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  1. Artikel ; Online: Highlights of the British Cardiovascular Society's Future of Cardiology Working Group paper.

    Hudson, Sarah

    Heart (British Cardiac Society)

    2020  Band 107, Heft 3, Seite(n) 254–256

    Mesh-Begriff(e) COVID-19 ; Cardiology/trends ; Delivery of Health Care ; Forecasting ; Heart Diseases/diagnosis ; Heart Diseases/therapy ; Humans ; United Kingdom
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2020-318250
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  2. Artikel ; Online: Symmetry.

    Hudson, Sarah

    Families, systems & health : the journal of collaborative family healthcare

    2019  Band 36, Heft 4, Seite(n) 549

    Abstract: In family medicine, there is a symmetry of physicians' involvement in patients' lives, shepherding families through life transitions in the beginning, middle, and end. As a teaching physician, the author bears witness to another "birth" in the ... ...

    Abstract In family medicine, there is a symmetry of physicians' involvement in patients' lives, shepherding families through life transitions in the beginning, middle, and end. As a teaching physician, the author bears witness to another "birth" in the development of resident physicians. This poem on symmetry was born on a particularly poignant day: helping a new intern "catch" his first baby in the morning, then gathering with the author's own family in the evening for the passing of her grandmother. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
    Sprache Englisch
    Erscheinungsdatum 2019-01-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1326859-4
    ISSN 1939-0602 ; 1091-7527 ; 0736-1718
    ISSN (online) 1939-0602
    ISSN 1091-7527 ; 0736-1718
    DOI 10.1037/fsh0000381
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  3. Artikel ; Online: 'Never be mediocre': a conversation with Professor Nick Curzen, President-Elect of the British Cardiovascular Intervention Society.

    Hudson, Sarah

    Heart (British Cardiac Society)

    2019  Band 105, Heft 21, Seite(n) 1680–1681

    Mesh-Begriff(e) Attitude of Health Personnel ; Cardiologists/education ; Cardiologists/psychology ; Cardiology/education ; Career Choice ; Education, Medical, Graduate ; Humans ; Mentors ; Self Concept ; Work-Life Balance
    Sprache Englisch
    Erscheinungsdatum 2019-07-05
    Erscheinungsland England
    Dokumenttyp Interview ; Portrait
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2019-315567
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  4. Artikel ; Online: On the ethics of removing Entonox® from labour ward: beyond carbon dioxide equivalents and seeking justice for patients and the planet.

    Hudson, Sarah / Muspratt-Tucker, Nadia / Kudsk-Iversen, Søren

    Anaesthesia

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-12
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.16296
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  5. Artikel ; Online: Pre-formulation of an additive combination of two antimicrobial agents, clofazimine and nisin A, to boost antimicrobial activity.

    Naranjo, Mateo Flores / Kumar, Ajay / Ratrey, Poonam / Hudson, Sarah P

    Journal of materials chemistry. B

    2024  Band 12, Heft 6, Seite(n) 1558–1568

    Abstract: According to the World Health Organization, antimicrobial resistance is one of the top ten issues that pose a major threat to humanity. The lack of investment by the pharmaceutical industry has meant fewer novel antimicrobial agents are in development, ... ...

    Abstract According to the World Health Organization, antimicrobial resistance is one of the top ten issues that pose a major threat to humanity. The lack of investment by the pharmaceutical industry has meant fewer novel antimicrobial agents are in development, exacerbating the problem. Emerging drug design strategies are exploring the repurposing of existing drugs and the utilization of novel drug candidates, like antimicrobial peptides, to combat drug resistance. This proactive approach is crucial in fighting global health threats. In this study, an additive combination of a repurposed anti-leprosy drug, clofazimine, and an antimicrobial peptide, nisin A, are preformulated using liquid antisolvent precipitation to generate a stable amorphous, ionized nanoparticle system to boost antimicrobial activity. The nanotechnology aims to improve the physicochemical properties of the inherently poorly water-soluble clofazimine molecules while also harnessing the previously unreported additive effect of clofazimine and nisin A. The approach transformed clofazimine into a more water-soluble salt, yielding amorphous nanoparticles stabilized by the antimicrobial peptide; and combined the two drugs into a more soluble and more active formulation. Blending pre-formulation strategies like amorphization, salt formation, and nanosizing to improve the inherent low aqueous solubility of drugs can open many new possibilities for the design of new antimicrobial agents. This fusion of pre-formulation technologies in combination with the multi-hurdle approach of selecting drugs with different effects on microbes could be key in the design platform of new antibiotics in the fight against antimicrobial resistance.
    Mesh-Begriff(e) Clofazimine/chemistry ; Anti-Infective Agents ; Antimicrobial Peptides ; Water ; Nisin
    Chemische Substanzen nisin A (EN8XKG133D) ; Clofazimine (D959AE5USF) ; Anti-Infective Agents ; Antimicrobial Peptides ; Water (059QF0KO0R) ; Nisin (1414-45-5)
    Sprache Englisch
    Erscheinungsdatum 2024-02-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb01800h
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  6. Artikel: Impact of Additives on Drug Particles during Liquid Antisolvent Crystallization and Subsequent Freeze-Drying.

