LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 270

Suchoptionen

  1. Buch: Biomedical nanosensors

    Irudayaraj, Joseph

    (Pan Stanford series on biomedical nanotechnology ; 3)

    2013  

    Verfasserangabe Joseph Irudayaraj ed
    Serientitel Pan Stanford series on biomedical nanotechnology ; 3
    Überordnung
    Schlagwörter Nanotechnologie ; Biomedizinische Technik
    Schlagwörter BMT ; Biomedical engineering ; Biomedizintechnik ; Submikrometertechnik ; Submikron-Technologie ; Nanotechnik ; Nanostrukturtechnik
    Sprache Englisch
    Umfang XII, 384 S., S. C2 - C12 : Ill., graph. Darst.
    Verlag Pan Stanford Publ
    Erscheinungsort Singapore
    Erscheinungsland Singapur
    Dokumenttyp Buch
    HBZ-ID HT016951079
    ISBN 978-981-4303-03-3 ; 981-4303-03-8 ; 9789814303040 ; 9814303046
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

  2. Buch: Nondestructive testing of food quality

    Irudayaraj, Joseph

    (IFT Press series)

    2008  

    Verfasserangabe ed.: Joseph Irudayaraj
    Serientitel IFT Press series
    Schlagwörter Food industry and trade/Quality control ; Food adulteration and inspection ; Food/Nondestructive testing
    Thema/Rubrik (Code) 664.07
    Sprache Englisch
    Umfang XIII, 364 S. : Ill., graph. Darst.
    Ausgabenhinweis 1. ed.
    Verlag Blackwell u.a.
    Erscheinungsort Ames, Iowa u.a.
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT014899742
    ISBN 0-8138-2885-6 ; 978-0-8138-2885-5
    Datenquelle Katalog ZB MED Ernährung, Umwelt, Agrar

    Zusatzmaterialien

    Kategorien

  3. Buch: Food processing operations modeling

    Irudayaraj, Joseph

    design and analysis

    (Food science and technology ; 107)

    2001  

    Verfasserangabe ed. by Joseph Irudayaraj
    Serientitel Food science and technology ; 107
    Überordnung
    Schlagwörter Lebensmittelverarbeitung ; Modell
    Schlagwörter Lebensmittel
    Sprache Englisch
    Umfang VIII, 347 S. : Ill., graph. Darst.
    Verlag Dekker
    Erscheinungsort New York u.a.
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT012971997
    ISBN 0-8247-0488-6 ; 978-0-8247-0488-9
    Datenquelle Katalog ZB MED Ernährung, Umwelt, Agrar

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Hierarchical encapsulation of bacteria in functional hydrogel beads for inter- and intra- species communication.

    Jeong, Yoon / Irudayaraj, Joseph

    Acta biomaterialia

    2023  Band 158, Seite(n) 203–215

    Abstract: To sequester prokaryotic cells in a biofilm-like niche, the creation of a pertinent and reliable microenvironment that reflects the heterogeneous nature of biological systems is vital for sustenance. Design of a microenvironment that is conducive for ... ...

    Abstract To sequester prokaryotic cells in a biofilm-like niche, the creation of a pertinent and reliable microenvironment that reflects the heterogeneous nature of biological systems is vital for sustenance. Design of a microenvironment that is conducive for growth and survival of organisms, should account for factors such as mass transport, porosity, stability, elasticity, size, functionality, and biochemical characteristics of the organisms in the confined architecture. In this work we present an artificial long-term confinement model fabricated by natural alginate hydrogels that are structurally stable and can host organisms for over 10 days in physiologically relevant conditions. A unique feature of the confinement platform is the development of stratified habitats wherein bacterial cells can be entrapped in the core as well as in the shell layers, wherein the thickness and the number of shell layers are tunable at fabrication. We show that the hydrogel microenvironment in the beads can host complex subpopulations of organisms similar to that in a biofilm. Dynamic interaction of bacterial colonies encapsulated in different beads or within the core and stratified layers of single beads was demonstrated to show intra- species communication. Inter- species communication between probiotic bacteria and human colorectal carcinoma cells was also demonstrated to highlight a possible bidirectional communication between the organisms in the beads and the environment. STATEMENT OF SIGNIFICANCE: Bacteria confinement in a natural soft hydrogel structure has always been a challenge due to the collapse of hydrogel architectures. Alternative methods have been attempted to encapsulate microorganisms by employing various processes to avoid/minimize rupturing of hydrogel structures. However, most of the past approaches have been unfavorable in balancing cell proliferation and functionality upon confinement. Our study addresses the fundamental gap in knowledge necessary to create favorable and complex 3D biofilm mimics utilizing natural hydrogel for microbial colonization for long-term studies. Our approach represents a cornerstone in the development of 3D functional architectures not only to advance studies in microbial communication, host-microbe interaction but also to address basic and fundamental questions in biology.
    Mesh-Begriff(e) Humans ; Hydrogels/chemistry ; Alginates/chemistry ; Bacteria ; Elasticity
    Chemische Substanzen Hydrogels ; Alginates
    Sprache Englisch
    Erscheinungsdatum 2023-01-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2023.01.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel ; Online: Dynamic Effect of β-Lactam Antibiotic Inactivation Due to the Inter- and Intraspecies Interaction of Drug-Resistant Microbes.

