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  1. Article ; Online: Ethanolic extract of

    Honari, Niloofar / Shaban, Parastoo / Nasseri, Saeed / Hosseini, Mehran

    Journal of complementary & integrative medicine

    2021  Volume 19, Issue 2, Page(s) 261–267

    Abstract: Objectives: Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could ...

    Abstract Objectives: Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could be used as add-on therapy to inhibit inflammation.
    Methods: The ALI model was established via the intra-tracheal (i.t.) administration of LPS (2 mg/kg) to male BALB/c mice. The ALI mice were divided into four groups (n=8 each) which intra-peritoneally (i.p.) treated with repeated doses of saline (model), dexamethasone (2 mg/kg), and AW (150-300 mg/kg) 1, 11 and 23 h post LPS administration. Twenty-four hours after the LPS challenge, bronchoalveolar lavage fluid (BALF) and lung tissue were evaluated for inflammatory cell influx, level of tumor necrosis factor-α (TNF-α) and histopathological changes.
    Results: The AW (150-300 mg/kg) treated mice showed lower inflammatory cells infiltration in BALF and TNF-α level when compared to the model group. In addition, LPS induced several pathological alterations such as edema, alveolar hemorrhage and inflammatory cell infiltration into the interstitium and alveolar spaces. Treatment with AW significantly reduced LPS-induced pathological injury.
    Conclusions: Taken together, the data here indicated that AW may be considered as a promising add-on therapy for ALI.
    MeSH term(s) Achillea ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/pathology ; Animals ; Anti-Inflammatory Agents/adverse effects ; Inflammation/drug therapy ; Iran ; Lipopolysaccharides/adverse effects ; Lung/pathology ; Mice ; Mice, Inbred BALB C ; Plant Extracts/adverse effects ; Tumor Necrosis Factor-alpha
    Chemical Substances Anti-Inflammatory Agents ; Lipopolysaccharides ; Plant Extracts ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2021-05-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2197618-1
    ISSN 1553-3840 ; 2194-6329
    ISSN (online) 1553-3840
    ISSN 2194-6329
    DOI 10.1515/jcim-2021-0045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice.

    Shaban, Parastoo / Honari, Niloofar / Erfanian, Nafiseh / Hosseini, Mehran / Safarpour, Hossein / Nasseri, Saeed

    Iranian journal of allergy, asthma, and immunology

    2023  Volume 22, Issue 3, Page(s) 281–289

    Abstract: Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J ... ...

    Abstract Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z.J extracts, respectively. 24 h after intratracheal administration of LPS, bronchoalveolar lavage fluid and lung tissues were harvested and assessed for inflammatory cell influx, tumor necrosis factor-α (TNF-α) levels, and histological assessments. Treatment with Z.J extracts (100 and 200 mg/kg) and dexamethasone effectively reduced LPS-induced neutrophil and other inflammatory cell influx into the lung tissue compared to the untreated group. additionally, both doses of Z.J extracts (100 and 200 mg/kg) significantly ameliorated the lung wet-to-dry ratio and histopathological damage. Furthermore, compared to the untreated ALI mice, Z.J extract at the highest dose could significantly reduce the TNF-α level.   The present findings indicated that Z.J could effectively ameliorate LPS-induced ALI inflammatory responses and might be considered a promising alternative therapy for the ALI phenotype.
    MeSH term(s) Mice ; Male ; Animals ; Lipopolysaccharides/pharmacology ; Ziziphus ; Tumor Necrosis Factor-alpha ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/pathology ; Lung/pathology ; Bronchoalveolar Lavage Fluid ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Dexamethasone/adverse effects ; Mice, Inbred BALB C ; NF-kappa B
    Chemical Substances Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Anti-Inflammatory Agents ; Dexamethasone (7S5I7G3JQL) ; NF-kappa B
    Language English
    Publishing date 2023-06-16
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2488724-9
    ISSN 1735-5249 ; 1735-1502
    ISSN (online) 1735-5249
    ISSN 1735-1502
    DOI 10.18502/ijaai.v22i3.13056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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