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  1. Buch: Encyclopedia of AIDS / volume 3

    Hope, Thomas J. / Richman, Douglas D. / Stevenson, Mario

    2018  

    Verfasserangabe Thomas J. Hope, Douglas D. Richman, Mario Stevenson editors-in-chief
    Überordnung Encyclopedia of AIDS
    Sprache Englisch
    Umfang lx Seiten, Seite 1430 - 2192, Illustrationen
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT019698185
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Buch ; Überordnung: Encyclopedia of AIDS

    Hope, Thomas J. / Richman, Douglas D. / Stevenson, Mario

    (Springer reference)

    2018  

    Verfasserangabe Thomas J. Hope, Douglas D. Richman, Mario Stevenson editors-in-chief
    Serientitel Springer reference
    Schlagwörter AIDS ; HIV ; Immunology ; Infectious Diseases ; Virology
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsverlauf 2018-2018
    Umfang 3 Bände
    Verlag Springer
    Erscheinungsort New York, NY
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch ; Überordnung (Einzelbände anzeigen)
    HBZ-ID HT019686669
    ISBN 978-1-4939-7100-8 ; 1-4939-7100-X ; 9781493971015 ; 9781493971022 ; 1493971018 ; 1493971026
    DOI 10.1007/978-1-4939-7101-5
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Buch: Encyclopedia of AIDS / volume 2

    Hope, Thomas J. / Richman, Douglas D. / Stevenson, Mario

    2018  

    Verfasserangabe Thomas J. Hope, Douglas D. Richman, Mario Stevenson editors-in-chief
    Überordnung Encyclopedia of AIDS
    Sprache Englisch
    Umfang lx Seiten, Seite 600 - 1427, Illustrationen
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT019698181
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Buch: Encyclopedia of AIDS / volume 1

    Hope, Thomas J. / Richman, Douglas D. / Stevenson, Mario

    2018  

    Verfasserangabe Thomas J. Hope, Douglas D. Richman, Mario Stevenson editors-in-chief
    Überordnung Encyclopedia of AIDS
    Sprache Englisch
    Umfang lx, 598 Seiten, Illustrationen
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT019698170
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Artikel ; Online: Infectious Virus Tracking by Fluorescent Live Cell Imaging in Primary Cells.

    Gambut, Stephanie / Hope, Thomas J / Mamede, João I

    Methods in molecular biology (Clifton, N.J.)

    2024  Band 2807, Seite(n) 3–14

    Abstract: To successfully infect a cell, HIV-1 has to overcome several host barriers while exploiting cellular cofactors. HIV-1 infection is highly inefficient with the great majority of viral particles not being able to successfully integrate into the target cell ...

    Abstract To successfully infect a cell, HIV-1 has to overcome several host barriers while exploiting cellular cofactors. HIV-1 infection is highly inefficient with the great majority of viral particles not being able to successfully integrate into the target cell genome. Nonproductive HIV-1 particles are degraded or accumulated in cellular compartments. Thus, it becomes hard to distinguish between viral behaviors that lead to effectively infecting the cell from the ones that do not by using traditional methods. Here, we describe the infectious virus tracking method that detects and quantifies individual fluorescent viral particles over time and links viral particle behavior to its infectivity. This method employs live-cell imaging at ultra-low MOIs to detect the outcome of infection for every HIV-1 particle.
    Mesh-Begriff(e) HIV-1/physiology ; Humans ; Virion ; HIV Infections/virology ; Microscopy, Fluorescence/methods ; Cells, Cultured
    Sprache Englisch
    Erscheinungsdatum 2024-05-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3862-0_1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Inflammation weakens HIV prevention.

    Hope, Thomas J

    Nature medicine

    2017  Band 24, Heft 4, Seite(n) 384–385

    Mesh-Begriff(e) Acquired Immunodeficiency Syndrome ; Female ; Genitalia ; HIV ; HIV Infections/prevention & control ; Humans ; Inflammation ; Tenofovir
    Chemische Substanzen Tenofovir (99YXE507IL)
    Sprache Englisch
    Erscheinungsdatum 2017-02-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.4534
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Can a Traditional Chinese Medicine Contribute to a Cure for HIV?

    Hope, Thomas J

    AIDS research and human retroviruses

    2017  Band 33, Heft 2, Seite(n) 89

    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/aid.2017.29001.hop
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Upcoming Implementation of NIH Funding Caps Invites Researcher Feedback.

    Hope, Thomas J

    AIDS research and human retroviruses

    2017  Band 33, Heft 6, Seite(n) iii

    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/aid.2017.29004.tjh
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: VIROLOGY. Visualizing trans-infection.

    Hope, Thomas J

    Science (New York, N.Y.)

    2015  Band 350, Heft 6260, Seite(n) 511–512

    Mesh-Begriff(e) Animals ; HIV Infections/immunology ; HIV-1/physiology ; Humans ; Leukemia Virus, Murine/physiology ; Lymphocytes/virology ; Retroviridae Infections/immunology ; Sialic Acid Binding Ig-like Lectin 1/physiology ; Virus Internalization
    Chemische Substanzen Sialic Acid Binding Ig-like Lectin 1
    Sprache Englisch
    Erscheinungsdatum 2015-10-30
    Erscheinungsland United States
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aad5409
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Barriers of Mucosal Entry of HIV/SIV.

    Carias, Ann M / Hope, Thomas J

    Current immunology reviews

    2019  Band 15, Heft 1, Seite(n) 4–13

    Abstract: Most new HIV infections, over 80%, occur through sexual transmission. During sexual transmission, the virus must bypass specific female and male reproductive tract anatomical barriers to encounter viable target cells. Understanding the generally ... ...

    Abstract Most new HIV infections, over 80%, occur through sexual transmission. During sexual transmission, the virus must bypass specific female and male reproductive tract anatomical barriers to encounter viable target cells. Understanding the generally efficient ability of these barrier to exclude HIV and the precise mechanisms of HIV translocation beyond these genital barriers is essential for vaccine and novel therapeutic development. In this review, we explore the mucosal, barriers of cervico-vaginal and penile tissues that comprise the female and male reproductive tracts. The unique cellular assemblies f the squamous and columnar epithelium are illustrate highlighting their structure and function. Each anatomical tissue offers a unique barrier to virus entry in healthy individuals. Unfortunately barrier dysfunction can lead to HIV transmission. How these diverse mucosal barriers have the potential to fail is considered, highlighting those anatomical areas that are postulated to offer a weaker barrier and are; therefore, more susceptible to viral ingress. Risk factors, such as sexually transmitted infections, microbiome dysbiosis, and high progestin environments are also associated with increased acquisition of HIV. How these states may affect the integrity of mucosal barriers leading to HIV acquisition are discussed suggesting mechanisms of transmission and revealing potential targets for intervention.
    Sprache Englisch
    Erscheinungsdatum 2019-12-11
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 2274820-9
    ISSN 1875-631X ; 1573-3955
    ISSN (online) 1875-631X
    ISSN 1573-3955
    DOI 10.2174/1573395514666180604084404
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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