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  1. Article ; Online: Acute myeloid leukemia development soon after anti-CD19 chimeric antigen receptor T-cell infusion in a patient with refractory diffuse large B-cell lymphoma and pre-existing clonal hematopoiesis.

    Falini, Lorenza / Venanzi, Alessandra / Tini, Valentina / Innocente, Alessandra / Ballanti, Stelvio / Saldi, Simonetta / Sivolella, Silvio / Pierini, Antonio / Aristei, Cynthia / Tiacci, Enrico / Perriello, Vincenzo Maria / Falini, Brunangelo

    Haematologica

    2023  Volume 108, Issue 1, Page(s) 290–294

    MeSH term(s) Humans ; Receptors, Chimeric Antigen/genetics ; Clonal Hematopoiesis ; Immunotherapy, Adoptive/adverse effects ; Receptors, Antigen, T-Cell/genetics ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/therapy ; T-Lymphocytes ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Antigens, CD19
    Chemical Substances Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell ; Antigens, CD19
    Language English
    Publishing date 2023-01-01
    Publishing country Italy
    Document type Case Reports
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Case Report: Subtotal Lymphoid and Total Marrow Irradiation as Bridge Therapy to CD19-Directed CAR T Cells in a Chemorefractory DLBCL With Leukemic Involvement.

    Saldi, Simonetta / Perriello, Vincenzo Maria / Falini, Lorenza / Ruggeri, Loredana / Fulcheri, Christian / Ciardelli, Sara / Innocente, Alessandra / Ballanti, Stelvio / Baffa, Nicodemo / Flenghi, Leonardo / Pierini, Antonio / Aristei, Cynthia / Falini, Brunangelo

    Frontiers in immunology

    2022  Volume 13, Page(s) 934700

    Abstract: CAR T cell therapy has transformed the salvage approach for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). Maintaining disease control before CAR T cell infusion during product manufacturing (so-called bridging therapy) is an important ... ...

    Abstract CAR T cell therapy has transformed the salvage approach for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). Maintaining disease control before CAR T cell infusion during product manufacturing (so-called bridging therapy) is an important step to optimizing outcome. Among possible bridging therapies, radiation therapy (RT) represents a valuable option, particularly when the disease is limited. Here, we report for the first time on a patient with chemorefractory-transformed DLBCL showing nodal, extranodal, and massive bone marrow (BM) lymphoma infiltration associated with leukemic involvement, a successful bridge therapy to CD19-directed CAR T cell therapy by subtotal lymphoid/total marrow irradiation plus thiothepa followed by reinfusion of CD34+ autologous hematopoietic stem cells. Such a novel bridging regimen allowed a significant reduction of nodal and BM tumor volume while improving blood cell count before CAR T cell infusion. The PET-CT scan and BM evaluation performed at 1, 3, and 6 months after treatment showed complete remission of the disease. A relapse occurred at almost 1 year in lymph nodes because of CD19 antigen escape while the BM remained free of disease. This extended radiotherapy approach may be an effective bridging therapy for chemorefractory DLBCL patients eligible for CAR T cells who present with a high tumor burden, including massive BM involvement associated with leukemic involvement. This preliminary evidence is worth confirming in additional patients.
    MeSH term(s) Antigens, CD19 ; Bone Marrow ; Humans ; Lymphoma, Large B-Cell, Diffuse/radiotherapy ; Neoplasm Recurrence, Local ; Positron Emission Tomography Computed Tomography ; T-Lymphocytes
    Chemical Substances Antigens, CD19
    Language English
    Publishing date 2022-07-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.934700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CAR T cell-driven cerebrospinal fluid cytokine storm with confounding neurological picture in chemorefractory primary cardiac lymphoma.

    Perriello, Vincenzo Maria / Falini, Lorenza / Ruggeri, Loredana / Innocente, Alessandra / Ballanti, Stelvio / Costa, Cinzia / Di Filippo, Massimiliano / Gargaro, Marco / Fallarino, Francesca / Falini, Brunangelo

    American journal of hematology

    2022  Volume 98, Issue 1, Page(s) 212–219

    MeSH term(s) Humans ; Cytokine Release Syndrome ; T-Lymphocytes ; Receptors, Antigen, T-Cell ; Lymphoma ; Immunotherapy, Adoptive ; Antigens, CD19
    Chemical Substances Receptors, Antigen, T-Cell ; Antigens, CD19
    Language English
    Publishing date 2022-11-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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