Artikel ; Online: Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6.
2011 Band 71, Heft 3, Seite(n) 447–459
Abstract: Neurons establish specific synaptic connections with their targets, a process that is highly regulated. Numerous cell adhesion molecules have been implicated in target recognition, but how these proteins are precisely trafficked and targeted is poorly ... ...
Abstract | Neurons establish specific synaptic connections with their targets, a process that is highly regulated. Numerous cell adhesion molecules have been implicated in target recognition, but how these proteins are precisely trafficked and targeted is poorly understood. To identify components that affect synaptic specificity, we carried out a forward genetic screen in the Drosophila eye. We identified a gene, named ric1 homologue (rich), whose loss leads to synaptic specificity defects. Loss of rich leads to reduction of N-Cadherin in the photoreceptor cell synapses but not of other proteins implicated in target recognition, including Sec15, DLAR, Jelly belly, and PTP69D. The Rich protein binds to Rab6, and Rab6 mutants display very similar phenotypes as the rich mutants. The active form of Rab6 strongly suppresses the rich synaptic specificity defect, indicating that Rab6 is regulated by Rich. We propose that Rich activates Rab6 to regulate N-Cadherin trafficking and affects synaptic specificity. |
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Mesh-Begriff(e) | Animals ; Cadherins/metabolism ; Drosophila ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Mutation ; Photoreceptor Cells, Invertebrate/metabolism ; Photoreceptor Cells, Invertebrate/physiology ; Signal Transduction/physiology ; Synapses/genetics ; Synapses/metabolism ; Synapses/physiology ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism ; ras Proteins/genetics ; ras Proteins/metabolism |
Chemische Substanzen | Cadherins ; Drosophila Proteins ; RIC protein, Drosophila ; Rab6 protein ; rab GTP-Binding Proteins (EC 3.6.5.2) ; ras Proteins (EC 3.6.5.2) |
Sprache | Englisch |
Erscheinungsdatum | 2011-07-07 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 808167-0 |
ISSN | 1097-4199 ; 0896-6273 |
ISSN (online) | 1097-4199 |
ISSN | 0896-6273 |
DOI | 10.1016/j.neuron.2011.06.040 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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