Artikel ; Online: Estudio transversal de comorbilidades y medicaciones concomitantes en una cohorte de pacientes infectados por el virus de la inmunodeficiencia humana.
2016 Band 49, Heft 5, Seite(n) 286–293
Abstract: Aim: To assess the prevalence of comorbidities, concomitant therapies and adverse effects associated with the medication in a cohort of patients with HIV infection.: Design: Multicentre cross-sectional study.: Settings: Infectious Diseases or ... ...
Titelübersetzung | Cross sectional study of comorbidities and concomitant medications in a cohort of human immunodeficiency virus-infected patients. |
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Abstract | Aim: To assess the prevalence of comorbidities, concomitant therapies and adverse effects associated with the medication in a cohort of patients with HIV infection. Design: Multicentre cross-sectional study. Settings: Infectious Diseases or Internal Medicine outpatient Clinics of 3 hospitals in the Basque Country. Participants: During a 3 month period, patients with the following inclusion criteria were randomly selected: HIV infection, age>18years, antiretroviral treatment (ART) for at least 6months, and no changes in ART in the previous 4weeks. A total of 224 patients (of the 225 expected) were included. Measurements: Data were collected using a form, and include, epidemiological and anthropometric data, data related to HIV infection, comorbidities, current therapies, and adverse effects. Results: Of the 224 patients, 95.5% had at least one comorbidity, the most common being HCV infection (51.3%), dyslipidaemia (37.9%), diabetes mellitus or impaired fasting glucose (21.9%), and hypertension (21.9%). A total of 155 patients (69.2%) were taking concomitant medication: anxiolytics (21.4%), antihypertensives (19.6%), proton pump inhibitors (17.9%), statins (17%), and antidepressants (16.5%). Adverse effects (AE) were observed in 62.9% of subjects, the most common being, changes in body fat distribution (32.6%) and gastrointestinal (24.1%). Conclusions: Patients with HIV infection are getting older, with more comorbidities, with very frequent use of concomitant treatments, and high number of adverse effects. This requires a multidisciplinary approach and a coordinated effort within the Primary Care setting. |
Mesh-Begriff(e) | Adult ; Aged ; Cross-Sectional Studies ; Drug-Related Side Effects and Adverse Reactions ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Polypharmacy ; Young Adult |
Sprache | Spanisch |
Erscheinungsdatum | 2016-10-05 |
Erscheinungsland | Spain |
Dokumenttyp | Journal Article ; Multicenter Study ; Observational Study |
ZDB-ID | 1200787-0 |
ISSN | 1578-1275 ; 0212-6567 |
ISSN (online) | 1578-1275 |
ISSN | 0212-6567 |
DOI | 10.1016/j.aprim.2016.06.010 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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