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  1. Artikel ; Online: Compassion around the world.

    Hayes, Tammy Flo

    Journal of emergency nursing

    2007  Band 33, Heft 6, Seite(n) 527–528

    Mesh-Begriff(e) Emergency Nursing/methods ; Empathy ; Female ; Humans ; Male ; Military Nursing ; Nurse's Role ; Parent-Child Relations ; Professional-Family Relations
    Sprache Englisch
    Erscheinungsdatum 2007-10-18
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 604632-0
    ISSN 1527-2966 ; 0099-1767
    ISSN (online) 1527-2966
    ISSN 0099-1767
    DOI 10.1016/j.jen.2007.01.021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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  2. Artikel ; Online: Mpox infection protects against re-challenge in rhesus macaques.

    Aid, Malika / Sciacca, Michaela / McMahan, Katherine / Hope, David / Liu, Jinyan / Jacob-Dolan, Catherine / Powers, Olivia / Barrett, Julia / Wu, Cindy / Mutoni, Audrey / Murdza, Tetyana / Richter, Hannah / Velasco, Jason / Teow, Elyse / Boursiquot, Mona / Cook, Anthony / Orekov, Tatyana / Hamilton, Melissa / Pessaint, Laurent /
    Ryan, Alaina / Hayes, Tammy / Martinot, Amanda J / Seaman, Michael S / Lewis, Mark G / Andersen, Hanne / Barouch, Dan H

    Cell

    2023  Band 186, Heft 21, Seite(n) 4652–4661.e13

    Abstract: The mpox outbreak of 2022-2023 involved rapid global spread in men who have sex with men. We infected 18 rhesus macaques with mpox by the intravenous, intradermal, and intrarectal routes and observed robust antibody and T cell responses following all ... ...

    Abstract The mpox outbreak of 2022-2023 involved rapid global spread in men who have sex with men. We infected 18 rhesus macaques with mpox by the intravenous, intradermal, and intrarectal routes and observed robust antibody and T cell responses following all three routes of infection. Numerous skin lesions and high plasma viral loads were observed following intravenous and intradermal infection. Skin lesions peaked on day 10 and resolved by day 28 following infection. On day 28, we re-challenged all convalescent and 3 naive animals with mpox. All convalescent animals were protected against re-challenge. Transcriptomic studies showed upregulation of innate and inflammatory responses and downregulation of collagen formation and extracellular matrix organization following challenge, as well as rapid activation of T cell and plasma cell responses following re-challenge. These data suggest key mechanistic insights into mpox pathogenesis and immunity. This macaque model should prove useful for evaluating mpox vaccines and therapeutics.
    Mesh-Begriff(e) Animals ; Humans ; Male ; Homosexuality, Male ; Macaca mulatta ; Mpox (monkeypox)/immunology ; Sexual and Gender Minorities ; Monkeypox virus/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-09-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.08.023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments

    Piedra-Mora, Cesar / Robinson, Sally R. / Tostanoski, Lisa H. / Dayao, Denise A. E. / Chandrashekar, Abishek / Bauer, Katherine / Wrijil, Linda / Ducat, Sarah / Hayes, Tammy / Yu, Jingyou / Bondzie, Esther A. / McMahan, Katherine / Sellers, Daniel / Giffin, Victoria / Hope, David / Nampanya, Felix / Mercado, Noe B. / Kar, Swagata / Andersen, Hanne /
    Tzipori, Saul / Barouch, Dan H. / Martinot, Amanda J.

    Veterinary pathology. 2022 July, v. 59, no. 4

    2022  

    Abstract: There is a need to standardize pathologic endpoints in animal models of SARS-CoV-2 infection to help benchmark study quality, improve cross-institutional comparison of data, and assess therapeutic efficacy so that potential drugs and vaccines for SARS- ... ...

    Abstract There is a need to standardize pathologic endpoints in animal models of SARS-CoV-2 infection to help benchmark study quality, improve cross-institutional comparison of data, and assess therapeutic efficacy so that potential drugs and vaccines for SARS-CoV-2 can rapidly advance. The Syrian hamster model is a tractable small animal model for COVID-19 that models clinical disease in humans. Using the hamster model, the authors used traditional pathologic assessment with quantitative image analysis to assess disease outcomes in hamsters administered polyclonal immune sera from previously challenged rhesus macaques. The authors then used quantitative image analysis to assess pathologic endpoints across studies performed at different institutions using different tissue processing protocols. The authors detail pathological features of SARS-CoV-2 infection longitudinally and use immunohistochemistry to quantify myeloid cells and T lymphocyte infiltrates during SARS-CoV-2 infection. High-dose immune sera protected hamsters from weight loss and diminished viral replication in tissues and reduced lung lesions. Cumulative pathology scoring correlated with weight loss and was robust in distinguishing IgG efficacy. In formalin-infused lungs, quantitative measurement of percent area affected also correlated with weight loss but was less robust in non-formalin-infused lungs. Longitudinal immunohistochemical assessment of interstitial macrophage infiltrates showed that peak infiltration corresponded to weight loss, yet quantitative assessment of macrophage, neutrophil, and CD3+ T lymphocyte numbers did not distinguish IgG treatment effects. Here, the authors show that quantitative image analysis was a useful adjunct tool for assessing SARS-CoV-2 treatment outcomes in the hamster model.
    Schlagwörter COVID-19 infection ; Mesocricetus auratus ; Severe acute respiratory syndrome coronavirus 2 ; T-lymphocytes ; animal models ; animal pathology ; image analysis ; immunohistochemistry ; lungs ; macrophages ; neutrophils ; quantitative analysis ; therapeutics ; virus replication ; weight loss
    Sprache Englisch
    Erscheinungsverlauf 2022-07
    Umfang p. 648-660.
    Erscheinungsort SAGE Publications
    Dokumenttyp Artikel
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858221095794
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments.