    Jeong, Yoon / Ahmad, Saeed / Irudayaraj, Joseph

    ACS biomaterials science & engineering

    2024  Band 10, Heft 3, Seite(n) 1461–1472

    Abstract: The presence of β-lactamase positive microorganisms imparts a pharmacological effect on a variety of organisms that can impact drug efficacy by influencing the function or composition of bacteria. Although studies to assess dynamic intra- and ... ...

    Abstract The presence of β-lactamase positive microorganisms imparts a pharmacological effect on a variety of organisms that can impact drug efficacy by influencing the function or composition of bacteria. Although studies to assess dynamic intra- and interspecies communication with bacterial communities exist, the efficacy of drug treatment and quantitative assessment of multiorganism response is not well understood due to the lack of technological advances that can be used to study coculture interactions in a dynamic format. In this study, we investigate how β-lactamase positive microorganisms can neutralize the effect of β-lactam antibiotics in a dynamic format at the inter- and intraspecies level using microbial bead technology. Three interactive models for the biological compartmentalization of organisms were demonstrated to evaluate the effect of β-lactam antibiotics on coculture systems. Our model at the intraspecies level attempts to mimic the biofilm matrix more closely as a community-level feature of microorganisms, which acknowledges the impact of nondrug-resistant species in shaping the dynamic response. In particular, the results of intraspecies studies are highly supportive of the biofilm mode of bacterial growth, which can provide structural support and protect the bacteria from an assault on host or environmental factors. Our findings also indicate that β-lactamase positive bacteria can neutralize the cytotoxic effect of β-lactam antibiotics at the interspecies level when cocultured with cancer cells. Results were validated using β-lactamase positive bacteria isolated from environmental niches, which can trigger phenotypical alteration of β-lactams when cocultured with other organisms. Our compartmentalization strategy acts as an independent ecosystem and provides a new avenue for multiscale studies to assess intra- and interspecies interactions.
    Mesh-Begriff(e) Anti-Bacterial Agents/chemistry ; Ecosystem ; beta-Lactamases/chemistry ; beta-Lactams/pharmacology ; beta-Lactams/chemistry ; Monobactams ; Bacteria ; beta Lactam Antibiotics
    Chemische Substanzen Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; beta-Lactams ; Monobactams ; beta Lactam Antibiotics
    Sprache Englisch
    Erscheinungsdatum 2024-02-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01678
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: Microbial β-Glucuronidase Hydrogel Beads Activate Chemotherapeutic Prodrug.

    Jeong, Yoon / Han, Xiaoxue / Vyas, Khushali / Irudayaraj, Joseph

    ACS applied materials & interfaces

    2024  Band 16, Heft 22, Seite(n) 28093–28103

    Abstract: Bacteria-assisted chemotherapeutics have been highlighted as an alternative or supplementary approach to treating cancer. However, dynamic cancer-microbe studies at ... ...

    Abstract Bacteria-assisted chemotherapeutics have been highlighted as an alternative or supplementary approach to treating cancer. However, dynamic cancer-microbe studies at the
    Mesh-Begriff(e) Prodrugs/chemistry ; Prodrugs/pharmacology ; Humans ; Glucuronidase/metabolism ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Lactococcus lactis/enzymology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor
    Chemische Substanzen Prodrugs ; Glucuronidase (EC 3.2.1.31) ; Hydrogels ; Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2024-05-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.4c02568
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: Magnetic Control-Enhanced Lateral Flow Technique for Ultrasensitive Nucleic Acid Target Detection.

