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  1. Artikel ; Online: Impact of sex on outcomes after percutaneous repair of functional mitral valve regurgitation.

    Chan, Vincent / Messika-Zeitoun, David / Labinaz, Marino / Hynes, Mark / Nicholson, Donna / Dryden, Adam / Mesana, Thierry / Hibbert, Benjamin

    Journal of cardiac surgery

    2021  Band 36, Heft 6, Seite(n) 1900–1903

    Abstract: Background: The role of percutaneous repair of functional mitral regurgitation (MR) is evolving. Left ventricle remodeling is known to be different between men and women; however, outcomes following percutaneous repair of functional MR have not ... ...

    Abstract Background: The role of percutaneous repair of functional mitral regurgitation (MR) is evolving. Left ventricle remodeling is known to be different between men and women; however, outcomes following percutaneous repair of functional MR have not considered the impact of sex.
    Methods: Between 2012 and 2018, 175 patients underwent percutaneous repair of functional MR with the Mitra Clip NT/NTR (Abbott) at our institution. Patients were assessed in a dedicated clinic with a follow-up that averaged 0.7 ± 1.2 years and extended to 5.7 years.
    Results: Men had a larger body surface area than women (p < .001), and were more likely than women to have diabetes preoperatively (p = .02). There were no deaths or instances of single leaflet detachment. Immediate postprocedure MR was ≤2+ in 158 (90%) with a mean trans-mitral valve repair gradient of 3.4 ± 1.0 and 3.5 ± 2.1 mmHg, respectively for women and men (p = .8). One- and 2-year freedom from MR ≥3+ was 86.0 ± 3.5% and 77.6 ± 5.1%, respectively. After adjusting for differences between male and female patients, women were more likely to have recurrent MR ≥3+ (hazard ratio, 4.7; 95% confidence interval, 1.2-18.4; p = .03). Upon adjusted analysis, there was also no association between gender and survival (p = .2). One- and 2-year survival was 69.8 ± 4.3% and 54.3 ± 5.5%, respectively.
    Conclusion: Women are more likely to have recurrent severe MR after percutaneous repair of functional MR. The mechanism for this remains undetermined.
    Mesh-Begriff(e) Cardiac Surgical Procedures ; Female ; Humans ; Male ; Mitral Valve Insufficiency/surgery ; Proportional Hazards Models ; Retrospective Studies ; Treatment Outcome ; Ventricular Remodeling
    Sprache Englisch
    Erscheinungsdatum 2021-02-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.15445
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Computed Simulation of Transcatheter Edge-to-Edge Mitral Valve Repair - A Proof of Concept Study.

    Messika-Zeitoun, David / Mousavi, Jamal / Pourmoazen, Mohammad / Cotte, Florian / Dreyfus, Julien / Nejjari, Mohammed / Attias, David / Kloeckner, Martin / Ghostine, Said / Pierrard, Romain / Eker, Armand / Levy, Franck / Le Dolley, Yvan / Houel, Remi / Unni, Rudy R / Burwash, Ian G / Dryden, Adam / Hynes, Mark / Nicholson, Donna /
    Labinaz, Marino / Chan, Vincent / Albertini, Jean-Noel / Mesana, Thierry

    European heart journal. Cardiovascular Imaging

    2024  

    Abstract: Aims: As transcatheter mitral valve (MV) interventions are expanding and more device types and sizes become available, a tool supporting operators in preprocedural planning and the clinical decision-making process is highly desirable. We sought to ... ...

    Abstract Aims: As transcatheter mitral valve (MV) interventions are expanding and more device types and sizes become available, a tool supporting operators in preprocedural planning and the clinical decision-making process is highly desirable. We sought to develop a finite element (FE) computational simulation model to predict results of transcatheter edge-to-edge (TEER) interventions.
    Methods and results: We prospectively enrolled patients with secondary mitral regurgitation (MR) referred for a clinically indicated TEER. Three-dimensional (3D) transesophageal echocardiograms performed at the beginning of the procedure were used to perform the simulation. On the 3D dynamic model of the MV that was first obtained, we simulated the clip implantation using the same clip(s) type, size, number, and implantation location that was used during the intervention. The 3D model of the MV obtained after simulation of the clip implantation was compared to the clinical results obtained at the end of the intervention. We analyzed the degree and location of residual MR and the shape and area of the diastolic mitral valve area. We performed computational simulation on 5 patients. Overall, the simulated models predicted well the degree and location of the residual regurgitant orifice(s) but tended to underestimate the diastolic mitral orifice area.
    Conclusions: In this proof-of-concept study, we present preliminary results on our algorithm simulating clip implantation in 5 patients with functional MR. We show promising results regarding the feasibility and accuracy in terms of predicting residual MR and the need to improve the estimation of the diastolic mitral valve area.
    Sprache Englisch
    Erscheinungsdatum 2024-05-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeae137
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  3. Artikel ; Online: Mitral valve repair in acquired dextrocardia.

    Elmistekawy, Elsayed / Chan, Vincent / Hynes, Mark / Mesana, Thierry

    Asian cardiovascular & thoracic annals

    2015  Band 23, Heft 8, Seite(n) 979–981

    Abstract: Surgical correction of valvular heart disease in patients with dextrocardia is extremely rare. We report a surgical case of mitral valve repair in a patient with acquired dextrocardia. Successful mitral valve repair was performed through a right lateral ... ...

    Abstract Surgical correction of valvular heart disease in patients with dextrocardia is extremely rare. We report a surgical case of mitral valve repair in a patient with acquired dextrocardia. Successful mitral valve repair was performed through a right lateral thoracotomy. We describe our surgical strategy and summarize the literature.
    Mesh-Begriff(e) Adult ; Dextrocardia/complications ; Dextrocardia/diagnosis ; Female ; Heart Valve Prosthesis Implantation ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Mitral Valve Annuloplasty ; Mitral Valve Insufficiency/complications ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Tomography, X-Ray Computed ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2015-10
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/0218492314530975
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Transcatheter mitral valve repair for inotrope dependent cardiogenic shock - Design and rationale of the CAPITAL MINOS trial.

    Parlow, Simon / Di Santo, Pietro / Jung, Richard G / Fam, Neil / Czarnecki, Andrew / Horlick, Eric / Abdel-Razek, Omar / Chan, Vincent / Hynes, Mark / Nicholson, Donna / Dryden, Adam / Fernando, Shannon M / Wells, George A / Bernick, Jordan / Labinaz, Marino / Mathew, Rebecca / Simard, Trevor / Hibbert, Benjamin

    American heart journal

    2022  Band 254, Seite(n) 81–87

    Abstract: Background: Functional mitral regurgitation (MR) is an important clinical consideration in patients with heart failure. Transcatheter edge-to-edge repair (TEER) has emerged as a useful therapeutic tool for patients with chronic heart failure, however ... ...

    Abstract Background: Functional mitral regurgitation (MR) is an important clinical consideration in patients with heart failure. Transcatheter edge-to-edge repair (TEER) has emerged as a useful therapeutic tool for patients with chronic heart failure, however the role of TEER in patients with cardiogenic shock (CS) and MR has not yet been studied in a randomized trial. The Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock (CAPITAL MINOS) trial was therefore designed to determine if TEER improves clinical outcomes in the CS population.
    Methods and design: The CAPITAL MINOS trial is an open-label, multi-center randomized clinical trial comparing TEER to medical therapy in patients with CS and MR. A total of 144 patients with Society for Cardiovascular Angiography and Interventions (SCAI) class C or D CS and at least 3+ MR will be randomized in a 1:1 ratio to TEER or medical therapy alone. The primary outcome will be a composite of in-hospital all-cause mortality, cardiac transplantation, implantation of durable left ventricular assist device, or discharge on palliative inotropic therapy. Patients will be followed for the duration of their index hospitalization for the primary outcome. Secondary outcomes include 6 month mortality.
    Implications: The CAPITAL MINOS trial will determine whether TEER improves outcomes in patients with CS and MR and will be an important step in optimizing treatment for this high-risk patient population.
    Sprache Englisch
    Erscheinungsdatum 2022-08-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2022.08.008
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  5. Artikel ; Online: Percutaneous Mitral Repair as Salvage Therapy in Patients With Mitral Regurgitation and Refractory Cardiogenic Shock.

    Chan, Vincent / Messika-Zeitoun, David / Labinaz, Marino / Hynes, Mark / Nicholson, Donna / Dryden, Adam / Mesana, Thierry / Hibbert, Benjamin

    Circulation. Cardiovascular interventions

    2019  Band 12, Heft 11, Seite(n) e008435

    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/instrumentation ; Cardiac Catheterization/mortality ; Female ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Heart Valve Prosthesis Implantation/mortality ; Hemodynamics ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/mortality ; Mitral Valve Insufficiency/physiopathology ; Mitral Valve Insufficiency/surgery ; Prosthesis Design ; Recovery of Function ; Salvage Therapy/adverse effects ; Salvage Therapy/instrumentation ; Salvage Therapy/mortality ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/mortality ; Shock, Cardiogenic/physiopathology ; Shock, Cardiogenic/therapy ; Time Factors ; Treatment Outcome ; Ventricular Function, Left
    Sprache Englisch
    Erscheinungsdatum 2019-11-07
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.119.008435
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: How Does Mitral Valve Repair Fail in Patients With Prolapse?-Insights From Longitudinal Echocardiographic Follow-Up.

    Chan, Vincent / Elmistekawy, Elsayed / Ruel, Marc / Hynes, Mark / Mesana, Thierry G

    The Annals of thoracic surgery

    2016  Band 102, Heft 5, Seite(n) 1459–1465

    Abstract: Background: Repair of mitral regurgitation (MR) caused by prolapse has been well validated. Although favorable early and late results after repair have been reported, few data are available that mechanistically describe how a mitral repair fails beyond ... ...

    Abstract Background: Repair of mitral regurgitation (MR) caused by prolapse has been well validated. Although favorable early and late results after repair have been reported, few data are available that mechanistically describe how a mitral repair fails beyond the mere need for mitral valve reoperation. We therefore sought to determine the modes of valve repair failure in patients who underwent surgical correction of MR caused by prolapse.
    Methods: Between 2001 and 2015, 855 patients underwent repair of MR caused by prolapse. Patients were a mean age of 63.7 ± 12.7 years, and 380 (44%) had bileaflet prolapse. The overall repair rate was 97.2%. These patients were monitored as part of a cohort initiative and underwent serial clinical and echocardiographic assessments at 1, 3 to 6, and 12 months after the operation. Beyond the first year of the MR repair, patients were assessed by echocardiography every 1 to 2 years or when clinically indicated. Clinical and echocardiographic follow-up averaged 4.3 ± 3.5 years.
    Results: Freedom from recurrent MR of 2+ or higher was 92.4% ± 1.3% at 5 years and 86.6% ± 2.4% at 10 years. Overall, recurrent MR of 2+ or higher developed in 49 patients (5.7%) at a mean of 3.1 ± 2.5 years after the repair, of whom 14 (1.6%) had recurrent MR of 3+ or 4+. Among patients with bileaflet prolapse, recurrent MR of 2+ or higher was observed in 24, of whom 9 had 3+ or 4+ MR., The development of recurrent MR of 2+ or higher was categorized as prolapse in 6 and nonprolapse in 43. Severe mitral stenosis occurred in 3 patients at 8.2 years after the MR repair. Mitral reoperation was ultimately performed in 21 patients. Patients who had recurrent MR 2+ or higher within the first year after the operation were more likely to undergo a subsequent mitral valve reoperation (incident rate ratio, 5.2 ± 2.9; p = 0.003), although no association between recurrent MR and reoperation was observed after the first year.
    Conclusions: Severe MR after repair is rare, although some may have recurrent moderate MR. Patients who required a subsequent mitral valve reoperation were most likely to have recurrent MR of 2+ or higher within the first year after the operation.
    Mesh-Begriff(e) Echocardiography/methods ; Female ; Follow-Up Studies ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnosis ; Mitral Valve Insufficiency/mortality ; Mitral Valve Insufficiency/surgery ; Ontario/epidemiology ; Reoperation ; Retrospective Studies ; Survival Rate/trends ; Time Factors ; Treatment Failure ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2016-11
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2016.08.088
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  7. Artikel: Clinical Diagnostic Tests versus Medial Branch Blocks for Adults with Persisting Cervical Zygapophyseal Joint Pain: A Systematic Review and Meta-Analysis.

    Usunier, Kendra / Hynes, Mark / Schuster, James Michael / Cornelio-Jin Suen, Annie / Sadi, Jackie / Walton, David

    Physiotherapy Canada. Physiotherapie Canada

    2018  Band 70, Heft 2, Seite(n) 179–187

    Abstract: Purpose: ...

    Abstract Purpose:
    Sprache Englisch
    Erscheinungsdatum 2018-05-14
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 639189-8
    ISSN 1708-8313 ; 0300-0508
    ISSN (online) 1708-8313
    ISSN 0300-0508
    DOI 10.3138/ptc.2016-89.mt
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  8. Artikel: Repair of quadricuspid aortic valve associated with ascending aorta dilatation.

    Elmistekawy, Elsayed M / Malas, Tarek / Hynes, Mark / Boodhwani, Munir

    The Journal of heart valve disease

    2012  Band 21, Heft 6, Seite(n) 740–742

    Abstract: Quadricuspid aortic valve is a rare congenital anomaly that may require surgical intervention because of valvular dysfunction. Rarely, it may be associated with enlargement of the ascending aorta. Here, the case is presented of a quadricuspid aortic ... ...