    Piedra-Mora, Cesar / Robinson, Sally R / Tostanoski, Lisa H / Dayao, Denise A E / Chandrashekar, Abishek / Bauer, Katherine / Wrijil, Linda / Ducat, Sarah / Hayes, Tammy / Yu, Jingyou / Bondzie, Esther A / McMahan, Katherine / Sellers, Daniel / Giffin, Victoria / Hope, David / Nampanya, Felix / Mercado, Noe B / Kar, Swagata / Andersen, Hanne /
    Tzipori, Saul / Barouch, Dan H / Martinot, Amanda J

    Veterinary pathology

    2022  Band 59, Heft 4, Seite(n) 648–660

    Abstract: There is a need to standardize pathologic endpoints in animal models of SARS-CoV-2 infection to help benchmark study quality, improve cross-institutional comparison of data, and assess therapeutic efficacy so that potential drugs and vaccines for SARS- ... ...

    Abstract There is a need to standardize pathologic endpoints in animal models of SARS-CoV-2 infection to help benchmark study quality, improve cross-institutional comparison of data, and assess therapeutic efficacy so that potential drugs and vaccines for SARS-CoV-2 can rapidly advance. The Syrian hamster model is a tractable small animal model for COVID-19 that models clinical disease in humans. Using the hamster model, the authors used traditional pathologic assessment with quantitative image analysis to assess disease outcomes in hamsters administered polyclonal immune sera from previously challenged rhesus macaques. The authors then used quantitative image analysis to assess pathologic endpoints across studies performed at different institutions using different tissue processing protocols. The authors detail pathological features of SARS-CoV-2 infection longitudinally and use immunohistochemistry to quantify myeloid cells and T lymphocyte infiltrates during SARS-CoV-2 infection. High-dose immune sera protected hamsters from weight loss and diminished viral replication in tissues and reduced lung lesions. Cumulative pathology scoring correlated with weight loss and was robust in distinguishing IgG efficacy. In formalin-infused lungs, quantitative measurement of percent area affected also correlated with weight loss but was less robust in non-formalin-infused lungs. Longitudinal immunohistochemical assessment of interstitial macrophage infiltrates showed that peak infiltration corresponded to weight loss, yet quantitative assessment of macrophage, neutrophil, and CD3+ T lymphocyte numbers did not distinguish IgG treatment effects. Here, the authors show that quantitative image analysis was a useful adjunct tool for assessing SARS-CoV-2 treatment outcomes in the hamster model.
    Mesh-Begriff(e) Animals ; COVID-19/veterinary ; COVID-19 Vaccines ; Cricetinae ; Disease Models, Animal ; Humans ; Immune Sera ; Immunoglobulin G ; Lung/pathology ; Macaca mulatta ; Mesocricetus ; SARS-CoV-2 ; Weight Loss
    Chemische Substanzen COVID-19 Vaccines ; Immune Sera ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2022-05-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/03009858221095794
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques.

    Yu, Jingyou / Tostanoski, Lisa H / Mercado, Noe B / McMahan, Katherine / Liu, Jinyan / Jacob-Dolan, Catherine / Chandrashekar, Abishek / Atyeo, Caroline / Martinez, David R / Anioke, Tochi / Bondzie, Esther A / Chang, Aiquan / Gardner, Sarah / Giffin, Victoria M / Hope, David L / Nampanya, Felix / Nkolola, Joseph / Patel, Shivani / Sanborn, Owen /
    Sellers, Daniel / Wan, Huahua / Hayes, Tammy / Bauer, Katherine / Pessaint, Laurent / Valentin, Daniel / Flinchbaugh, Zack / Brown, Renita / Cook, Anthony / Bueno-Wilkerson, Deandre / Teow, Elyse / Andersen, Hanne / Lewis, Mark G / Martinot, Amanda J / Baric, Ralph S / Alter, Galit / Wegmann, Frank / Zahn, Roland / Schuitemaker, Hanneke / Barouch, Dan H

    Nature

    2021  Band 596, Heft 7872, Seite(n) 423–427

    Abstract: The emergence of SARS-CoV-2 variants that partially evade neutralizing antibodies poses a threat to the efficacy of current COVID-19 ... ...

    Abstract The emergence of SARS-CoV-2 variants that partially evade neutralizing antibodies poses a threat to the efficacy of current COVID-19 vaccines
    Mesh-Begriff(e) Ad26COVS1 ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Bronchoalveolar Lavage Fluid/virology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Female ; Immunity, Cellular ; Immunity, Humoral ; Macaca mulatta/immunology ; Macaca mulatta/virology ; Male ; Nose/virology ; SARS-CoV-2/growth & development ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; T-Lymphocytes/immunology ; Virus Replication
    Chemische Substanzen Ad26COVS1 (JT2NS6183B) ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2021-06-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-03732-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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