    Ren, Wen / Irudayaraj, Joseph

    ACS omega

    2022  Band 7, Heft 33, Seite(n) 29204–29210

    Abstract: In this work, a lateral flow (LF)-based detection strategy termed magnetic control-enhanced LFA (MCLF) was proposed to detect nucleic acid sequences at attomolar sensitivity. In the proposed MCLF method, magnetic controllers which are magnetic ... ...

    Abstract In this work, a lateral flow (LF)-based detection strategy termed magnetic control-enhanced LFA (MCLF) was proposed to detect nucleic acid sequences at attomolar sensitivity. In the proposed MCLF method, magnetic controllers which are magnetic nanoparticles modified with antibodies against the labels on capture sequences were used to interact with the unreacted labeled capture sequence (CS-label) to improve the detection limit. By regulating the movement of magnetic probes (magnetic controllers) with a simple magnet under the lateral flow strip, the movement of magnetic probes bounded with unreacted CS-label in the sample flow could be reduced. Therefore, the target sequence-containing sandwich structures will arrive at the test zone prior, to interact with the recognition ligands, whereby the capture efficiency of the sandwich structures could be increased because the unreacted capture sequences at the test zone will be reduced. With the colorimetric signal from gold nanoparticle-based probes, the proposed MCLF technique could recognize as low as 100 aM of DNA target sequences by naked eyes, and the responding range of MCLF is from 100 aM to 10 pM.
    Sprache Englisch
    Erscheinungsdatum 2022-08-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c03276
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel ; Online: Multi-layered alginate hydrogel structures and bacteria encapsulation.

    Jeong, Yoon / Irudayaraj, Joseph

    Chemical communications (Cambridge, England)

    2022  Band 58, Heft 61, Seite(n) 8584–8587

    Abstract: We show the design and fabrication of finely tuned alginate core-shell capsules with precisely controllable core and hierarchical shell thickness at micron scale for scaleup for mass production. The method developed was used to encapsulate bacteria while ...

    Abstract We show the design and fabrication of finely tuned alginate core-shell capsules with precisely controllable core and hierarchical shell thickness at micron scale for scaleup for mass production. The method developed was used to encapsulate bacteria while maintaining morphology and mechanical stability of the bead without rupturing and cell leakage.
    Mesh-Begriff(e) Alginates/chemistry ; Bacteria ; Capsules/chemistry ; Hydrogels
    Chemische Substanzen Alginates ; Capsules ; Hydrogels
    Sprache Englisch
    Erscheinungsdatum 2022-07-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01187e
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Artikel: Multi-layered alginate hydrogel structures and bacteria encapsulation

    Jeong, Yoon / Irudayaraj, Joseph

    Chemical communications. 2022 July 28, v. 58, no. 61

    2022  

    Abstract: We show the design and fabrication of finely tuned alginate core–shell capsules with precisely controllable core and hierarchical shell thickness at micron scale for scaleup for mass production. The method developed was used to encapsulate bacteria while ...

    Abstract We show the design and fabrication of finely tuned alginate core–shell capsules with precisely controllable core and hierarchical shell thickness at micron scale for scaleup for mass production. The method developed was used to encapsulate bacteria while maintaining morphology and mechanical stability of the bead without rupturing and cell leakage.
    Schlagwörter alginates ; encapsulation ; hydrogels
    Sprache Englisch
    Erscheinungsverlauf 2022-0728
    Umfang p. 8584-8587.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01187e
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

  10. Artikel ; Online: In vitro toxicity of Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) on Human Renal and Hepatoma Cells.

    Zhang, Xing / Sands, Mia / Lin, Mindy / Guelfo, Jennifer / Irudayaraj, Joseph

    Toxicology reports

    2024  Band 12, Seite(n) 280–288

    Abstract: We evaluate the cytotoxicity, intracellular redox conditions, apoptosis, and methylation ... ...

    Abstract We evaluate the cytotoxicity, intracellular redox conditions, apoptosis, and methylation of
    Sprache Englisch
    Erscheinungsdatum 2024-03-01
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2024.02.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang