Artikel ; Online: Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats.
The journal of physiological sciences : JPS
2024 Band 74, Heft 1, Seite(n) 26
Abstract: Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was placed in an ... ...
Abstract | Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was placed in an organ bath, and mechanical responses were recorded using a force transducer. Exogenous application of ATP (10-100 μM) evoked relaxation of the esophageal smooth muscle in a longitudinal direction under the condition of carbachol (1 μM) -induced precontraction. Pretreatment with a non-selective P2 receptor antagonist, suramin (500 μM), and a P2Y receptor antagonist, cibacron blue F3GA (200 μM), inhibited the ATP (100 μM) -induced relaxation, but a P2X receptor antagonist, pyridoxal phosphate-6-azophenyl-2,4-disulfonic acid (50 μM), did not affect it. A blocker of ATP-dependent potassium channels (K |
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Mesh-Begriff(e) | Animals ; Rats ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; Muscle, Smooth/metabolism ; Male ; Receptors, Purinergic P2Y/metabolism ; Esophagus/drug effects ; Esophagus/physiology ; Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; KATP Channels/metabolism ; Muscle Relaxation/drug effects ; Muscle Relaxation/physiology ; Rats, Wistar ; Muscle Contraction/drug effects ; Muscle Contraction/physiology ; Purinergic P2Y Receptor Antagonists/pharmacology ; Gastrointestinal Motility/drug effects ; Gastrointestinal Motility/physiology ; Rats, Sprague-Dawley |
Chemische Substanzen | Receptors, Purinergic P2Y ; Adenosine Triphosphate (8L70Q75FXE) ; KATP Channels ; Purinergic P2Y Receptor Antagonists |
Sprache | Englisch |
Erscheinungsdatum | 2024-04-23 |
Erscheinungsland | Japan |
Dokumenttyp | Journal Article |
ZDB-ID | 2234472-X |
ISSN | 1880-6562 ; 1880-6546 |
ISSN (online) | 1880-6562 |
ISSN | 1880-6546 |
DOI | 10.1186/s12576-024-00916-5 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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