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  1. Artikel ; Online: In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH

    Hussein, Dania

    International journal of molecular sciences

    2023  Band 24, Heft 2

    Abstract: The GTP cyclohydrolase 1 enzyme (GTPCH1) is the rate-limiting enzyme of the tetrahydrobiopterin ( ... ...

    Abstract The GTP cyclohydrolase 1 enzyme (GTPCH1) is the rate-limiting enzyme of the tetrahydrobiopterin (BH
    Mesh-Begriff(e) Humans ; GTP Cyclohydrolase/genetics ; GTP Cyclohydrolase/chemistry ; Biopterins/pharmacology ; Drug Repositioning ; Molecular Docking Simulation ; Neuralgia/metabolism ; Nitric Oxide/metabolism
    Chemische Substanzen GTP Cyclohydrolase (EC 3.5.4.16) ; Biopterins ; Nitric Oxide (31C4KY9ESH)
    Sprache Englisch
    Erscheinungsdatum 2023-01-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021210
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Simultaneous determination of bisphenol A and its analogues in foodstuff using UPLC-MS/MS and assessment of their health risk in adult population

    Shaaban, Heba / Mostafa, Ahmed / Alqarni, Abdulmalik M. / Almohamed, Yasmeen / Abualrahi, Duaa / Hussein, Dania / Alghamdi, Meshal

    Journal of food composition and analysis. 2022 July, v. 110

    2022  

    Abstract: Replacing bisphenol A with its analogues may represent a risk to human health because of their potential synergic effects. In this study, a fast, sensitive and reliable UPLC-MS/MS method for the identification and quantification of bisphenol A, bisphenol ...

    Abstract Replacing bisphenol A with its analogues may represent a risk to human health because of their potential synergic effects. In this study, a fast, sensitive and reliable UPLC-MS/MS method for the identification and quantification of bisphenol A, bisphenol F, bisphenol S, D8 and pergafast in foodstuff was developed and validated. Sample preparation and clean up were carried out using ultrasonic extraction followed by solid-phase extraction on Oasis HLB cartridges. The developed method was successfully applied for simultaneous determination of the target analytes in 140 food samples from various categories (including: vegetables, dairy products, seafood products, condiments, beverages, oils & fats and others). The recovery ranged from 80.3% to 103.8% with relative standard deviations not higher than 11.5%. Limits of detection were within the range of 0.003–0.015 μg kg⁻¹ under the optimized conditions. Bisphenol A was found in the majority of food samples (83%) with the highest concentration of 110 µg kg⁻¹. Canned food contained higher concentrations of total bisphenols (23.8 µg kg⁻¹) compared to food samples packed in plastic containers (7.68 µg kg⁻¹), paper (3.53 µg kg⁻¹) or glass (1.14 µg kg⁻¹). The estimated daily intake for the detected bisphenols was also calculated (286.7 and 307.8 ng kg⁻¹ BW day⁻¹) for male and female adults, respectively. The dietary exposure to total bisphenols through foodstuffs investigated in this study were found to be higher than the recently updated tolerable daily intake value of BPA (0.04 ng kg⁻¹ BW day⁻¹). Also, the calculated hazard index was found to be higher than 1, indicating that the exposure to the detected bisphenols is more likely to cause risk to consumers through the dietary intake. To the best of our knowledge, this is the first report estimating the health risk associated with dietary exposure to bisphenol A and its analogues in Saudi Arabia.
    Schlagwörter acceptable daily intake ; adults ; average daily intake ; bisphenol A ; bisphenol F ; bisphenol S ; canned foods ; chemical species ; dietary exposure ; females ; food composition ; food intake ; glass ; human health ; males ; paper ; risk ; seafoods ; solid phase extraction ; ultrasonics ; Saudi Arabia
    Sprache Englisch
    Erscheinungsverlauf 2022-07
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 743572-1
    ISSN 0889-1575 ; 1096-0481
    ISSN 0889-1575 ; 1096-0481
    DOI 10.1016/j.jfca.2022.104549
    Datenquelle NAL Katalog (AGRICOLA)

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    Z 4776: Hefte anzeigen

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  3. Artikel: The Association between Self-Care Activities and Depression in Adult Patients with Type 2 Diabetes in Saudi Arabia: A Cross-Sectional Web-Based Survey Study.

