Artikel ; Online: Central precocious puberty in boys: secular trend and clinical features.
European journal of endocrinology
2024 Band 190, Heft 3, Seite(n) 211–219
Abstract: Objective: Recent studies suggest that boys enter puberty at a younger age, and the incidence of male central precocious puberty (CPP) is increasing. In this study, we explore the incidence of male CPP and identify key clinical and auxological ... ...
| Abstract | Objective: Recent studies suggest that boys enter puberty at a younger age, and the incidence of male central precocious puberty (CPP) is increasing. In this study, we explore the incidence of male CPP and identify key clinical and auxological indicators for organic CPP (OCPP). Design: A retrospective registry-based study. Methods: The medical records of 43 boys treated with CPP at the Helsinki University Hospital between 1985 and 2014 were reviewed. Clinical, auxological, and endocrine data of the CPP patients were included in the analyses. Results: Based on brain MRI, 26% of patients had OCPP. Between 2010 and 2014, the CPP incidence in boys was 0.34 per 10 000 (95% CI 0.20-0.60). Between 1990 and 2014, the male CPP incidence increased (incidence rate ratio [IRR] 1.10, P = .001). This increase was driven by rising idiopathic CPP (ICPP) incidence (IRR 1.11, 95% CI 1.05-1.19, P < .001), while OCPP incidence remained stable (P = .41). Compared with the patients with ICPP, the patients with OCPP were younger (P = .006), were shorter (P = .003), and had higher basal serum testosterone levels (P = .038). Combining 2 to 4 of these readily available clinical cues resulted in good to excellent (all, area under the curve 0.84-0.97, P < .001) overall performance, differentiating organic etiology from idiopathic. Conclusions: The estimated incidence of CPP in boys was 0.34 per 10 000, with 26% of cases associated with intracranial pathology. The increase in CPP incidence was driven by rising ICPP rates. Patients with OCPP were characterized by shorter stature, younger age, and higher basal testosterone levels, providing valuable cues for differentiation in addition to brain MRI. Utilizing multiple cues could guide diagnostic decision-making. |
|---|---|
| Mesh-Begriff(e) | Humans ; Male ; Luteinizing Hormone ; Puberty, Precocious/diagnosis ; Puberty, Precocious/epidemiology ; Follicle Stimulating Hormone ; Retrospective Studies ; Testosterone ; Gonadotropin-Releasing Hormone |
| Chemische Substanzen | Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0) ; Testosterone (3XMK78S47O) ; Gonadotropin-Releasing Hormone (33515-09-2) |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-03-27 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 1183856-5 |
| ISSN | 1479-683X ; 0804-4643 |
| ISSN (online) | 1479-683X |
| ISSN | 0804-4643 |
| DOI | 10.1093/ejendo/lvae021 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
| Uh III Zs.147: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.