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  1. AU="Hinz, L"
  2. TI=Advances and challenges in the management of essential thrombocythemia

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  1. Artikel: Persistent Lactatemia in Mauriac Syndrome.

    El Tobgy, Nada / Hinz, Laura

    Case reports in endocrinology

    2024  Band 2024, Seite(n) 5599984

    Abstract: Mauriac syndrome is a rare disorder that occurs in patients with type 1 diabetes mellitus (T1DM) with glucose levels significantly above target, characterized by hepatomegaly, growth delay, and cushingoid features. Another distinguishing feature of ... ...

    Abstract Mauriac syndrome is a rare disorder that occurs in patients with type 1 diabetes mellitus (T1DM) with glucose levels significantly above target, characterized by hepatomegaly, growth delay, and cushingoid features. Another distinguishing feature of Mauriac syndrome is persistent lactatemia during diabetic ketoacidosis (DKA) management. We present a case of an 18-year-old patient with T1DM who presented in DKA and then developed elevated lactate levels leading to a diagnosis of Mauriac syndrome. The cause of the persistent lactatemia is not well understood though it is likely related to glycogenic hepatopathy causing hepatomegaly, abnormalities in glucose metabolism, and subsequent inappropriate lactate production. Since the liver changes seen in Mauriac syndrome are reversible with optimal blood glucose control, these patients should be connected to intensive psychosocial and medical support to help them improve their blood glucose levels.
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2627633-1
    ISSN 2090-651X ; 2090-6501
    ISSN (online) 2090-651X
    ISSN 2090-6501
    DOI 10.1155/2024/5599984
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch ; Dissertation / Habilitation: Ergebnisse nach Stabilisierung von Verletzungen der Wirbelsäule im thorakolumbalen Übergang mit dem Fixateur interne

    Hinz, Lukas

    2000  

    Verfasserangabe vorgelegt von: Lukas Hinz
    Sprache Deutsch
    Umfang 79 Bl., Ill., graph. Darst.
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Halle <Saale>, Wittenberg, Univ., Diss., 2000
    HBZ-ID HT013368172
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2002 D 2112 bestellbar zur Ausleihe Magazin

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  3. Artikel ; Online: Increasing optical pose estimation accuracy via freeform design and its application to hand-eye calibration.

    Melchert, Nils / Hinz, Lennart / Schindlbeck, Christopher / Reithmeier, Eduard

    Optics express

    2022  Band 30, Heft 9, Seite(n) 14368–14383

    Abstract: For robot-assisted assembly of complex optical systems, the alignment is facilitated by an accurate pose estimation of its components. However, wavefront-based pose estimation is typically ill-conditioned due to the inherent geometry of conventional ... ...

    Abstract For robot-assisted assembly of complex optical systems, the alignment is facilitated by an accurate pose estimation of its components. However, wavefront-based pose estimation is typically ill-conditioned due to the inherent geometry of conventional industrially manufactured optical components. Therefore, we propose a novel approach in this paper to increase wavefront-based pose estimation accuracy via the design of freeform optics. For this purpose, an optimization problem is derived that parameterizes the component's surfaces by a predetermined freeform surface model. To show the efficacy of our approach, we provide simulation results to compare the pose estimation accuracy for a variety of optical designs. As an application example for the resulting improved pose estimation, a hand-eye calibration of a wavefront sensor is performed. This calibration originates from the field of robotics and represents the identification of a sensor coordinate system with respect to a global reference frame. For quantitative evaluation, the calibrating results are first presented with the aid of simulation data. Finally, the practical feasibility is demonstrated using a conventional industrial robot and additively manufactured freeform lenses.
    Sprache Englisch
    Erscheinungsdatum 2022-04-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.455188
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Dissertation / Habilitation ; Online: Entwicklung eines Aptamer-basierenden Verfahrens zum Nachweis von rinderspezifischem Thrombin in Blutmehlen

    Hinz, L.

    2012  

    Schlagwörter ddc:610
    Sprache Deutsch
    Erscheinungsland de
    Dokumenttyp Dissertation / Habilitation ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  5. Dissertation / Habilitation ; Online: Entwicklung eines Aptamer-basierenden Verfahrens zum Nachweis von rinderspezifischem Thrombin in Blutmehlen

    Hinz, L.

    2012  

    Schlagwörter Text ; ddc:610
    Sprache Deutsch
    Erscheinungsland de
    Dokumenttyp Dissertation / Habilitation ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Buch ; Dissertation / Habilitation: Einfluß von Bleomycin auf die Thrombozytenfunktion in vitro

    Hinz, Lioba

    1982  

    Umfang 50 S. : graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Düsseldorf, Univ., Diss., 1982
    HBZ-ID HT003325911
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    89 D 4124 bestellbar zur Ausleihe Magazin

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  7. Artikel ; Online: Pose Estimation and Damage Characterization of Turbine Blades during Inspection Cycles and Component-Protective Disassembly Processes.

    Middendorf, Philipp / Blümel, Richard / Hinz, Lennart / Raatz, Annika / Kästner, Markus / Reithmeier, Eduard

    Sensors (Basel, Switzerland)

    2022  Band 22, Heft 14

    Abstract: Inspection in confined spaces and difficult-to-access machines is a challenging quality assurance task and particularly difficult to quantify and automate. Using the example of aero engine inspection, an approach for the high-precision inspection of ... ...