    Ghosh, Peuli / Rasmuson, Ake / Hudson, Sarah P

    Organic process research & development

    2023  Band 27, Heft 11, Seite(n) 2020–2034

    Abstract: The impact of single or combinations of additives on the generation of nanosuspensions of two poorly water-soluble active pharmaceutical ingredients (APIs), fenofibrate (FF) and dalcetrapib (DCP), and their isolation to the dry state via antisolvent (AS) ...

    Abstract The impact of single or combinations of additives on the generation of nanosuspensions of two poorly water-soluble active pharmaceutical ingredients (APIs), fenofibrate (FF) and dalcetrapib (DCP), and their isolation to the dry state via antisolvent (AS) crystallization followed by freeze-drying was explored in this work. Combinations of polymeric and surfactant additives such as poly(vinyl alcohol) or hydroxypropyl methyl cellulose and sodium docusate were required to stabilize nanoparticles (∼200-300 nm) of both APIs in suspension before isolation to dryness. For both FF and DCP, multiple additives generated the narrowest, most-stable particle size distribution, with the smallest particles in suspension, compared with using a single additive. An industrially recognized freeze-drying process was used for the isolation of these nanoparticles to dryness. When processed by the liquid AS crystallization followed by freeze-drying in the presence of multiple additives, a purer monomorphic powder for FF resulted than when processed in the absence of any additive or in the presence of a single additive. It was noted that all nanoparticles freeze-dried in the presence of additives had a flat, flaky habit resulting in large surface areas. Agglomeration occurred during freeze-drying, resulting in micron-size particles. However, after freeze-drying, powders produced with single or multiple additives showed similar dissolution profiles, irrespective of aging time before drying, thus attenuating the advantage of multiple additives in terms of size observed before the freeze-drying process.
    Sprache Englisch
    Erscheinungsdatum 2023-10-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1083-6160
    ISSN 1083-6160
    DOI 10.1021/acs.oprd.3c00204
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  7. Artikel ; Online: C5a peptidase (ScpA) activity towards human type II and type III interferons.

    Duarte, Francisco / Teçza, Malgorzata / Gedi, Vinayakumar / McGourty, Kieran / Hudson, Sarah P

    Cytokine

    2024  Band 180, Seite(n) 156652

    Abstract: C5a peptidase, also known as ScpA, is a surface associated serine protease derived from Streptococcus pyogenes and has been described as an important factor in streptococcus virulence, capable of cleaving complement components C5a, C3 and C3a. Although ... ...

    Abstract C5a peptidase, also known as ScpA, is a surface associated serine protease derived from Streptococcus pyogenes and has been described as an important factor in streptococcus virulence, capable of cleaving complement components C5a, C3 and C3a. Although the interactions of ScpA with complement components is well studied, extensive screening of ScpA activity against other pro-inflammatory cytokines is lacking. Here, ScpA's ability to cleave human pro-inflammatory cytokines was tested, revealing its ability to cleave human IFNγ, IFNλ1, IFNλ2, C5, IL-37 but with significantly reduced activities. The functional consequence of ScpA's cleavage of IFNγ in its signalling through the Jak-Stat pathway has also been evaluated in an in vitro RPE1 cell model. These newly identified targets for ScpA highlight the complexity of streptococcus infections and indeed, the potential for ScpA to have a therapeutic role in the progression of inflammatory diseases involving these cytokines.
    Sprache Englisch
    Erscheinungsdatum 2024-05-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2024.156652
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  8. Artikel ; Online: Synergistic antimicrobial interactions of nisin A with biopolymers and solubilising agents for oral drug delivery.

    Flynn, James / Ryan, Aoibhín / Hudson, Sarah P

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2022  Band 171, Seite(n) 29–38

    Abstract: In order to develop bacteriocins, like the lantibiotic nisin A, into effective alternatives to existing antibiotics, their biophysical and physicochemical properties must first be assessed, from solubility, to susceptibility and absorption. It has been ... ...