    Kurdi, Sawsan M / Alamer, Ahmad / Albaggal, Aya / Alsuwaiket, Marwa / Alotaibi, Fawaz M / Asiri, Ibrahim M / Alshayban, Dhfer M / Alsultan, Mohammed M / Alshehail, Bashayer / Almalki, Bassem A / Hussein, Dania / Alotaibi, Mansour M / Alfayez, Osamah M

    Journal of clinical medicine

    2024  Band 13, Heft 2

    Abstract: This study examined the level of adherence to self-care behaviors among individuals with type 2 diabetes in Saudi Arabia and its connection with depression and demographic factors. A cross-sectional survey was conducted among diabetes patients using the ... ...

    Abstract This study examined the level of adherence to self-care behaviors among individuals with type 2 diabetes in Saudi Arabia and its connection with depression and demographic factors. A cross-sectional survey was conducted among diabetes patients using the Patient Health Questionnaire (PHQ-9) to measure depression and the Summary of Diabetes Self-Care Activities (SDSCA) to evaluate diabetes self-care activities. Among the 252 participants who completed the survey, 43.2% were older than 55 and 59% were men. The ordinal regression model showed an association between the PHQ-9 and SDSCA scores with an OR of 0.83 (95% CI: 0.71 to 0.96,
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020419
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Sulfadiazine Exerts Potential Anticancer Effect in HepG2 and MCF7 Cells by Inhibiting TNFα, IL1b, COX-1, COX-2, 5-LOX Gene Expression: Evidence from In Vitro and Computational Studies.

    Gomaa, Mohamed / Gad, Wael / Hussein, Dania / Pottoo, Faheem Hyder / Tawfeeq, Nada / Alturki, Mansour / Alfahad, Dhay / Alanazi, Razan / Salama, Ismail / Aziz, Mostafa / Zahra, Aboelnasr / Hanafy, Abeer

    Pharmaceuticals (Basel, Switzerland)

    2024  Band 17, Heft 2

    Abstract: Drug repurposing is a promising approach that has the potential to revolutionize the drug discovery and development process. By leveraging existing drugs, we can bring new treatments to patients more quickly and affordably. Anti-inflammatory drugs have ... ...

    Abstract Drug repurposing is a promising approach that has the potential to revolutionize the drug discovery and development process. By leveraging existing drugs, we can bring new treatments to patients more quickly and affordably. Anti-inflammatory drugs have been shown to target multiple pathways involved in cancer development and progression. This suggests that they may be more effective in treating cancer than drugs that target a single pathway. Cell viability was measured using the MTT assay. The expression of genes related to inflammation (TNFa, IL1b, COX-1, COX-2, and 5-LOX) was measured in HepG2, MCF7, and THLE-2 cells using qPCR. The levels of TNFα, IL1b, COX-1, COX-2, and 5-LOX were also measured in these cells using an ELISA kit. An enzyme binding assay revealed that sulfadiazine expressed weaker inhibitory activity against COX-2 (IC
    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17020189
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The regulation of vascular tetrahydrobiopterin bioavailability.

    Starr, Anna / Hussein, Dania / Nandi, Manasi

    Vascular pharmacology

    2013  Band 58, Heft 3, Seite(n) 219–230

    Abstract: 6R l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for several enzymes including phenylalanine hydroxylase and the nitric oxide synthases (NOS). Oral supplementation of BH4 has been successfully employed to treat subsets of patients ... ...

