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  1. Buch: Medical Issues Related to Genetically Modified Plants of Relevance to Switzerland

    Hoffmann-Sommergruber, Karin / Dorsch-Häsler, Karoline

    National Research Programme NRP 59 "Benefits and Risks of the Deliberate Release of Genetically Modified Plants" ; review of international literature

    2012  

    Verfasserangabe Karin Hoffmann-Sommergruber ; Karoline Dorsch-Häsler
    Sprache Englisch
    Umfang 54 S. : graph. Darst.
    Verlag vdf Hochschulverlag AG an der ETH Zürich
    Erscheinungsort Zürich
    Erscheinungsland Schweiz
    Dokumenttyp Buch
    HBZ-ID HT017532920
    ISBN 978-3-7281-3496-7 ; 978-3-7281-3497-4 ; 3-7281-3496-1 ; 3-7281-3497-X
    Datenquelle Katalog ZB MED Ernährung, Umwelt, Agrar

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    Verfügbar in ZB MED Bonn

    SignaturLeihstatusStandort
    134/88 ausleihbar (Lesesaal) Freihandmagazin (U1)

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  2. Artikel ; Online: Rare food allergens.

    Hoffmann-Sommergruber, Karin

    Allergologie select

    2021  Band 5, Seite(n) 29–32

    Abstract: In food allergy, only a restricted number of protein families have been identified to contain allergenic proteins. These can be further grouped into major allergens, responsible for inducing allergic reactions in the majority of patients allergic to the ... ...

    Abstract In food allergy, only a restricted number of protein families have been identified to contain allergenic proteins. These can be further grouped into major allergens, responsible for inducing allergic reactions in the majority of patients allergic to the food source, as compared to minor allergens only affecting a small number of food allergic patients. In addition, rare allergens have only been described for single cases so far. Rare allergens can derive from novel foods, including exotic varieties and foods not yet frequently consumed in certain regions. Also, new or modified processing strategies could induce a higher allergenicity in certain dietary proteins. And finally, low abundancy and/or low allergenic activity may also account for some rare allergens. For allergenic risk assessment, cross-reactivity of novel allergens with already known allergens is in place and facilitates the identification of potential new allergens, while de novo sensitization to yet undefined allergens can only be described retrospectively. This review presents some examples of recently identified rare allergens.
    Sprache Englisch
    Erscheinungsdatum 2021-01-12
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02135E
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  3. Artikel: Homologous tropomyosins from vertebrate and invertebrate: Recombinant calibrator proteins in functional biological assays for tropomyosin allergenicity assessment of novel animal foods

    Morel-Codreanu, Françoise / Verhoeckx, Kitty / Bindslev-Jensen, Carsten / Ollert, Markus W. / Hoffmann-Sommergruber, Karin / Morisset, Martine / Holzhauser, Thomas / Kuehn, Annette

    Clinical & experimental allergy, 50(1):105-116

    2019  

    Abstract: BACKGROUND: Novel foods may provide new protein sources for a growing world population but entail risks of unexpected food-allergic reactions. No guidance on allergenicity assessment of novel foods exists, while for genetically modified (GM) crops it ... ...

