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  1. Artikel: Prognostic value of right ventricular dilatation on computed tomography pulmonary angiogram for predicting adverse clinical events in severe COVID-19 pneumonia.

    Beyls, Christophe / Vial, Jeremie / Lefebvre, Thomas / Muller, Charlotte / Hanquiez, Thomas / Besserve, Patricia / Guilbart, Mathieu / Haye, Guillaume / Bernasinski, Michael / Huette, Pierre / Dupont, Hervé / Abou-Arab, Osama / Jounieaux, Vincent / Mahjoub, Yazine

    Frontiers in medicine

    2023  Band 10, Seite(n) 1213775

    Abstract: Background: Right ventricle dilatation (RVD) is a common complication of non-intubated COVID-19 pneumonia caused by pro-thrombotic pneumonitis, intra-pulmonary shunting, and pulmonary vascular dysfunction. In several pulmonary diseases, RVD is routinely ...

    Abstract Background: Right ventricle dilatation (RVD) is a common complication of non-intubated COVID-19 pneumonia caused by pro-thrombotic pneumonitis, intra-pulmonary shunting, and pulmonary vascular dysfunction. In several pulmonary diseases, RVD is routinely measured on computed tomography pulmonary angiogram (CTPA) by the right ventricle-to-left ventricle (LV) diameter ratio > 1 for predicting adverse events.
    Objective: The aim of the study was to evaluate the association between RVD and the occurrence of adverse events in a cohort of critically ill non-intubated COVID-19 patients.
    Methods: Between February 2020 and February 2022, non-intubated patients admitted to the Amiens University Hospital intensive care unit for COVID-19 pneumonia with CTPA performed within 48 h of admission were included. RVD was defined by an RV/LV diameter ratio greater than one measured on CTPA. The primary outcome was the occurrence of an adverse event (renal replacement therapy, extracorporeal membrane oxygenation, 30-day mortality after ICU admission).
    Results: Among 181 patients, 62% (
    Conclusion: Right ventricle (RV) dilatation assessed by RV/LV ratio was a common CTPA finding in non-intubated critical patients with COVID-19 pneumonia and was not associated with the occurrence of clinical adverse events.
    Sprache Englisch
    Erscheinungsdatum 2023-07-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1213775
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: COVID-19 Outbreak in France: Setup and Activities of a Mobile Extracorporeal Membrane Oxygenation Team During the First 3 Weeks.

    Haye, Guillaume / Fourdrain, Alex / Abou-Arab, Osama / Berna, Pascal / Mahjoub, Yazine

    Journal of cardiothoracic and vascular anesthesia

    2020  Band 34, Heft 12, Seite(n) 3493–3495

    Mesh-Begriff(e) COVID-19/epidemiology ; COVID-19/therapy ; Extracorporeal Membrane Oxygenation/instrumentation ; Extracorporeal Membrane Oxygenation/methods ; France/epidemiology ; Humans ; Pandemics ; Point-of-Care Systems
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-08
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2020.05.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Almitrine for COVID-19 critically ill patients - a vascular therapy for a pulmonary vascular disease: Three case reports.

    Huette, Pierre / Abou Arab, Osama / Jounieaux, Vincent / Guilbart, Mathieu / Belhout, Mohamed / Haye, Guillaume / Dupont, Hervé / Beyls, Christophe / Mahjoub, Yazine

    World journal of clinical cases

    2021  Band 9, Heft 14, Seite(n) 3385–3393

    Abstract: Background: Several reports with clinical, histological and imaging data have observed the involvement of lung vascular function to explain the severe hypoxemia in coronavirus disease 2019 (COVID-19) patients. It has been hypothesized that an increased ... ...

    Abstract Background: Several reports with clinical, histological and imaging data have observed the involvement of lung vascular function to explain the severe hypoxemia in coronavirus disease 2019 (COVID-19) patients. It has been hypothesized that an increased pulmonary blood flow associated with an impairment of hypoxic pulmonary vasoconstriction is responsible for an intrapulmonary shunt. COVID-19 may lead to refractory hypoxemia (PaO
    Case summary: We report our experience with three patients with refractory hypoxemia treated with almitrine to enhance oxygenation. Low dose almitrine (Vectarion
    Conclusion: Almitrine may be effective and safe to enhance oxygenation in coronavirus disease 2019 patients. Further controlled studies are required.
    Sprache Englisch
    Erscheinungsdatum 2021-05-13
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i14.3385
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Preload Dependency of 2D Right Ventricle Speckle Tracking Echocardiography Parameters in Healthy Volunteers: A Prospective Pilot Study.

