Artikel ; Online: Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation.
2024 Band 25, Heft 6, Seite(n) 994–1006
Abstract: The lung is constantly exposed to the outside world and optimal adaptation of immune responses is crucial for efficient pathogen clearance. However, mechanisms that lead to lung-associated macrophages' functional and developmental adaptation remain ... ...
| Abstract | The lung is constantly exposed to the outside world and optimal adaptation of immune responses is crucial for efficient pathogen clearance. However, mechanisms that lead to lung-associated macrophages' functional and developmental adaptation remain elusive. To reveal such mechanisms, we developed a reductionist model of environmental intranasal β-glucan exposure, allowing for the detailed interrogation of molecular mechanisms of pulmonary macrophage adaptation. Employing single-cell transcriptomics, high-dimensional imaging and flow cytometric characterization paired with in vivo and ex vivo challenge models, we reveal that pulmonary low-grade inflammation results in the development of apolipoprotein E (ApoE)-dependent monocyte-derived alveolar macrophages (ApoE |
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| Mesh-Begriff(e) | Animals ; Mice ; Adaptation, Physiological/immunology ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; beta-Glucans ; CD11b Antigen/metabolism ; Cell Differentiation ; Lectins, C-Type/metabolism ; Lung/immunology ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/immunology ; Monocytes/metabolism |
| Chemische Substanzen | Apolipoproteins E ; beta-Glucans ; CD11b Antigen ; dectin 1 ; Lectins, C-Type ; Apoe protein, mouse |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-04-26 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2016987-5 |
| ISSN | 1529-2916 ; 1529-2908 |
| ISSN (online) | 1529-2916 |
| ISSN | 1529-2908 |
| DOI | 10.1038/s41590-024-01830-z |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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