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  1. Article ; Online: Exploring the various effects of Cu doping in hydroxyapatite nanoparticle.

    Noori, Alireza / Hoseinpour, Mahdieh / Kolivand, Sedighe / Lotfibakhshaiesh, Nasrin / Ebrahimi-Barough, Somayeh / Ai, Jafar / Azami, Mahmoud

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3421

    Abstract: Adding foreign ions to hydroxyapatite (HAp) is a popular approach for improving its properties. This study focuses on the effects of calcium substitution with copper in HAp. Instead of calcium, copper ions were doped into the structure of hydroxyapatite ... ...

    Abstract Adding foreign ions to hydroxyapatite (HAp) is a popular approach for improving its properties. This study focuses on the effects of calcium substitution with copper in HAp. Instead of calcium, copper ions were doped into the structure of hydroxyapatite nanoparticles at 1%, 3%, and 5% concentrations. XRD analysis showed that the amount of substituted copper was less than needed to generate a distinct phase, yet its lattice parameters and crystallinity slightly decreased. Further, the results of degradation tests revealed that copper doping in hydroxyapatite doubled calcium ion release in water. The incorporation of copper into the apatite structure also boosted the HAp zeta potential and FBS protein adsorption onto powders. According to antibacterial investigations, a concentration of 200 mg/ml of hydroxyapatite containing 5% copper was sufficient to effectively eradicate E. coli and S. aureus bacteria. Furthermore, copper improved hydroxyapatite biocompatibility. Alkaline phosphatase activity and alizarin red tests showed that copper in hydroxyapatite did not inhibit stem cell differentiation into osteoblasts. Also, the scratch test demonstrated that copper-containing hydroxyapatite extract increased HUVEC cell migration. Overall, our findings demonstrated the utility of incorporating copper into the structure of hydroxyapatite from several perspectives, including the induction of antibacterial characteristics, biocompatibility, and angiogenesis.
    MeSH term(s) Durapatite/chemistry ; Copper/chemistry ; Calcium ; Escherichia coli ; Staphylococcus aureus ; Nanoparticles ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Ions
    Chemical Substances Durapatite (91D9GV0Z28) ; Copper (789U1901C5) ; Calcium (SY7Q814VUP) ; Anti-Bacterial Agents ; Ions
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53704-x
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  2. Article: A review of 3D bio-printing for bone and skin tissue engineering: a commercial approach

    Beheshtizadeh, Nima / Lotfibakhshaiesh, Nasrin / Pazhouhnia, Zahra / Hoseinpour, Mahdieh / Nafari, Masoud

    Journal of materials science. 2020 Mar., v. 55, no. 9

    2020  

    Abstract: The ultimate prospect of tissue engineering is to create autologous tissue grafts for future replacement therapies through utilization of cells and biomaterials simultaneously. Bio-printing is a novel technique, a growing field that is leading to the ... ...

    Abstract The ultimate prospect of tissue engineering is to create autologous tissue grafts for future replacement therapies through utilization of cells and biomaterials simultaneously. Bio-printing is a novel technique, a growing field that is leading to the global revolution in medical sciences that has gained significant attention. Bio-printing has the potential to be used in producing human engineered tissues like bone and skin which then ultimately can be used in the clinics. In this paper, the 3D bio-printing applications of the engineered human tissues that are available (skin and bone) are reviewed. It is evident that various tissue engineering techniques have been applied in the fabrication of skin tissue; therefore, it leads to introduce tissue substitutes such as complementary, split-thickness skin graft, allografts, acellular dermal substitutes and cellularized graft-like commercial products, i.e., Dermagraft and Apligraf. Also, some bone scaffolds based on hydroxyapatite and biphasic calcium phosphate are available in the market. The technology of bio-printing has got validated for bone and skin tissue fabrication, and it is hoped that other tissues could be produced by this technique.
    Keywords allografting ; biocompatible materials ; humans ; hydroxyapatite ; markets ; medical sciences ; tissue engineering ; tissues
    Language English
    Dates of publication 2020-03
    Size p. 3729-3749.
    Publishing place Springer US
    Document type Article
    Note Review
    ZDB-ID 2015305-3
    ISSN 1573-4803 ; 0022-2461
    ISSN (online) 1573-4803
    ISSN 0022-2461
    DOI 10.1007/s10853-019-04259-0
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Synergy effects of copper and L-arginine on osteogenic, angiogenic, and antibacterial activities.

