysis of CO2 Foam Fracturing in Annulus Injection

    Hao Li / Genbo Peng

    Frontiers in Earth Science, Vol

    2022  Band 9

    Abstract: CO2 foam fracturing fluid is widely used in unconventional oil and gas production because of its easy flowback and low damage to the reservoir. Nowadays, the fracturing process of CO2 foam fracturing fluid injected by coiled tubing is widely used. ... ...

    Abstract CO2 foam fracturing fluid is widely used in unconventional oil and gas production because of its easy flowback and low damage to the reservoir. Nowadays, the fracturing process of CO2 foam fracturing fluid injected by coiled tubing is widely used. However, the small diameter of coiled tubing will cause a large frictional pressure loss in the process of fluid flow, which is not beneficial to the development of fracturing construction. In this paper, the temperature and pressure calculation model of gas, liquid, and solid three-phase fluid flow in the wellbore under annulus injection is established. The model accuracy is verified by comparing the calculation results with the existing gas, solid, and gas and liquid two-phase model of CO2 fracturing. The calculation case of this paper shows that compared with the tubing injection method, the annulus injection of CO2 foam fracturing fluid reduces the friction by 3.06 MPa, and increases the wellbore pressure and temperature by 3.06 MPa and 5.77°C, respectively. Increasing the injection temperature, proppant volumetric concentration, and foam quality will increase the wellbore fluid temperature and make the CO2 transition to the supercritical state while increasing the mass flow rate will do the opposite. The research results verify the feasibility of the annulus injection of CO2 foam fracturing fluid and provide a reference for the improvement of CO2 foam fracturing technology in the field.
    Schlagwörter CO2 foam ; temperature distribution ; pressure distribution ; multi-field coupling ; annulus injection ; Science ; Q
    Thema/Rubrik (Code) 600
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Stackelberg Game Analysis of E-Waste Recycling Stakeholders under Recovery Time Sensitivity and CRMs Life Expectancy Sensitivity

    Shu-Hao Li / Qiang Sun

    Sustainability, Vol 14, Iss 9054, p

    2022  Band 9054

    Abstract: In order to discuss the participation selection strategy of relevant subjects in WEEE recycling, a Stackelberg game model of “recyclers—remanufacturers—government” in a WEEE recycling network is constructed, and the system’s stability strategy and ... ...

    Abstract In order to discuss the participation selection strategy of relevant subjects in WEEE recycling, a Stackelberg game model of “recyclers—remanufacturers—government” in a WEEE recycling network is constructed, and the system’s stability strategy and conditions are analyzed. Besides this, the direct and indirect effects of recovery time sensitivity, CRMs’ life expectancy sensitivity, and government subsidies on the optimal decision-making of both recyclers and remanufacturers are explored. The results show that the system can achieve a stable and ideal equilibrium, and achieve win–win for all parties, through reasonable profit transfer and cost-sharing. The dual sensitivity of manufacturers’ demand and policy subsidies has the same qualitative impact on the decision variables of the recyclers and remanufacturers. The subsidies vary depending on the CRMs’ recovery effort level of remanufacturers, and these can incentivize the remanufacturers to increase CRMs’ life expectancy. Moreover, a cost-sharing contract between recyclers and remanufacturers can avoid “free-riding” behavior in WEEE recycling. The research can assist in the benefit coordination and behavior adjustment of WEEE recycling members, and provide a theoretical basis for governments to formulate appropriate recycling subsidies to promote the formal recycling of E-waste.
    Schlagwörter WEEE recycling network ; recovery time sensitivity ; CRMs’ life expectancy sensitivity ; cost-sharing ; Stackelberg model ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Palladium-Catalyzed Aminosulfonylation of

    Qi, Zhenjie / Wen, Simiaomiao / Hao Li / Liu, Shuai / Jiang, Dongfang

    Organic letters

    2023  Band 25, Heft 40, Seite(n) 7322–7326

    Abstract: A simple and efficient Pd-catalyzed oxidative cyclization system is developed for the chemo- and regioselective synthesis of 3,4-dihydro-benzothiadiazine 1,1-dioxides, which are formed through aminosulfonylation ... ...