    Abstract In order to develop bacteriocins, like the lantibiotic nisin A, into effective alternatives to existing antibiotics, their biophysical and physicochemical properties must first be assessed, from solubility, to susceptibility and absorption. It has been well established that formulation strategies at early drug development stages can be crucial for successful outcomes during preclinical and clinical phases of development, particularly for molecules with challenging physicochemical properties. This work elucidates the physicochemical challenges of nisin A in terms of its susceptibility to digestive enzymes like pepsin, pancreatin and proteinase K and its poor solubility at physiological pHs. Low solution concentrations, below the minimum inhibitory concentration against Staphylococcus aureus, were obtained in phosphate buffered saline (PBS, pH 7.4) and in fasted state simulated intestinal fluid (FaSSIF, pH 6.5), while higher solubilities at more acidic pH's such as in a KCl/HCl buffer (pH 2) and in fasted state simulated gastric fluid (FaSSGF, pH 1.6) are observed. Tween® 80 (0.01% v/v) significantly increased the solution concentration of nisin A in PBS (pH 7.4, 24 hr). Pancreatin doubled nisin A's solution concentration at pH 7.4 (PBS) but reduced its' inhibitory activity to ∼ 20%, and pepsin almost completely degraded nisin (after 24 hr), but retained activity at biologically relevant exposure times (∼15 min). Harnessing synergism between nisin A and either glycol chitosan or ε-poly lysine, combined with the solubilizing effect of Tween®, increased the antimicrobial activity of nisin A six fold in an in vitro oral administration model.
    Mesh-Begriff(e) Administration, Oral ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Biopolymers ; Drug Delivery Systems ; Drug Synergism ; Humans ; Microbial Sensitivity Tests ; Nisin/administration & dosage ; Nisin/chemistry ; Nisin/pharmacology ; Staphylococcus aureus/drug effects
    Chemische Substanzen Anti-Bacterial Agents ; Biopolymers ; Nisin (1414-45-5)
    Sprache Englisch
    Erscheinungsdatum 2022-01-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2021.12.010
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  9. Artikel ; Online: What is 'normal' left ventricular ejection fraction?

    Hudson, Sarah / Pettit, Stephen

    Heart (British Cardiac Society)

    2020  Band 106, Heft 18, Seite(n) 1445–1446

    Mesh-Begriff(e) Clinical Decision-Making ; Echocardiography ; Humans ; Predictive Value of Tests ; Prognosis ; Reference Values ; Reproducibility of Results ; Stroke Volume ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy ; Ventricular Function, Left
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2020-317604
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  10. Artikel ; Online: The impact of varying dextran oxidation levels on the inhibitory activity of a bacteriocin loaded injectable hydrogel.

    Flynn, James / Culebras, Mario / Collins, Maurice N / Hudson, Sarah P

    Drug delivery and translational research

    2022  Band 13, Heft 1, Seite(n) 308–319

    Abstract: In the design of injectable antimicrobial dextran-alginate hydrogels, the impact of dextran oxidation and its subsequent changes in molecular weight and the incorporation of glycol chitosan on (i) gel mechanical strength and (ii) the inhibitory profile ... ...

    Abstract In the design of injectable antimicrobial dextran-alginate hydrogels, the impact of dextran oxidation and its subsequent changes in molecular weight and the incorporation of glycol chitosan on (i) gel mechanical strength and (ii) the inhibitory profile of an encapsulated bacteriocin, nisin A, are explored. As the degree of oxidation increases, the weight average molecular mass of the dextran decreases, resulting in a reduction in elastic modulus of the gels made. Upon encapsulation of the bacteriocin nisin into the gels, varying the dextran mass/oxidation level allowed the antimicrobial activity against S. aureus to be controlled. Gels made with a higher molecular weight (less oxidised) dextran show a higher initial degree of inhibition while those made with a lower molecular weight (more oxidised) dextran exhibit a more sustained inhibition. Incorporating glycol chitosan into gels composed of dextran with higher masses significantly increased their storage modulus and the gels' initial degree of inhibition.
    Mesh-Begriff(e) Hydrogels ; Bacteriocins ; Dextrans ; Staphylococcus aureus ; Anti-Infective Agents
    Chemische Substanzen Hydrogels ; Bacteriocins ; Dextrans ; Anti-Infective Agents
    Sprache Englisch
    Erscheinungsdatum 2022-07-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-022-01201-x
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