    Körperschaft Paul-Ehrlich-Institut
    Abstract BACKGROUND: Novel foods may provide new protein sources for a growing world population but entail risks of unexpected food-allergic reactions. No guidance on allergenicity assessment of novel foods exists, while for genetically modified (GM) crops it includes comparison of sequence identity with known allergens, digestibility tests and IgE serum screening. OBJECTIVE: As a proof of concept, to evaluate non-/allergenic tropomyosins (TMs) regarding their potential as new calibrator proteins in functional biological in vitro assays for the semi-quantitative allergy risk assessment of novel TM-containing animal foods with mealworm TM as an example. METHODS: Purified TMs (shrimp, Penaeus monodon; chicken Gallus gallus; E coli overexpression) were compared by protein sequencing, circular dichroism analysis and in vitro digestion. IgE binding was quantified using shrimp-allergic patients' sera (ELISA). Biological activities were investigated (skin testing; titrated basophil activation tests, BAT), compared to titrated biological mediator release using humanized rat basophil leukaemia (RBL) cells. RESULTS: Shrimp and chicken TMs showed high sequence homology, both alpha-helical structures and thermal stability. Shrimp TM was stable during in vitro gastric digestion, chicken TM degraded quickly. Both TMs bound specific IgE from shrimp-allergic patients (significantly higher for shrimp TM), whereas skin reactivity was mostly positive with only shrimp TM. BAT and RBL cell assays were positive with shrimp and chicken TM, although at up to 100- to 1000-times lower allergen concentrations for shrimp than chicken TM. In RBL cell assays using both TM as calibrators, an activation of effector cells by mealworm TM similar to that by shrimp TM confirmed the already reported high allergenic potency of mealworm TM as a novel protein source. CONCLUSIONS & CLINICAL RELEVANCE: According to current GM crops' allergenicity assessment, non-allergenic chicken TM could falsely be considered an allergen on a weight-of-evidence approach. However, calibrating allergenic potency in functional BAT and RBL cell assays with clinically validated TMs allowed for semi-quantitative discrimination of novel food protein's allergenicity. With TM calibration as a proof of concept, similar systems of homologous protein might be developed to scale on an axis of allergenicity.
    Schlagwörter Lebensmittelallergie ; allergenicity assessment ; chicken ; shrimp ; basophil activation test ; tropomyosin ; shrimp allergy ; rat basophil leukaemia cell mediator release
    Sprache Englisch
    Dokumenttyp Artikel
    Datenquelle Fachrepositorium Lebenswissenschaften

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  4. Artikel ; Online: Molecular allergology and its application in prevention, diagnosis and therapy.

    Podzhilkova, Aleksandra / Nagl, Christoph / Hoffmann-Sommergruber, Karin

    Frontiers in allergy

    2023  Band 4, Seite(n) 1260902

    Abstract: Allergic diseases represent a relevant global health problem, affecting adults and children and posing a significant burden for health care systems. In addition, the disease is still under-recognized and harmonized diagnostic tools and management plans ... ...

    Abstract Allergic diseases represent a relevant global health problem, affecting adults and children and posing a significant burden for health care systems. In addition, the disease is still under-recognized and harmonized diagnostic tools and management plans for patients are still lacking. In this review the most important aspects of the diagnosis of allergic diseases are summarized and the contribution of Molecular allergology to this area is highlighted.
    Sprache Englisch
    Erscheinungsdatum 2023-08-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2023.1260902
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  5. Artikel ; Online: The Molecular Allergology User's Guide version 2.0 is freely available!

    Hoffmann-Sommergruber, Karin / Santos, Alexandra F / Breiteneder, Heimo

    Allergy

    2023  Band 78, Heft 5, Seite(n) 1139–1141

    Mesh-Begriff(e) Humans ; Hypersensitivity/diagnosis ; Immunoglobulin E ; Allergens ; Basophils ; Mast Cells
    Chemische Substanzen Immunoglobulin E (37341-29-0) ; Allergens
    Sprache Englisch
    Erscheinungsdatum 2023-03-30
    Erscheinungsland Denmark
    Dokumenttyp Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15643
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  6. Buch: Allergene Risikoabschätzung einer genetisch modifizierten Maislinie im Vergleich zu der isogenen Kontrolllinie: Evaluierung der möglichen Untersuchungen und deren Aussagekraft

    Hoffmann-Sommergruber, Karin / Wiedermann-Schmidt, Ursula / Benesch, Thomas

    Endbericht zum BMGF-Projekt GZ 70420/0298 - IV/B/12/2005 ; [Report]

    (Forschungsberichte der Sektion IV / Bundesministerium für Gesundheit, Familie und Jugend, Sektion IV ; 2008,4)