    Beyls, Christophe / Bohbot, Yohann / Caboche, Matthieu / Huette, Pierre / Haye, Guillaume / Dupont, Hervé / Mahjoub, Yazine / Osama, Abou-Arab

    Journal of clinical medicine

    2021  Band 11, Heft 1

    Abstract: 1) Background: Right ventricular (RV) strain parameters derived from the analysis of the tricuspid annular displacement (TAD) are emergent two-dimensional speckle tracking echocardiography (2D-STE) parameter used for the quantitative assessment of RV ... ...

    Abstract (1) Background: Right ventricular (RV) strain parameters derived from the analysis of the tricuspid annular displacement (TAD) are emergent two-dimensional speckle tracking echocardiography (2D-STE) parameter used for the quantitative assessment of RV systolic function. Few data are available regarding 2D-STE parameters and their dependency on RV preload. Our aim was to evaluate the effect of an acute change in RV preload on 2D-STE parameters in healthy volunteers. (2) Methods: Acute modification of RV preload was performed by a fluid challenge (FC): an infusion of 500 mL of 0.9% sodium chloride was given over 5 min in supine position. Preload dependency (responder group) was confirmed by a stroke volume increase of at least 10% measured by echocardiography. (3) Results: Among 32 healthy volunteers, 19 (59%) subjects were classified as non-responders and 13 (41%) as responders. In the responder group, the tricuspid annular plane systolic excursion (TAPSE) significantly increased (20 (20-23.5) mm to 24 (20.5-26.5) mm;
    Sprache Englisch
    Erscheinungsdatum 2021-12-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11010019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Effect of the oXiris membrane on microcirculation after cardiac surgery under cardiopulmonary bypass: study protocol for a randomised controlled trial (OXICARD Study).

    Abou-Arab, Osama / Huette, Pierre / Haye, Guillaume / Guilbart, Mathieu / Touati, Gilles / Diouf, Momar / Beyls, Christophe / Dupont, Herve / Mahjoub, Yazine

    BMJ open

    2021  Band 11, Heft 7, Seite(n) e044424

    Abstract: Introduction: Cytokine storm and endotoxin release during cardiac surgery with cardiopulmonary bypass (CPB) have been related to vasoplegic shock and organ dysfunction. We hypothesised that early (during CPB) cytokine adsorption with oXiris membrane for ...

    Abstract Introduction: Cytokine storm and endotoxin release during cardiac surgery with cardiopulmonary bypass (CPB) have been related to vasoplegic shock and organ dysfunction. We hypothesised that early (during CPB) cytokine adsorption with oXiris membrane for patients at high risk of inflammatory syndrome following cardiac surgery may improve microcirculation, endothelial function and outcomes.
    Methods and analysis: The Oxicard trial is a prospective, monocentric trial, randomising 70 patients scheduled for cardiac surgery. The inclusion criterion is patients aged more than 18 years old undergoing elective cardiac surgery under CPB with an expected CPB time >90 min (double valve replacement or valve replacement plus coronary arterial bypass graft). Patients will be allocated to the intervention group (n=35) or the control group (n=35). In the intervention group, oXiris membrane will be used on the Prismaflex device (Baxter) at blood pump flow of 450 mL/min during cardiac surgery under CPB. In the control group, cardiac surgery under CPB will be conducted as usual without oXiris membrane. An intention-to-treat analysis will be performed. The primary endpoint will be the microcirculatory flow index measured by sublingual microcirculation device at day 1 following cardiac surgery. The secondary endpoints will be other microcirculation variables at CPB end, 6 hours after CPB, at day 1 and at day 2. We also aim to evaluate the occurrence of major cardiovascular and cerebral events (eg, myocardial infarction, stroke, ischaemic mesenteric, resuscitated cardiac arrest, acute kidney injury) within the first 30 days. Cumulative catecholamine use, intensive care unit length of stay, endothelium glycocalyx shedding parameters (syndecan-1, heparan-sulfate and hyaluronic acid), inflammatory cytokines (tumour necrosis factor (TNF) alpha, interleukin 1 (IL1) beta, IL 10, IL 6, lipopolysaccharide, endothelin) and endothelial permeability biomarkers (angiopoietin 1, angiopoietin 2, Tie2 soluble receptor and Vascular Endothelial Growth Factor (VEGF) will also be evaluated.
    Ethics and dissemination: Ethical approval has been obtained from the Institutional Review Board of the University Hospital of Amiens (registration number ID RDB: 2019-A02437-50 in February 2020). Results of the study will be disseminated via peer-reviewed publications and presentations at national and international conferences.
    Trial registration number: NCT04201119.
    Mesh-Begriff(e) Adolescent ; Cardiac Surgical Procedures/adverse effects ; Cardiopulmonary Bypass/adverse effects ; Humans ; Microcirculation ; Prospective Studies ; Randomized Controlled Trials as Topic ; Vascular Endothelial Growth Factor A
    Chemische Substanzen Vascular Endothelial Growth Factor A
    Sprache Englisch
    Erscheinungsdatum 2021-07-09
    Erscheinungsland England
    Dokumenttyp Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-044424
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Iatrogenic Acute Type A Aortic Dissection following Elective Cardiopulmonary Bypass.

