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  1. Artikel ; Online: Theoretical Insights into the Dynamics of Gas-Phase Bimolecular Reactions with Submerged Barriers

    Hongwei Song / Hua Guo

    ACS Physical Chemistry Au, Vol 3, Iss 5, Pp 406-

    2023  Band 418

    Schlagwörter Physical and theoretical chemistry ; QD450-801
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag American Chemical Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Evinacumab for Homozygous Familial Hypercholesterolemia.

    Xu, Hua-Guo

    The New England journal of medicine

    2021  Band 384, Heft 6, Seite(n) e17

    Mesh-Begriff(e) Antibodies, Monoclonal/therapeutic use ; Homozygote ; Humans ; Hyperlipoproteinemia Type II/drug therapy ; Hyperlipoproteinemia Type II/genetics
    Chemische Substanzen Antibodies, Monoclonal ; evinacumab (T8B2ORP1DW)
    Sprache Englisch
    Erscheinungsdatum 2021-02-05
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2033612
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Single atom catalysis poised to transition from an academic curiosity to an industrially relevant technology

    Abhaya K. Datye / Hua Guo

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 3

    Abstract: During the past decade, initial skepticism rapidly changed into widespread recognition of the role of single atoms in heterogeneous catalysts. The next decade could usher in the era of industrial applications as manufacturing of durable single atom ... ...

    Abstract During the past decade, initial skepticism rapidly changed into widespread recognition of the role of single atoms in heterogeneous catalysts. The next decade could usher in the era of industrial applications as manufacturing of durable single atom catalysts is perfected.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Analysis of clinical research publication patterns to characterize the cooperation among China's "double first-class" construction medical universities: based on social network analysis.

    Jing, Xue / Hua, Guo

    Annals of translational medicine

    2022  Band 10, Heft 6, Seite(n) 320

    Abstract: Background: The "Double First-Class" refers to world first-class university and first-class academic discipline construction proposed by China government. The "Double First-Class" construction medical universities have made many clinical research ... ...

    Abstract Background: The "Double First-Class" refers to world first-class university and first-class academic discipline construction proposed by China government. The "Double First-Class" construction medical universities have made many clinical research achievements, but the analysis and evaluation of research collaboration networks in the field of clinical research are still lacking.
    Methods: Clinical research papers by 23 "Double First-Class" construction medical universities in China from 2000 to 2019 indexed in the databases of the China National Knowledge Infrastructure and Web of Science (WoS) databases were collected. Through the social network analysis (SNA) method and Ucinet software, the interuniversity research cooperation networks of domestic and international publications were comparatively analyzed at the overall, individual, and group levels in terms of number of publications, cooperation network matrix, centrality analysis, cohesive subgroup analysis, and core-periphery structure to understand the developmental status of the cooperative network of clinical research publications among China's "Double First-Class" construction medical universities.
    Results: The cooperation among China's "Double First-Class" construction universities showed certain regional distribution characteristics, and they showed closer cooperation in publishing papers in international journals than in domestic ones. The overall density of the domestic-journal research collaboration network of the universities was 0.4229, mainly centered on Beijing University of Traditional Chinese Medicine and Shanghai University of Traditional Chinese Medicine. In contrast, the overall density of international-journal research collaboration network was 0.9052, mainly centered on Peking University, Central South University, and Zhengzhou University, with large differences in subgroup density and low integration.
    Conclusions: To promote the development of clinical research, it is necessary to improve the construction of the interuniversity clinical research collaboration system, build a national clinical research network with a multilevel structure and sophisticated functions, and expand resource sharing as well as collaborative innovation capacity.
    Sprache Englisch
    Erscheinungsdatum 2022-03-30
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-516
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Advances in polysaccharides of natural source of anti-diabetes effect and mechanism.

    Yang, Mao-Hui / Yang, Yan / Zhou, Xin / Chen, Hua-Guo

    Molecular biology reports

    2024  Band 51, Heft 1, Seite(n) 101

    Abstract: Purpose: Diabetes is a chronic disease in metabolic disorder, and the pathology is characterized by insulin resistance and insulin secretion disorder in blood. In current, many studies have revealed that polysaccharides extracted from natural sources ... ...