    Abstract 6R l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for several enzymes including phenylalanine hydroxylase and the nitric oxide synthases (NOS). Oral supplementation of BH4 has been successfully employed to treat subsets of patients with hyperphenylalaninaemia. More recently, research efforts have focussed on understanding whether BH4 supplementation may also be efficacious in cardiovascular disorders that are underpinned by reduced nitric oxide bioavailability. Whilst numerous preclinical and clinical studies have demonstrated a positive association between enhanced BH4 and vascular function, the efficacy of orally administered BH4 in human cardiovascular disease remains unclear. Furthermore, interventions that limit BH4 bioavailability may provide benefit in diseases where nitric oxide over production contributes to pathology. This review describes the pathways involved in BH4 bio-regulation and discusses other endogenous mechanisms that could be harnessed therapeutically to manipulate vascular BH4 levels.
    Mesh-Begriff(e) Administration, Oral ; Animals ; Biological Availability ; Biopterins/administration & dosage ; Biopterins/analogs & derivatives ; Biopterins/metabolism ; Biopterins/pharmacology ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/physiopathology ; Humans ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Phenylalanine Hydroxylase/metabolism ; Phenylketonurias/drug therapy ; Phenylketonurias/physiopathology
    Chemische Substanzen Biopterins ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Phenylalanine Hydroxylase (EC 1.14.16.1) ; sapropterin (EGX657432I)
    Sprache Englisch
    Erscheinungsdatum 2013-04-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2082846-9
    ISSN 1879-3649 ; 1537-1891 ; 1879-3649
    ISSN (online) 1879-3649 ; 1537-1891
    ISSN 1879-3649
    DOI 10.1016/j.vph.2012.08.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 591: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Artikel ; Online: l-Phenylalanine Restores Vascular Function in Spontaneously Hypertensive Rats Through Activation of the GCH1-GFRP Complex.

    Heikal, Lamia / Starr, Anna / Hussein, Dania / Prieto-Lloret, Jesus / Aaronson, Phil / Dailey, Lea Ann / Nandi, Manasi

    JACC. Basic to translational science

    2018  Band 3, Heft 3, Seite(n) 366–377

    Abstract: Reduced nitric oxide (NO) bioavailability correlates with impaired cardiovascular function. NO is extremely labile and has been challenging to develop as a therapeutic agent. However, NO bioavailability could be enhanced by pharmacologically targeting ... ...

    Abstract Reduced nitric oxide (NO) bioavailability correlates with impaired cardiovascular function. NO is extremely labile and has been challenging to develop as a therapeutic agent. However, NO bioavailability could be enhanced by pharmacologically targeting endogenous NO regulatory pathways. Tetrahydrobiopterin, an essential cofactor for NO production, is synthesized by GTP cyclohydrolase-1 (GCH1), which complexes with GCH1 feedback regulatory protein (GFRP). The dietary amino acid l-phenylalanine activates this complex, elevating vascular BH
    Sprache Englisch
    Erscheinungsdatum 2018-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2018.01.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations.

    Lee, Jiwon / Paparoditis, Philipp / Horton, Andrew P / Frühwirth, Alexander / McDaniel, Jonathan R / Jung, Jiwon / Boutz, Daniel R / Hussein, Dania A / Tanno, Yuri / Pappas, Leontios / Ippolito, Gregory C / Corti, Davide / Lanzavecchia, Antonio / Georgiou, George

    Cell host & microbe

    2019  Band 25, Heft 3, Seite(n) 367–376.e5

    Abstract: Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact antibody responses is essential for vaccine development. Given the recent prevalence of influenza H1N1 ...

    Abstract Humans are repeatedly exposed to influenza virus via infections and vaccinations. Understanding how multiple exposures and pre-existing immunity impact antibody responses is essential for vaccine development. Given the recent prevalence of influenza H1N1 A/California/7/2009 (CA09), we examined the clonal composition and dynamics of CA09 hemagglutinin (HA)-reactive IgG repertoire over 5 years in a donor with multiple influenza exposures. The anti-CA09 HA polyclonal response in this donor comprised 24 persistent antibody clonotypes, accounting for 72.6% ± 10.0% of the anti-CA09 HA repertoire over 5 years. These persistent antibodies displayed higher somatic hypermutation relative to transient serum antibodies detected at one time point. Additionally, persistent antibodies predominantly demonstrated cross-reactivity and potent neutralization toward a phylogenetically distant H5N1 A/Vietnam/1203/2004 (VT04) strain, a feature correlated with HA stem recognition. This analysis reveals how "serological imprinting" impacts responses to influenza and suggests that once elicited, cross-reactive antibodies targeting the HA stem can persist for years.
    Mesh-Begriff(e) Antibodies, Viral/blood ; Female ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Humans ; Immunity, Humoral ; Immunoglobulin G/blood ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Middle Aged ; Orthomyxoviridae/immunology ; Serum/immunology ; Switzerland
    Chemische Substanzen Antibodies, Viral ; H1N1 virus hemagglutinin ; Hemagglutinin Glycoproteins, Influenza Virus ; Immunoglobulin G ; Influenza Vaccines
    Sprache Englisch
    Erscheinungsdatum 2019-02-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2019.01.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6578: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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