    Noori, Alireza / Hoseinpour, Mahdieh / Kolivand, Sedighe / Lotfibakhshaiesh, Nasrin / Azami, Mahmoud / Ai, Jafar / Ebrahimi-Barough, Somayeh

    Tissue & cell

    2022  Volume 77, Page(s) 101849

    Abstract: Copper (Cu) ions have been found to exert antibacterial and angiogenic effects. However, some studies have indicated that it inhibits osteogenesis at high concentrations. On the other hand, L-arginine (Arg) is a semi-essential amino acid required for ... ...

    Abstract Copper (Cu) ions have been found to exert antibacterial and angiogenic effects. However, some studies have indicated that it inhibits osteogenesis at high concentrations. On the other hand, L-arginine (Arg) is a semi-essential amino acid required for various biological processes, including osteogenic and angiogenic activities. As a result, we hypothesized that combining Arg with Cu ions would reduce its inhibitory effects on osteogenesis while increasing its angiogenic and antibacterial capabilities. To assess osteogenic and angiogenic activities, we employed rat bone marrow mesenchymal stem cells (MSCs) and human umbilical vein endothelial cells (HUVECs), respectively. The gram-positive bacteria Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. aureus), and the gram-negative bacterium Escherichia coli (E. coli) were used to investigate bacterial behaviors. According to ALP activity and calcium deposition outcomes, copper ions inhibited osteogenic development of MSCs at 100 µM; however, Arg supplementation somewhat mitigated the inhibitory effects. Furthermore, Copper and Arg synergistically stimulated migration and tube formation of HUVECs. According to our findings, copper ions and Arg in the range of 1-100 µM had no antibacterial effect on any examined bacteria. However, at a dose of 20 mM, copper demonstrated antibacterial activity, which was boosted by Arg. Overall, these findings suggest that a combination of copper and Arg may be more beneficial for bone regeneration than either copper or Arg alone.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Arginine/pharmacology ; Copper/chemistry ; Copper/pharmacology ; Escherichia coli ; Human Umbilical Vein Endothelial Cells ; Humans ; Ions ; Osteogenesis ; Rats ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents ; Ions ; Copper (789U1901C5) ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2022-06-01
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 204424-9
    ISSN 1532-3072 ; 0040-8166
    ISSN (online) 1532-3072
    ISSN 0040-8166
    DOI 10.1016/j.tice.2022.101849
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    Zs.A 1016: Show issues Location:
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  4. Article ; Online: Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises.

    Basiri, Arefeh / Pazhouhnia, Zahra / Beheshtizadeh, Nima / Hoseinpour, Mahdieh / Saghazadeh, Amene / Rezaei, Nima

    Stem cell reviews and reports

    2020  Volume 17, Issue 1, Page(s) 163–175

    Abstract: Novel coronavirus disease (COVID-19) has attracted much attention around the world due to its rapid transmission among humans and relatively high mortality rate. Studies are increasing to find the best therapeutic approach for the disease and its ... ...