    Abstract Quadricuspid aortic valve is a rare congenital anomaly that may require surgical intervention because of valvular dysfunction. Rarely, it may be associated with enlargement of the ascending aorta. Here, the case is presented of a quadricuspid aortic valve-associated enlargement of the ascending aorta and functional aortic annulus dilatation in a 36-year-old patient. The patient subsequently underwent a successful aortic valve repair and replacement of the ascending aorta.
    Mesh-Begriff(e) Adult ; Aortic Aneurysm/complications ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/surgery ; Aortic Valve/abnormalities ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Blood Vessel Prosthesis Implantation ; Cardiac Valve Annuloplasty ; Dilatation, Pathologic ; Echocardiography, Transesophageal ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/surgery ; Humans ; Male ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2012-11
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1205265-6
    ISSN 2053-2644 ; 0966-8519
    ISSN (online) 2053-2644
    ISSN 0966-8519
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Mechanical valve thrombosis with dabigatran.

    Price, Joel / Hynes, Mark / Labinaz, Marino / Ruel, Marc / Boodhwani, Munir

    Journal of the American College of Cardiology

    2012  Band 60, Heft 17, Seite(n) 1710–1711

    Mesh-Begriff(e) Antithrombins/therapeutic use ; Benzimidazoles/therapeutic use ; Dabigatran ; Diagnosis, Differential ; Echocardiography, Transesophageal ; Female ; Follow-Up Studies ; Heart Diseases/diagnosis ; Heart Diseases/drug therapy ; Heart Diseases/etiology ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis/adverse effects ; Humans ; Middle Aged ; Prosthesis Failure ; Thrombosis/diagnosis ; Thrombosis/drug therapy ; Thrombosis/etiology ; beta-Alanine/analogs & derivatives ; beta-Alanine/therapeutic use
    Chemische Substanzen Antithrombins ; Benzimidazoles ; beta-Alanine (11P2JDE17B) ; Dabigatran (I0VM4M70GC)
    Sprache Englisch
    Erscheinungsdatum 2012-10-23
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2012.06.039
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  10. Artikel ; Online: Aortic root geometry in bicuspid aortic insufficiency versus stenosis: implications for valve repair.

    Al-Atassi, Talal / Hynes, Mark / Sohmer, Benjamin / Lam, Buu-Khanh / Mesana, Thierry / Boodhwani, Munir

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2014  Band 47, Heft 4, Seite(n) e151–4

    Abstract: Objectives: The contribution of aortic annular and root disease in bicuspid aortic valve (BAV) insufficiency remains unclear. We compared aortic root geometry between BAV stenosis and aortic insufficiency (AI), before and after repair.: Methods: ... ...

    Abstract Objectives: The contribution of aortic annular and root disease in bicuspid aortic valve (BAV) insufficiency remains unclear. We compared aortic root geometry between BAV stenosis and aortic insufficiency (AI), before and after repair.
    Methods: Patients presenting for surgery for BAV insufficiency (n = 58) were compared with patients with BAV stenosis (n = 58). Clinical and transoesophageal echocardiographic data were collected, including end-diastolic diameters of the ventriculo-aortic junction (VAJ), aortic root, sinotubular junction (STJ) and ascending aorta (AA).
    Results: AI patients were younger and more likely to be male compared with aortic stenosis (AS) patients. VAJ, aortic root and STJ diameters were significantly larger in AI compared with AS patients (30 ± 0.5 vs 25 ± 0.4 mm, P < 0.001; 41 ± 0.8 vs 34 ± 0.6 mm, P < 0.001; 36 ± 0.9 vs 30 ± 0.6 mm, P < 0.001, respectively). Following multivariable adjustment for age, sex, body surface area and ascending aortic diameter, these diameters remained larger in AI patients with a mean difference of 3, 6 and 4 mm, respectively (all P < 0.001). Mean AA diameter in the AI group was similar to the AS group (37 ± 1.0 vs 34 ± 0.8 mm, P = 0.06). Forty (69%) AI patients had BAV repair with a mean reduction in VAJ and STJ diameters of 5 and 9 mm compared with prerepair (P < 0.0001).
    Conclusions: Despite the absence of aortic aneurysms, aortic annulus and root dimensions are significantly larger in patients with BAV insufficiency compared with stenosis. Alterations in aortic root geometry contribute to the pathophysiology of BAV insufficiency and require correction for a successful repair.
    Mesh-Begriff(e) Aortic Valve/abnormalities ; Aortic Valve/pathology ; Aortic Valve/surgery ; Aortic Valve Insufficiency/epidemiology ; Aortic Valve Insufficiency/pathology ; Aortic Valve Insufficiency/surgery ; Aortic Valve Stenosis/epidemiology ; Aortic Valve Stenosis/pathology ; Aortic Valve Stenosis/surgery ; Bicuspid Aortic Valve Disease ; Female ; Heart Valve Diseases/epidemiology ; Heart Valve Diseases/pathology ; Heart Valve Diseases/surgery ; Humans ; Male ; Middle Aged ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2014-12-30
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezu499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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