Artikel: A high-throughput drug discovery pipeline to optimize kidney normothermic machine perfusion.
2022 Band 13, Seite(n) 974615
Abstract: Kidney transplantation is the only definitive therapy for end-stage kidney disease. The shortage of organs for transplantation is the main limitation of this life-saving treatment. Normothermic machine perfusion (NMP) is a novel preservation technique ... ...
| Abstract | Kidney transplantation is the only definitive therapy for end-stage kidney disease. The shortage of organs for transplantation is the main limitation of this life-saving treatment. Normothermic machine perfusion (NMP) is a novel preservation technique with the potential to increase the number of transplantable kidneys through reducing delayed graft function and organ evaluation under physiological conditions. To date, the cellular effects and possible pharmacological interventions during machine perfusion are incompletely understood. A major limitation is the technically complex, time-consuming, and small-scale replication of NMP in rodent models. To overcome this, we developed a 3D-printed, high throughput |
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| Sprache | Englisch |
| Erscheinungsdatum | 2022-09-26 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2564217-0 |
| ISSN | 1664-042X |
| ISSN | 1664-042X |
| DOI | 10.3389/fphys.2022.974615 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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