    Abstract Novel coronavirus disease (COVID-19) has attracted much attention around the world due to its rapid transmission among humans and relatively high mortality rate. Studies are increasing to find the best therapeutic approach for the disease and its management. Regenerative medicine offers various cell-tissue therapeutics and related products, such as stem cell therapy, natural killer (NK) cell therapy, Chimeric antigen receptor (CAR) T cell therapy, exosomes, and tissue products. Interestingly, mesenchymal stem cells (MSCs) can reduce inflammatory symptoms and protect against cytokine storm, which critically contributes to the COVID-19 progression. Notably, having the potentials to exert cytotoxic effects on infected cells and induce interferon production probably make NK cells a candidate for COVID-19 cell therapy. Besides, exosomes are one of the crucial products of cells that can exert therapeutic effects through the induction of immune responses and neutralizing antibody titers. The paper aims to briefly consider current options for COVID-19 therapy to show that there is no specific cure for COVID-19, and then assess the real opportunities and range of promises regenerative medicine can provide for specific treatment of COVID-19. Graphical Abstract Therapeutic Potential of Regenerative Medicine against COVID19.
    MeSH term(s) COVID-19/therapy ; COVID-19/virology ; Cell- and Tissue-Based Therapy ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Exosomes/immunology ; Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/immunology ; Regenerative Medicine ; SARS-CoV-2/pathogenicity
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-020-09994-5
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    Zs.A 6198: Show issues Location:
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  5. Article ; Online: Development of Data Mining Algorithms for Identifying the Best Anthropometric Predictors for Cardiovascular Disease: MASHAD Cohort Study.

    Mansoori, Amin / Hosseini, Zeinab Sadat / Ahari, Rana Kolahi / Poudineh, Mohadeseh / Rad, Elias Sadooghi / Zo, Mostafa Mahmoudi / Izadi, Faezeh Salmani / Hoseinpour, Mahdieh / Miralizadeh, Amirreza / Mashhadi, Yalda Alizadeh / Hormozi, Maryam / Firoozeh, Mohadeseh Taj / Hajhoseini, Omolbanin / Ferns, Gordon / Esmaily, Habibollah / Mobarhan, Majid Ghayour

    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

    2023  Volume 30, Issue 3, Page(s) 243–253

    Abstract: Introduction: Many studies have been published to assess the best anthropometric measurements associated with cardiovascular diseases (CVDs), but controversies still exist.: Aim: Investigating the association between CVDs and anthropometric ... ...

    Abstract Introduction: Many studies have been published to assess the best anthropometric measurements associated with cardiovascular diseases (CVDs), but controversies still exist.
    Aim: Investigating the association between CVDs and anthropometric measurements among Iranian adults.
    Methods: For a total population of 9354 aged 35 to 65, a prospective study was designed. Anthropometric measurements including ABSI (A Body Shape Index), Body Adiposity Index (BAI), Body Mass Index (BMI), Waist to Height Ratio (WHtR), Body Round Index (BRI), HC (Hip Circumference), Demispan, Mid-arm circumference (MAC), Waist-to-hip (WH) and Waist Circumference (WC) were completed. The association between these parameters and CVDs were assessed through logistic regression (LR) and decision tree (DT) models.
    Results: During the 6-year follow-up, 4596 individuals (49%) developed CVDs. According to the LR, age, BAI, BMI, Demispan, and BRI, in male and age, WC, BMI, and BAI in female had a significant association with CVDs (p-value < 0.03). Age and BRI for male and age and BMI for female represent the most appropriate estimates for CVDs (OR: 1.07, (95% CI: 1.06, 1.08), 1.36 (1.22, 1.51), 1.14 (1.13, 1.15), and 1.05 (1.02, 1.07), respectively). In the DT for male, those with BRI ≥ 3.87, age ≥ 46 years, and BMI ≥ 35.97 had the highest risk to develop CVDs (90%). Also, in the DT for female, those with age ≥ 54 years and WC ≥ 84 had the highest risk to develop CVDs (71%).
    Conclusion: BRI and age in male and age and BMI in female had the greatest association with CVDs. Also, BRI and BMI was the strongest indices for this prediction.
    MeSH term(s) Adult ; Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/complications ; Cohort Studies ; Risk Factors ; Prospective Studies ; Iran/epidemiology ; Obesity/epidemiology ; Body Mass Index ; Waist Circumference ; Waist-Height Ratio
    Language English
    Publishing date 2023-05-19
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1236337-6
    ISSN 1179-1985 ; 1120-9879
    ISSN (online) 1179-1985
    ISSN 1120-9879
    DOI 10.1007/s40292-023-00577-2
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    Zs.A 4289: Show issues Location:
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  6. Article ; Online: Platelet distribution widths and white blood cell are associated with cardiovascular diseases: data mining approaches.

