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  1. Article ; Online: TLR22-Induced Pro-Apoptotic mtROS Abets UPR

    Kumar, Manmohan / Sharma, Shagun / Haque, Munira / Kumar, Jai / Hathi, Umesh Prasad Sah / Mazumder, Shibnath

    Frontiers in immunology

    2022  Volume 13, Page(s) 931021

    Abstract: Toll-like receptors (TLRs) are epitomized as the first line of defense against pathogens. Amongst TLRs, TLR22 is expressed in non-mammalian aquatic vertebrates, including fish. Using headkidney macrophages (HKM) ... ...

    Abstract Toll-like receptors (TLRs) are epitomized as the first line of defense against pathogens. Amongst TLRs, TLR22 is expressed in non-mammalian aquatic vertebrates, including fish. Using headkidney macrophages (HKM) of
    MeSH term(s) Aeromonas hydrophila ; Animals ; Caspase 9/metabolism ; Catfishes ; Macrophages ; Mitochondrial Dynamics ; Toll-Like Receptors/metabolism
    Chemical Substances Toll-Like Receptors ; Caspase 9 (EC 3.4.22.-)
    Language English
    Publishing date 2022-07-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.931021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Esculetin unveiled: Decoding its anti-tumor potential through molecular mechanisms-A comprehensive review.

    Rezoan Hossain, Md / Zahra Shova, Fatema Tuj / Akter, Munni / Shuvo, Shahporan / Ahmed, Nasim / Akter, Afroza / Haque, Munira / Salma, Umme / Roman Mogal, Md / Saha, Hasi Rani / Sarkar, Bidhan Chandra / Sohel, Md

    Cancer reports (Hoboken, N.J.)

    2023  Volume 7, Issue 1, Page(s) e1948

    Abstract: Background: The growing complexity of cancer has made it a significant concern in the medical community. Although cancer research has advanced, it is still challenging to create new effective medications due to the limitations and side effects of ... ...

    Abstract Background: The growing complexity of cancer has made it a significant concern in the medical community. Although cancer research has advanced, it is still challenging to create new effective medications due to the limitations and side effects of existing treatment strategies. These are enforcing the development of some alternative drugs from natural compounds with fewer drawbacks and side effects.
    Aim: Therefore, this review aims to provide up-to-date, crucial, and all-encompassing data on esculetin's anticancer activity, including all relevant molecular and cellular processes based on in vivo and in vitro investigations.
    Results: According to the literature review, esculetin is available in nature and is effective against 16 different types of cancer. The general mechanism shown by esculetin is modulating signaling cascades and its related pathways, like cell proliferation, cell growth, autophagy, apoptosis, necrosis, inflammation, angiogenesis, metastasis, invasion, and DNA damage. Nanoformulation of esculetin improves this natural product's efficacy by improving water solubility. Esculetin's synergistic effects with both natural substances and conventional treatments have been shown, and this method aids in reversing resistance mechanisms by modulating resistance-related proteins. In addition, it has fewer side effects on humans than other phytochemicals and standard drugs with some good pharmacokinetic features.
    Conclusion: Therefore, until standard chemotherapeutics are available in pharmaceutical markets, esculetin should be used as a therapeutic drug against various cancer types.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Umbelliferones/pharmacology ; Apoptosis ; Signal Transduction
    Chemical Substances esculetin (SM2XD6V944) ; Umbelliferones
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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