    2008  

    Verfasserangabe von Karin Hoffmann-Sommergruber ; Ursula Wiedermann-Schmidt ; Thomas Benesch
    Serientitel Forschungsberichte der Sektion IV / Bundesministerium für Gesundheit, Familie und Jugend, Sektion IV ; 2008,4
    Überordnung
    Sprache Deutsch
    Umfang 82 S., graph. Darst.
    Verlag Bundesministerium für Gesundheit, Familie und Jugend, Sekt. IV
    Erscheinungsort Wien
    Erscheinungsland Österreich
    Dokumenttyp Buch
    Anmerkung Zsfassung in engl. Sprache
    HBZ-ID HT015850678
    ISBN 978-3-902611-25-3 ; 3-902611-25-1
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2009 A 755 bestellbar zur Ausleihe Magazin

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  7. Artikel: Cow's Milk Processing-Friend or Foe in Food Allergy?

    Geiselhart, Sabine / Podzhilkova, Aleksandra / Hoffmann-Sommergruber, Karin

    Foods (Basel, Switzerland)

    2021  Band 10, Heft 3

    Abstract: Cow's milk (CM) is an integral part of our daily diet starting in infancy and continuing throughout our lifetime. Its composition is rich in proteins with a high nutritional value, bioactive components, milk minerals including calcium, and a range of ... ...

    Abstract Cow's milk (CM) is an integral part of our daily diet starting in infancy and continuing throughout our lifetime. Its composition is rich in proteins with a high nutritional value, bioactive components, milk minerals including calcium, and a range of immunoactive substances. However, cow's milk can also induce a range of immune-mediated diseases including non-IgE-mediated food allergies and IgE-mediated food allergies. Cow's milk allergens have been identified and characterized and the most relevant ones can be assigned to both, the whey and casein fraction. For preservation a range of processing methods are applied to make cow's milk and dairy products safe for consumers. However, these methods affect milk components and thus alter the overall immunogenic activity of cow's milk. This review summarizes the current knowledge on cow's milk allergens and immunoactive substances and the impact of the different processes up- or downregulating the immunogenicity of the respective proteins. It highlights the gaps of knowledge of the related disease mechanisms and the still unidentified beneficial immunomodulating compounds of cow's milk.
    Sprache Englisch
    Erscheinungsdatum 2021-03-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10030572
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  8. Artikel ; Online: Poppy Seed Allergy: Molecular Diagnosis and Cross-Reactivity with Tree Nuts.

    Podzhilkova, Aleksandra / Nagl, Christoph / Hummel, Karin / Bindslev-Jensen, Carsten / Eller, Esben / Mortz, Charlotte G / Bublin, Merima / Hoffmann-Sommergruber, Karin

    The journal of allergy and clinical immunology. In practice

    2024  

    Abstract: Background: Poppy seed (PS) can be a cause of severe allergic reactions, especially in individuals with concurrent allergy to tree nuts and other seeds, but diagnostic criteria and sensitization patterns are lacking.: Objective: To assess the role of ...

    Abstract Background: Poppy seed (PS) can be a cause of severe allergic reactions, especially in individuals with concurrent allergy to tree nuts and other seeds, but diagnostic criteria and sensitization patterns are lacking.
    Objective: To assess the role of PS extract and individual allergens in diagnosing PS allergy and their cross-reactivities with tree nuts and buckwheat.
    Methods: Our retrospective study included 36 PS-sensitized patients; 10 with positive and 26 with a negative oral food challenge (OFC). We identified individual PS allergens and compared the diagnostic performance of sIgE to PS extract to its allergens. Cross-reactivities between PS and related allergens from other seeds was assessed by competitive ELISA.
    Results: We identified four novel PS allergens: Pap s 1 (vicilin), Pap s 1 (27-424) (α-hairpinin), Pap s 2 (legumin), and Pap s 3 (small hydrophilic seed protein). Positive OFC correlated with higher PS-sIgE levels and elevated sIgE levels for the PS allergens, except for Pap s 3. PS and α-hairpinin-sIgE effectively differentiated allergic from tolerant patients, with AUC values of 0.95 and 0.94. PS-sIgE >10.00 kU
    Conclusions: This is the most extensive study on poppy seed allergy to date. Poppy seed and α-hairpinin-sIgE are highly sensitive indicators of clinical reactivity to poppy seeds, while vicilin and legumin-sIgE contribute to concurrent sensitization to hazelnut and buckwheat.
    Sprache Englisch
    Erscheinungsdatum 2024-05-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2024.05.001
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  9. Artikel ; Online: Proteomics and its impact on food allergy diagnosis.