    Poudineh, Mohadeseh / Mansoori, Amin / Sadooghi Rad, Elias / Hosseini, Zeinab Sadat / Salmani Izadi, Faezeh / Hoseinpour, Mahdieh / Mahmoudi Zo, Mostafa / Ghoflchi, Sahar / Tanbakuchi, Davoud / Nazar, Eisa / Ferns, Gordon / Effati, Sohrab / Esmaily, Habibollah / Ghayour-Mobarhan, Majid

    Acta cardiologica

    2023  Volume 78, Issue 9, Page(s) 1033–1044

    Abstract: Objective: To investigate the association between cardiovascular diseases (CVDs) and haematologic factors in a cohort of Iranian adults.: Method: For a total population of 9,704 aged 35 to 65, a prospective study was designed. Haematologic factors ... ...

    Abstract Objective: To investigate the association between cardiovascular diseases (CVDs) and haematologic factors in a cohort of Iranian adults.
    Method: For a total population of 9,704 aged 35 to 65, a prospective study was designed. Haematologic factors and demographic characteristics (such as gender, age, and smoking status) were completed for all participants. The association between haematologic factors and CVDs was assessed through logistic regression (LR) analysis, decision tree (DT), and bootstrap forest (BF).
    Results: Almost all of the included factors were significantly associated with CVD (
    Conclusion: The obtained result from LR, DT, and BF models confirmed that age, WBC, and PDW are the most crucial factors for the development of CVD.
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 390197-x
    ISSN 1784-973X ; 0001-5385
    ISSN (online) 1784-973X
    ISSN 0001-5385
    DOI 10.1080/00015385.2023.2246199
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  7. Article: Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises

    Basiri, Arefeh / Pazhouhnia, Zahra / Beheshtizadeh, Nima / Hoseinpour, Mahdieh / Saghazadeh, Amene / Rezaei, Nima

    Abstract: Novel coronavirus disease (COVID-19) has attracted much attention around the world due to its rapid transmission among humans and relatively high mortality rate. Studies are increasing to find the best therapeutic approach for the disease and its ... ...

    Abstract Novel coronavirus disease (COVID-19) has attracted much attention around the world due to its rapid transmission among humans and relatively high mortality rate. Studies are increasing to find the best therapeutic approach for the disease and its management. Regenerative medicine offers various cell-tissue therapeutics and related products, such as stem cell therapy, natural killer (NK) cell therapy, Chimeric antigen receptor (CAR) T cell therapy, exosomes, and tissue products. Interestingly, mesenchymal stem cells (MSCs) can reduce inflammatory symptoms and protect against cytokine storm, which critically contributes to the COVID-19 progression. Notably, having the potentials to exert cytotoxic effects on infected cells and induce interferon production probably make NK cells a candidate for COVID-19 cell therapy. Besides, exosomes are one of the crucial products of cells that can exert therapeutic effects through the induction of immune responses and neutralizing antibody titers. The paper aims to briefly consider current options for COVID-19 therapy to show that there is no specific cure for COVID-19, and then assess the real opportunities and range of promises regenerative medicine can provide for specific treatment of COVID-19. Graphical Abstract Therapeutic Potential of Regenerative Medicine against COVID19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #608577
    Database COVID19

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  8. Article ; Online: Regenerative Medicine in COVID-19 Treatment

    Basiri, Arefeh / Pazhouhnia, Zahra / Beheshtizadeh, Nima / Hoseinpour, Mahdieh / Saghazadeh, Amene / Rezaei, Nima

    Stem Cell Reviews and Reports ; ISSN 2629-3269 2629-3277

    Real Opportunities and Range of Promises

    2020  

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s12015-020-09994-5
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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