    Abstract Purpose: Diabetes is a chronic disease in metabolic disorder, and the pathology is characterized by insulin resistance and insulin secretion disorder in blood. In current, many studies have revealed that polysaccharides extracted from natural sources with significant anti-diabetic effects. Natural polysaccharides can ameliorate diabetes through different action mechanisms. All these polysaccharides are expected to have an important role in the clinic.
    Methods: Existing polysaccharides for the treatment of diabetes are reviewed, and the mechanism of polysaccharides in the treatment of diabetes and its structural characteristics are described in detail.
    Results: This article introduced the natural polysaccharide through different mechanisms of action in the treatment of diabetes, including oxidative stress, apoptosis, inflammatory response and regulation of intestinal bacteria. Natural polysaccharides can treat of diabetes by regulating signaling pathways is also a research hotspot. In addition, the structural characteristics of polysaccharides were explored. There are some structure-activity relationships between natural polysaccharides and the treatment of diabetes.
    Mesh-Begriff(e) Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/chemistry ; Diabetes Mellitus/drug therapy ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Polysaccharides/chemistry ; Oxidative Stress ; Insulin Resistance
    Chemische Substanzen Hypoglycemic Agents ; Polysaccharides
    Sprache Englisch
    Erscheinungsdatum 2024-01-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-09081-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Lipidomic investigation of the protective effects of Polygonum perfoliatum against chemical liver injury in mice.

    Peng, Lei / Chen, Hua-Guo / Zhou, Xin

    Journal of integrative medicine

    2023  Band 21, Heft 3, Seite(n) 289–301

    Abstract: Objective: Recent investigations have demonstrated that Polygonum perfoliatum L. can protect against chemical liver injury, but the mechanism behind its efficacy is still unclear. Therefore, we studied the pharmacological mechanism at work in P. ... ...

    Abstract Objective: Recent investigations have demonstrated that Polygonum perfoliatum L. can protect against chemical liver injury, but the mechanism behind its efficacy is still unclear. Therefore, we studied the pharmacological mechanism at work in P. perfoliatum protection against chemical liver injury.
    Methods: To evaluate the activity of P. perfoliatum against chemical liver injury, levels of alanine transaminase, lactic dehydrogenase, aspartate transaminase, superoxide dismutase, glutathione peroxidase and malondialdehyde were measured, alongside histological assessments of the liver, heart and kidney tissue. A nontargeted lipidomics strategy based on ultra-performance liquid chromatography quadrupole-orbitrap high-resolution mass spectrometry method was used to obtain the lipid profiles of mice with chemical liver injury and following treatment with P. perfoliatum; these profiles were used to understand the possible mechanisms behind P. perfoliatum's protective activity.
    Results: Lipidomic studies indicated that P. perfoliatum protected against chemical liver injury, and the results were consistent between histological and physiological analyses. By comparing the profiles of liver lipids in model and control mice, we found that the levels of 89 lipids were significantly changed. In animals receiving P. perfoliatum treatment, the levels of 8 lipids were significantly improved, relative to the model animals. The results showed that P. perfoliatum extract could effectively reverse the chemical liver injury and significantly improve the abnormal liver lipid metabolism of mice with chemical liver injury, especially glycerophospholipid metabolism.
    Conclusion: Regulation of enzyme activity related to the glycerophospholipid metabolism pathway may be involved in the mechanism of P. perfoliatum's protection against liver injury. Please cite this article as: Peng L, Chen HG, Zhou X. Lipidomic investigation of the protective effects of Polygonum perfoliatum against chemical liver injury in mice. J Integr Med. 2023; 21(3): 289-301.
    Mesh-Begriff(e) Animals ; Mice ; Polygonum/chemistry ; Lipidomics ; Liver ; Lipids/pharmacology ; Glycerophospholipids/metabolism ; Glycerophospholipids/pharmacology ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/prevention & control ; Chemical and Drug Induced Liver Injury/metabolism
    Chemische Substanzen Lipids ; Glycerophospholipids
    Sprache Englisch
    Erscheinungsdatum 2023-03-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2023.03.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Frustrated Lewis Pairs in Heterogeneous Catalysis

    Qiang Wan / Sen Lin / Hua Guo

    Molecules, Vol 27, Iss 3734, p

    Theoretical Insights

    2022  Band 3734

    Abstract: Frustrated Lewis pair (FLP) catalysts have attracted much recent interest because of their exceptional ability to activate small molecules in homogeneous catalysis. In the past ten years, this unique catalysis concept has been extended to heterogeneous ... ...

