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  1. AU="Hochheimer, Nikolas"
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  1. Article ; Online: Tetraspanins.

    Lang, Thorsten / Hochheimer, Nikolas

    Current biology : CB

    2020  Volume 30, Issue 5, Page(s) R204–R206

    Abstract: Lang and Hochheimer introduce the physiological and pathological functions of tetraspanins. ...

    Abstract Lang and Hochheimer introduce the physiological and pathological functions of tetraspanins.
    MeSH term(s) Humans ; Tetraspanins/adverse effects ; Tetraspanins/physiology
    Chemical Substances Tetraspanins
    Language English
    Publishing date 2020-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2020.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Classes of non-conventional tetraspanins defined by alternative splicing.

    Hochheimer, Nikolas / Sies, Ricarda / Aschenbrenner, Anna C / Schneider, Dirk / Lang, Thorsten

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 14075

    Abstract: Tetraspanins emerge as a family of membrane proteins mediating an exceptional broad diversity of functions. The naming refers to their four transmembrane segments, which define the tetraspanins' typical membrane topology. In this study, we analyzed ... ...

    Abstract Tetraspanins emerge as a family of membrane proteins mediating an exceptional broad diversity of functions. The naming refers to their four transmembrane segments, which define the tetraspanins' typical membrane topology. In this study, we analyzed alternative splicing of tetraspanins. Besides isoforms with four transmembrane segments, most mRNA sequences are coding for isoforms with one, two or three transmembrane segments, representing structurally mono-, di- and trispanins. Moreover, alternative splicing may alter transmembrane topology, delete parts of the large extracellular loop, or generate alternative N- or C-termini. As a result, we define structure-based classes of non-conventional tetraspanins. The increase in gene products by alternative splicing is associated with an unexpected high structural variability of tetraspanins. We speculate that non-conventional tetraspanins have roles in regulating ER exit and modulating tetraspanin-enriched microdomain function.
    MeSH term(s) Alternative Splicing ; Endoplasmic Reticulum/metabolism ; Humans ; Isomerism ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Proteomics ; Structure-Activity Relationship ; Tetraspanins/chemistry ; Tetraspanins/metabolism
    Chemical Substances Membrane Proteins ; Tetraspanins
    Language English
    Publishing date 2019-10-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-50267-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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