    Abstract A simple and efficient Pd-catalyzed oxidative cyclization system is developed for the chemo- and regioselective synthesis of 3,4-dihydro-benzothiadiazine 1,1-dioxides, which are formed through aminosulfonylation of
    Sprache Englisch
    Erscheinungsdatum 2023-10-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c02683
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: PURP

    Shan Zhang / Qinkai Jiang / Hao Li / Bin Cao / Jing Fan

    Big Data Mining and Analytics, Vol 7, Iss 1, Pp 171-

    A Scalable System for Predicting Short-Term Urban TrafficFlow Based on License Plate Recognition Data

    2024  Band 187

    Abstract: Accurate and efficient urban traffic flow prediction can help drivers identify road traffic conditions in real-time, consequently helping them avoid congestion and accidents to a certain extent. However, the existing methods for real-time urban traffic ... ...

    Abstract Accurate and efficient urban traffic flow prediction can help drivers identify road traffic conditions in real-time, consequently helping them avoid congestion and accidents to a certain extent. However, the existing methods for real-time urban traffic flow prediction focus on improving the model prediction accuracy or efficiency while ignoring the training efficiency, which results in a prediction system that lacks the scalability to integrate real-time traffic flow into the training procedure. To conduct accurate and real-time urban traffic flow prediction while considering the latest historical data and avoiding time-consuming online retraining, herein, we propose a scalable system for Predicting short-term URban traffic flow in real-time based on license Plate recognition data (PURP). First, to ensure prediction accuracy, PURP constructs the spatio-temporal contexts of traffic flow prediction from License Plate Recognition (LPR) data as effective characteristics. Subsequently, to utilize the recent data without retraining the model online, PURP uses the nonparametric method k-Nearest Neighbor (namely KNN) as the prediction framework because the KNN can efficiently identify the top-k most similar spatio-temporal contexts and make predictions based on these contexts without time-consuming model retraining online. The experimental results show that PURP retains strong prediction efficiency as the prediction period increases.
    Schlagwörter traffic flow prediction ; k-nearest neighbor (knn) ; license plate recognition (lpr) data ; spatio-temporal context ; Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 004
    Sprache Englisch
    Erscheinungsdatum 2024-03-01T00:00:00Z
    Verlag Tsinghua University Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Active machine learning model for the dynamic simulation and growth mechanisms of carbon on metal surface

    Di Zhang / Peiyun Yi / Xinmin Lai / Linfa Peng / Hao Li

    Nature Communications, Vol 15, Iss 1, Pp 1-

    2024  Band 10

    Abstract: Abstract Substrate-catalyzed growth offers a highly promising approach for the controlled synthesis of carbon nanostructures. However, the growth mechanisms on dynamic catalytic surfaces and the development of more general design strategies remain ... ...

    Abstract Abstract Substrate-catalyzed growth offers a highly promising approach for the controlled synthesis of carbon nanostructures. However, the growth mechanisms on dynamic catalytic surfaces and the development of more general design strategies remain ongoing challenges. Here we show how an active machine-learning model effectively reveals the microscopic processes involved in substrate-catalyzed growth. Utilizing a synergistic approach of molecular dynamics and time-stamped force-biased Monte Carlo methods, augmented by the Gaussian Approximation Potential, we perform fully dynamic simulations of graphene growth on Cu(111). Our findings accurately replicate essential subprocesses–from the preferred diffusion of carbon monomer/dimer, chain or ring formations to edge-passivated Cu-aided graphene growth and bond breaks by ion impacts. Extending our simulations to carbon deposition on metal surfaces like Cu(111), Cr(110), Ti(001), and oxygen-contaminated Cu(111), our results align closely with experimental observations, providing a practical and efficient approach for designing metallic or alloy substrates to achieve desired carbon nanostructures and explore further reaction possibilities.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: A case report on Rubinsein-Taybi syndrome associated with a de novo CREBBP gene mutation.

    Li, Zheng / Li, Zi-Jin / Hao, Li-Hong

    Asian journal of surgery

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.04.033
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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