Artikel ; Online: Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: a case report and literature review.
World journal of surgical oncology
2016 Band 14, Heft 1, Seite(n) 161
Abstract: Background: Paraneoplastic syndrome generally results from tumor-derived hormones or peptides that cause metabolic derangements. Common metabolic conditions include hyponatremia, hypercalcemia, hypoglycemia, and Cushing's syndrome. Herein, we report a ... ...
Abstract | Background: Paraneoplastic syndrome generally results from tumor-derived hormones or peptides that cause metabolic derangements. Common metabolic conditions include hyponatremia, hypercalcemia, hypoglycemia, and Cushing's syndrome. Herein, we report a very rare case of tongue carcinoma presenting with leukocytosis and hypercalcemia. Case presentation: A 57-year-old man was admitted to our hospital with tongue squamous cell carcinoma (cT4aN0M0, stage IV). He underwent radical resection following preoperative chemoradiotherapy, but locoregional recurrence was detected 2 months after surgery. He presented with marked leukocytosis and hypercalcemia with elevated serum levels of granulocyte colony-stimulating factor (G-CSF) and parathyroid hormone-related protein (PTHrP). He was therefore managed with intravenous fluids, furosemide, prednisolone, elcatonin, and pamidronate. However, the patient died 1 month later of carcinomatous pleuritis following distant metastasis to the lung. Immunohistochemical analyses of the resected specimens revealed positive staining for PTHrP and G-CSF in the cancer cells. Conclusions: In this case, it was considered that tumor-derived G-CSF and PTHrP caused leukocytosis and hypercalcemia. |
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Mesh-Begriff(e) | Carcinoma, Squamous Cell/blood ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Fatal Outcome ; Granulocyte Colony-Stimulating Factor/blood ; Humans ; Hypercalcemia/blood ; Hypercalcemia/drug therapy ; Hypercalcemia/pathology ; Leukocytosis/blood ; Leukocytosis/drug therapy ; Leukocytosis/pathology ; Male ; Middle Aged ; Parathyroid Hormone-Related Protein/blood ; Tongue Neoplasms/blood ; Tongue Neoplasms/drug therapy ; Tongue Neoplasms/pathology |
Chemische Substanzen | PTHLH protein, human ; Parathyroid Hormone-Related Protein ; Granulocyte Colony-Stimulating Factor (143011-72-7) |
Sprache | Englisch |
Erscheinungsdatum | 2016-06-17 |
Erscheinungsland | England |
Dokumenttyp | Case Reports ; Journal Article ; Review |
ZDB-ID | 2118383-1 |
ISSN | 1477-7819 ; 1477-7819 |
ISSN (online) | 1477-7819 |
ISSN | 1477-7819 |
DOI | 10.1186/s12957-016-0918-1 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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