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  1. Artikel: Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis.

    Tsamakis, Konstantinos / Galinaki, Sofia / Alevyzakis, Evangelos / Hortis, Ioannis / Tsiptsios, Dimitrios / Kollintza, Evangelia / Kympouropoulos, Stylianos / Triantafyllou, Konstantinos / Smyrnis, Nikolaos / Rizos, Emmanouil

    Microorganisms

    2022  Band 10, Heft 6

    Abstract: There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota-gut- ... ...

    Abstract There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota-gut-brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations.
    Sprache Englisch
    Erscheinungsdatum 2022-05-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10061121
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis

    Tsamakis, Konstantinos / Galinaki, Sofia / Alevyzakis, Evangelos / Hortis, Ioannis / Tsiptsios, Dimitrios / Kollintza, Evangelia / Kympouropoulos, Stylianos / Triantafyllou, Konstantinos / Smyrnis, Nikolaos / Rizos, Emmanouil

    Microorganisms. 2022 May 29, v. 10, no. 6

    2022  

    Abstract: There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut– ... ...

    Abstract There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut–brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations.
    Schlagwörter autism ; bipolar disorder ; cognition ; humans ; intestinal microorganisms ; microbiome ; pathogenesis ; prognosis ; schizophrenia
    Sprache Englisch
    Erscheinungsverlauf 2022-0529
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10061121
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel: Association of antipsychotic use with raised eosinophil count.

    Tsamakis, Konstantinos / Mueller, Christoph / Hortis, Ioannis / Kallergi, Maria / Tolos, Ioannis / Alevyzakis, Evangelos / Siafakas, Nikolaos / Ouranidis, Andreas / Tsiptsios, Dimitrios / Kympouropoulos, Stylianos / Spandidos, Demetrios A / Smyrnis, Nikolaos / Rizos, Emmanouil

    Experimental and therapeutic medicine

    2021  Band 21, Heft 5, Seite(n) 513

    Abstract: The current study aimed to assess the possibility of an association between first and second generation antipsychotic medication and raised eosinophil count. A total of 22 in-patients at the psychiatric unit of the University General Hospital 'Attikon', ... ...

    Abstract The current study aimed to assess the possibility of an association between first and second generation antipsychotic medication and raised eosinophil count. A total of 22 in-patients at the psychiatric unit of the University General Hospital 'Attikon', a tertiary hospital, were included in the present study. Patients had received antipsychotic monotherapy and did not have any co-morbidities or require additional treatments. Patients were monitored weekly and their eosinophil count was assessed. One-way ANOVA and summary measures analysis were applied to study the effect of time and medication type on the absolute eosinophil concentration (or relative percentage) for each patient. The differences in mean eosinophil concentrations or relative percentage by patient and time were also assessed. An increase in the absolute concentration and the relative percentage of eosinophils over time was observed in patients receiving Olanzapine, Haloperidol and Aripiprazole. However, there was no difference between individual medications. In conclusion, antipsychotics may be associated with increased eosinophil count over time; however, larger studies involving more patients and a longer follow-up are required to reach a definitive conclusion.
    Sprache Englisch
    Erscheinungsdatum 2021-03-19
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.9944
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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