    Hoffmann-Sommergruber, Karin

    EuPA open proteomics

    2016  Band 12, Seite(n) 10–12

    Abstract: Food allergies are a relevant health problem and symptoms range from mild to severe life-threatening reactions. With the help of up to date proteomics the causative food allergens can be identified from individual food sources. A short overview on the ... ...

    Abstract Food allergies are a relevant health problem and symptoms range from mild to severe life-threatening reactions. With the help of up to date proteomics the causative food allergens can be identified from individual food sources. A short overview on the application of proteomics to assess the physicochemical properties of food allergens is presented.
    Sprache Englisch
    Erscheinungsdatum 2016-04-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2720503-4
    ISSN 2212-9685 ; 2212-9685
    ISSN (online) 2212-9685
    ISSN 2212-9685
    DOI 10.1016/j.euprot.2016.03.016
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  10. Artikel ; Online: The clinical impact of cross-reactions between allergens on allergic skin diseases.

    Hoffmann-Sommergruber, Karin / Roesner, Lennart M

    Current opinion in allergy and clinical immunology

    2020  Band 20, Heft 4, Seite(n) 374–380

    Abstract: Purpose of review: The route of allergen sensing via the skin appears to influence the immune system towards mounting a type 2 response, especially in genetically predisposed individuals. Allergens recognized this way may derive from microbial, animal, ... ...

    Abstract Purpose of review: The route of allergen sensing via the skin appears to influence the immune system towards mounting a type 2 response, especially in genetically predisposed individuals. Allergens recognized this way may derive from microbial, animal, food, or other plant sources and trigger atopic dermatitis. Allergens can be grouped into families depending on their structure and function, harboring significant structural and sequence similarities. Cross-reactivity between allergens is believed to arise as a consequence, and to underlie the development of further atopic diseases.
    Recent findings: Especially for the plant allergens of the families of PR10-related proteins and profilins, immune cross-reactions have been described. Actual studies support that food and pollen allergens can aggravate skin lesions in patients suffering from atopic dermatitis. Further on, allergens derived from air-borne or skin-borne fungi belong to common allergen families and bear cross-reactivity potential. Cross-reactivity to human homologous proteins, so-called autoallergens, is discussed to contribute to the chronification of atopic dermatitis.
    Summary: Due to high evolutionary conservation, allergic reactions can be triggered by highly homologous members of allergen families on the humoral as well as on the cellular level.
    Mesh-Begriff(e) Allergens/adverse effects ; Allergens/immunology ; Antigens, Fungal/immunology ; Antigens, Plant/adverse effects ; Antigens, Plant/immunology ; Aspergillus/immunology ; Chronic Disease ; Cross Reactions ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/microbiology ; Food Hypersensitivity/genetics ; Food Hypersensitivity/immunology ; Fungal Proteins/immunology ; Genetic Predisposition to Disease ; Humans ; Immunoglobulin E/immunology ; Malassezia/immunology ; Plant Proteins, Dietary/adverse effects ; Plant Proteins, Dietary/immunology ; Pollen/adverse effects ; Pollen/immunology ; Profilins/adverse effects ; Profilins/immunology ; Risk Factors ; Skin/immunology ; Skin/microbiology ; Skin/pathology
    Chemische Substanzen Allergens ; Antigens, Fungal ; Antigens, Plant ; Fungal Proteins ; Plant Proteins, Dietary ; Profilins ; Immunoglobulin E (37341-29-0)
    Sprache Englisch
    Erscheinungsdatum 2020-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000650
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