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  1. Artikel ; Online: Pediatric Primary Tympanoplasty Outcomes With Autologous and Non-autologous Grafts.

    Cass, Nathan D / Hebbe, Annika L / Meier, Maxene R / Kaizer, Alexander M / Kalmanson, Olivia A / Stevens, Christina / Tholen, Kaitlyn E / Haville, Salina / Handley, Elyse / Francom, Christian R / Herrmann, Brian W

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2021  Band 43, Heft 1, Seite(n) 94–100

    Abstract: Objective: To compare rates of successful tympanic membrane (TM) closure in primary pediatric tympanoplasty between various autologous and non-autologous tissues.: Methods: A retrospective chart review was performed examining all primary pediatric ... ...

    Abstract Objective: To compare rates of successful tympanic membrane (TM) closure in primary pediatric tympanoplasty between various autologous and non-autologous tissues.
    Methods: A retrospective chart review was performed examining all primary pediatric tympanoplasties over a 20-year period at a single institution.
    Results: In 564 pediatric tympanoplasties, no statistically significant difference existed between success rates of autologous and non-autologous grafts (p = 0.083). Compared with fascia, the hazard ratios (and 95% confidence intervals [CI]) for failure for each graft were as follows: human pericardial collagen (HR 0.90, CI 0.54-1.50, p = 0.680), porcine submucosal collagen (HR 1.07, CI 0.56-2.05, p = 0.830), human acellular dermal collagen (HR 1.66, CI 0.95-2.87, p = 0.073), and "multiple grafts" (HR 0.72, CI 0.26-1.98, p = 0.520). Survival curves demonstrated that 75% of graft failures occurred by 6 months after surgery, the rest occurring between 6 and 12 months postoperatively. Larger perforations encompassing more than or equal to 50% of the TM had lower success rates (HR 1.50, CI 1.02-2.21, p = 0.041) than smaller perforations encompassing less than 50% of the TM. Age was not correlated with success (HR 0.98, CI 0.93-1.03, p = 0.390).
    Conclusion: This study found that non-autologous collagen grafts provide equivalent rates of healing when compared with autologous tissue in primary pediatric tympanoplasty. In addition to the potential for reduced operative time and donor site morbidity, these materials provide a viable graft alternative in fascia-depleted ears.Level of Evidence: Level 4.
    Mesh-Begriff(e) Animals ; Child ; Collagen/therapeutic use ; Humans ; Retrospective Studies ; Swine ; Treatment Outcome ; Tympanic Membrane Perforation/surgery ; Tympanoplasty
    Chemische Substanzen Collagen (9007-34-5)
    Sprache Englisch
    Erscheinungsdatum 2021-09-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000003344
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Percutaneous coronary intervention in patients with stable coronary artery disease and left ventricular systolic dysfunction: insights from the VA CART program.

    Brophy, Todd J / Warsavage, Theodore J / Hebbe, Annika L / Plomondon, Mary E / Waldo, Stephen W / Rao, Sunil V / DeVore, Adam D / Gutierrez, J Antonio / Swaminathan, Rajesh V

    American heart journal

    2021  Band 235, Seite(n) 149–157

    Abstract: Background: Revascularization of ischemic cardiomyopathy by coronary artery bypass grafting has been shown to improve survival among patients with left ventricular ejection fraction (LVEF) ≤35%, but the role of percutaneous coronary intervention (PCI) ... ...

    Abstract Background: Revascularization of ischemic cardiomyopathy by coronary artery bypass grafting has been shown to improve survival among patients with left ventricular ejection fraction (LVEF) ≤35%, but the role of percutaneous coronary intervention (PCI) in this context is incompletely described. This study sought to evaluate the effect of PCI on mortality and hospitalization among patients with stable coronary artery disease and reduced left ventricular ejection fraction.
    Methods: We performed a retrospective analysis comparing PCI with medical therapy among patients with ischemic cardiomyopathy in the Veterans Affairs Health Administration. Patients with angiographic evidence of 1 or more epicardial stenoses amenable to PCI and LVEF ≤35% were included in the analysis. Outcome data were determined by VA and non-VA data sources on mortality and hospital admission.
    Results: From 2008 through 2015, a study sample of 4,628 patients was identified, of which 1,322 patients underwent ad hoc PCI. Patients were followed to a maximum of 3 years. Propensity score weighted landmark analysis was used to evaluate the primary and secondary outcomes. The primary outcome of all-cause mortality was significantly lower in the PCI cohort compared with medical therapy (21.6% vs 30.0%, P <.001). The secondary outcome of all-cause rehospitalization or death was also lower in the PCI cohort (76.5% vs 83.8%, P <.001).
    Conclusions: In this retrospective analysis of patients with ischemic cardiomyopathy with coronary artery disease amenable to PCI and LVEF ≤35%, revascularization by PCI was associated with decreased all-cause mortality and decreased all-cause death or rehospitalization.
    Mesh-Begriff(e) Aged ; Coronary Artery Disease/complications ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/surgery ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/methods ; Propensity Score ; Retrospective Studies ; Risk Factors ; Stroke Volume/physiology ; Systole ; Treatment Outcome ; Ventricular Dysfunction, Left/complications ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left/physiology
    Sprache Englisch
    Erscheinungsdatum 2021-02-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2021.02.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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