    Huette, Pierre / Beyls, Christophe / Guilbart, Mathieu / Haye, Guillaume / Vial, Jérémie / Touati, Gilles / Mahjoub, Yazine / Abou-Arab, Osama

    Aorta (Stamford, Conn.)

    2020  Band 8, Heft 5, Seite(n) 155–158

    Abstract: We report a 62-year-old woman who was scheduled for an elective Tirone David valve sparing aortic root replacement under cardiopulmonary bypass. Within the next few hours, the patient developed bilateral acute ischemia of both lower limbs. A thoracic and ...

    Abstract We report a 62-year-old woman who was scheduled for an elective Tirone David valve sparing aortic root replacement under cardiopulmonary bypass. Within the next few hours, the patient developed bilateral acute ischemia of both lower limbs. A thoracic and abdominopelvic computed tomography scan showed acute Type A aortic dissection with a perforation at the brachiocephalic arterial trunk and a complete malperfusion of the inferior mesenteric and iliac arteries.
    Sprache Englisch
    Erscheinungsdatum 2020-12-23
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 2325-4637
    ISSN 2325-4637
    DOI 10.1055/s-0040-1715124
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: COVID-19 Outbreak in France: Setup and Activities of a Mobile Extracorporeal Membrane Oxygenation Team During the First 3 Weeks

    Haye, Guillaume / Fourdrain, Alex / Abou-Arab, Osama / Berna, Pascal / Mahjoub, Yazine

    J. cardiothoracic vasc. anest

    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #32457006
    Datenquelle COVID19

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  8. Artikel ; Online: COVID-19 outbreak in France: Setup and activities of a mobile Extra Corporeal Membrane Oxygenation (ECMO) team during the first 3 weeks

    Haye, Guillaume / Fourdrain, Alex / Abou-Arab, Osama / Berna, Pascal / Mahjoub, Yazine

    J Cardiothorac Vasc Anesth

    Schlagwörter covid19
    Verlag PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1053/j.jvca.2020.05.004
    Datenquelle COVID19

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  9. Artikel ; Online: COVID-19 Outbreak in France

    Haye, Guillaume / Fourdrain, Alex / Abou-Arab, Osama / Berna, Pascal / Mahjoub, Yazine

    Journal of Cardiothoracic and Vascular Anesthesia ; ISSN 1053-0770

    Setup and Activities of a Mobile Extracorporeal Membrane Oxygenation Team During the First 3 Weeks

    2020  

    Schlagwörter Anesthesiology and Pain Medicine ; Cardiology and Cardiovascular Medicine ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    DOI 10.1053/j.jvca.2020.05.004
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Portal Vein Pulsatility as a Dynamic Marker of Venous Congestion Following Cardiac Surgery: An Interventional Study Using Positive End-Expiratory Pressure.

    Huette, Pierre / Guinot, Pierre-Grégoire / Haye, Guillaume / Moussa, Mouhamed Djahoum / Beyls, Christophe / Guilbart, Mathieu / Martineau, Lucie / Dupont, Hervé / Mahjoub, Yazine / Abou-Arab, Osama

    Journal of clinical medicine

    2021  Band 10, Heft 24

    Abstract: We aimed to assess variations in the portal vein pulsatility index (PI) during mechanical ventilation following cardiac surgery.: Method: After ethical approval, we conducted a prospective monocentric study at Amiens University Hospital. Patients ... ...

    Abstract We aimed to assess variations in the portal vein pulsatility index (PI) during mechanical ventilation following cardiac surgery.
    Method: After ethical approval, we conducted a prospective monocentric study at Amiens University Hospital. Patients under mechanical ventilation following cardiac surgery were enrolled. Doppler evaluation of the portal vein (PV) was performed by transthoracic echography. The maximum velocity (VMAX) and minimum velocity (VMIN) of the PV were measured in pulsed Doppler mode. The PI was calculated using the following formula (VMAX - VMIN)/(VMax). A positive end-expiratory pressure (PEEP) incremental trial was performed from 0 to 15 cmH
    Results: In total, 144 patients were screened from February 2018 to March 2019 and 29 were enrolled. Central venous pressure significantly increased for each PEEP increment. Stroke volumes were significantly lower after PEEP incrementation, with 52 mL (50-55) at PEEP 0 cmH
    Conclusion: In the present study, PI appears to be a dynamic marker of the interaction between mechanical ventilation and right heart pressure after cardiac surgery. The PI could be a useful noninvasive tool to monitor venous congestion associated with mechanical ventilation.
    Sprache Englisch
    Erscheinungsdatum 2021-12-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10245810
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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