    Abstract Frustrated Lewis pair (FLP) catalysts have attracted much recent interest because of their exceptional ability to activate small molecules in homogeneous catalysis. In the past ten years, this unique catalysis concept has been extended to heterogeneous catalysis, with much success. Herein, we review the recent theoretical advances in understanding FLP-based heterogeneous catalysis in several applications, including metal oxides, functionalized surfaces, and two-dimensional materials. A better understanding of the details of the catalytic mechanism can help in the experimental design of novel heterogeneous FLP catalysts.
    Schlagwörter heterogeneous catalysis ; frustrated Lewis pairs ; hydrogen dissociation ; alkynes hydrogenation ; density functional theory ; Organic chemistry ; QD241-441
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Cryptanalysis of a white‐box SM4 implementation based on collision attack

    Rusi Wang / Hua Guo / Jiqiang Lu / Jianwei Liu

    IET Information Security, Vol 16, Iss 1, Pp 18-

    2022  Band 27

    Abstract: Abstract White‐box cryptography is to primarily protect the key of a cipher from being extracted in a white‐box scenario, where an adversary has full access to the execution environment of software implementation. Since the introduction of white‐box ... ...

    Abstract Abstract White‐box cryptography is to primarily protect the key of a cipher from being extracted in a white‐box scenario, where an adversary has full access to the execution environment of software implementation. Since the introduction of white‐box cryptography, a number of white‐box implementations of the Chinese SM4 block cipher standard have been proposed, and all of them have been attacked based on Billet et al.’s attack. In this study, we show that collision‐based attack can work more efficiently on Shi et al.’s white‐box SM4 implementation than the previously published attacks, by devising an attack with a time complexity of 223, significantly reducing the previously known time complexity of 249 to a very practical level. Our attack can also be similarly applied to some other white‐box SM4 implementations.
    Schlagwörter computational complexity ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
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  9. Artikel ; Online: Dynamics Analysis of a Stochastic Hybrid Logistic Model with Delay and Two-Pulse Perturbations

    Haokun Qi / Hua Guo

    Complexity, Vol

    2020  Band 2020

    Abstract: In this paper, we propose and discuss a stochastic logistic model with delay, Markovian switching, Lévy jump, and two-pulse perturbations. First, sufficient criteria for extinction, nonpersistence in the mean, weak persistence, persistence in the mean, ... ...

    Abstract In this paper, we propose and discuss a stochastic logistic model with delay, Markovian switching, Lévy jump, and two-pulse perturbations. First, sufficient criteria for extinction, nonpersistence in the mean, weak persistence, persistence in the mean, and stochastic permanence of the solution are gained. Then, we investigate the lower (upper) growth rate of the solutions. At last, we make use of Matlab to illustrate the main results and give an explanation of biological implications: the large stochastic disturbances are disadvantageous for the persistence of the population; excessive impulsive harvesting or toxin input can lead to extinction of the population.
    Schlagwörter Electronic computers. Computer science ; QA75.5-76.95
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Hindawi-Wiley
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Applications of Geophysical Logs to Coal Mining—Some Illustrative Examples

    Binzhong Zhou / Hua Guo

    Resources, Vol 9, Iss 2, p

    2020  Band 11

    Abstract: Geophysical logs can be used not only for qualitative interpretation such as strata correlation but also for geotechnical assessment through quantitative data analysis. In an emerging digital mining age, such a use of geophysical logs helps to establish ... ...

    Abstract Geophysical logs can be used not only for qualitative interpretation such as strata correlation but also for geotechnical assessment through quantitative data analysis. In an emerging digital mining age, such a use of geophysical logs helps to establish reliable geological and geotechnical models, which reduces safety and financial risks due to geological and geotechnical uncertainty for new and existing coal mining projects. This paper presents some examples of geological and geotechnical characterizations from geophysical logs at various coal mines in Australia and India. The applications include rock strength and coal quality estimations, automated lithological/geotechnical interpretation and geophysical strata rating, all based on geophysical logs. These derived parameters could provide input to modelling, control, even ‘digital twin’ generation in a form of geological and geotechnical models as part of the future digital mining. The outcomes can be visualized in 3D space and used for identifying the key geotechnical strata units that are responsible for caving behaviors during longwall mining. This could assist site geologists and planning and production engineers predict and manage mining conditions on an ongoing basis. Both conventional logs such as density, natural gamma and sonic and less common logging data, such as full waveform sonic, televiewer and SIROLOG spectrometric natural gamma logging data are examined for their potential applications. The geotechnical strata classification and rock strengths predicted from the geophysical logs match the laboratory tests, drill core geotechnical strata classification, core photos and the mining condition/behavior observed. These illustrate the usefulness and effectiveness of using geophysical logs for geological and geotechnical characterizations.
    Schlagwörter geophysical log ; geotechnical characterization ; rock strength ; coal quality ; Science ; Q
    Thema/Rubrik (Code) 550
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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