    Abstract Inspection in confined spaces and difficult-to-access machines is a challenging quality assurance task and particularly difficult to quantify and automate. Using the example of aero engine inspection, an approach for the high-precision inspection of movable turbine blades in confined spaces will be demonstrated. To assess the condition and damages of turbine blades, a borescopic inspection approach in which the pose of the turbine blades is estimated on the basis of measured point clouds is presented. By means of a feature extraction approach, film-cooling holes are identified and used to pre-align the measured point clouds to a reference geometry. Based on the segmented features of the measurement and reference geometry a RANSAC-based feature matching is applied, and a multi-stage registration process is performed. Subsequently, an initial damage assessment of the turbine blades is derived, and engine disassembly decisions can be assisted by metric geometry deviations. During engine disassembly, the blade root is exposed to high disassembly forces, which can damage the blade root and is crucial for possible repair. To check for dismantling damage, a fast inspection of the blade root is executed using the borescopic sensor.
    Sprache Englisch
    Erscheinungsdatum 2022-07-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22145191
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Metal Forming Tool Monitoring Based on a 3D Measuring Endoscope Using CAD Assisted Registration.

    Hinz, Lennart / Kästner, Markus / Reithmeier, Eduard

    Sensors (Basel, Switzerland)

    2019  Band 19, Heft 9

    Abstract: In order to provide timely, reliable, and comprehensive data for the maintenance of highly stressed geometries in sheet-bulk metal forming tools, this article features a possible setup by combining a 3D measuring endoscope with a two-stage kinematic. The ...

    Abstract In order to provide timely, reliable, and comprehensive data for the maintenance of highly stressed geometries in sheet-bulk metal forming tools, this article features a possible setup by combining a 3D measuring endoscope with a two-stage kinematic. The measurement principle is based on the projection of structured light, allowing time-effective measurements of larger areas. To obtain data of proper quality, several hundred measurements are performed which then have to be registered and finally merged into one single point cloud. Factors such as heavy, unwieldy specimens affecting precise alignment. The rotational axes are therefore possibly misaligned and the kinematics and the hand-eye transformation remain uncalibrated. By the use of computer-aided design (CAD) data, registration can be improved, allowing a detailed examination of local features like gear geometries while reducing the sensitivity to detect shape deviations.
    Sprache Englisch
    Erscheinungsdatum 2019-05-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s19092084
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients.

    Hinz, Lisa / Torrella Barrufet, Joan / Heine, Vivi M

    Acta neuropathologica communications

    2019  Band 7, Heft 1, Seite(n) 196

    Abstract: Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient ... ...

    Abstract Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K
    Mesh-Begriff(e) Adolescent ; Brain/metabolism ; Brain/pathology ; Female ; Gene Expression ; Humans ; Rett Syndrome/genetics ; Rett Syndrome/metabolism ; Rett Syndrome/pathology ; Symporters/biosynthesis ; Symporters/genetics ; Young Adult
    Chemische Substanzen SLC12A5 protein, human ; Symporters
    Sprache Englisch
    Erscheinungsdatum 2019-12-03
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-019-0852-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Factors Influencing Inpatient Insulin Management of Adults With Type 1 and Type 2 Diabetes by Residents and Medical Students.

    Hinz, Laura / Sigal, Ronald J / Paolucci, Elizabeth Oddone / McLaughlin, Kevin

    Canadian journal of diabetes

    2020  Band 45, Heft 2, Seite(n) 167–173.e1

    Abstract: Objectives: The day-to-day management of diabetes is often the responsibility of resident physicians in teaching hospitals, yet studies have consistently shown that learners lack confidence and knowledge of inpatient insulin titration. We sought to ... ...

    Abstract Objectives: The day-to-day management of diabetes is often the responsibility of resident physicians in teaching hospitals, yet studies have consistently shown that learners lack confidence and knowledge of inpatient insulin titration. We sought to elucidate factors that influence inpatient management of diabetes by medical learners. We predicted that there would be conscious and unconscious variables at play, and we sought to determine the process by which learners arrived at insulin titration decisions.
    Methods: We administered a survey using a hypothetical case based on script concordance testing in 88 medical students and residents at the University of Calgary. We used multilevel, mixed-effects linear regression and random-effects meta-analysis to compare clerks' and residents' insulin prescribing, confidence in prescribing decisions and concordance with endocrinologists.
    Results: Residents had higher confidence than clerks, yet were less concordant with the insulin decisions of staff endocrinologists. Both residents and clerks prescribed more insulin when the reported blood glucose was higher, or the patient had positive ketones and prescribed less insulin when the patient had hypoglycemic unawareness. Residents prescribed a higher dose of insulin when the charge nurse reported the result compared with a student nurse, but this variable did not significantly impact prescribing by clerks.
    Conclusions: We propose a model in which learner factors (knowledge, confidence, experience), patient variables and perceived expectations influence insulin titration decisions via analytical and heuristic processes. We propose that educational interventions designed to improve inpatient glycemic control must, therefore, address both knowledge and systems factors.
    Mesh-Begriff(e) Adult ; Canada/epidemiology ; Clinical Competence/statistics & numerical data ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Education, Medical/standards ; Education, Medical/statistics & numerical data ; Female ; Health Knowledge, Attitudes, Practice ; Hospitalization/statistics & numerical data ; Hospitals, Teaching/statistics & numerical data ; Humans ; Inpatients ; Insulin/therapeutic use ; Internship and Residency/standards ; Internship and Residency/statistics & numerical data ; Male ; Practice Patterns, Physicians'/statistics & numerical data ; Risk Factors ; Students, Medical
    Chemische Substanzen Insulin
    Sprache Englisch
    Erscheinungsdatum 2020-07-23
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2020.07.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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