Artikel ; Online: Effect of collagen denaturation degree on mechanical properties and biological activity of nanofibrous scaffolds.
Journal of biomedical materials research. Part A
2023 Band 112, Heft 2, Seite(n) 144–154
Abstract: Further progress in regenerative medicine and bioengineering highly depends on the development of 3D polymeric scaffolds with active biological properties. The most attention is paid to natural extracellular matrix components, primarily collagen. Herein, ...
Abstract | Further progress in regenerative medicine and bioengineering highly depends on the development of 3D polymeric scaffolds with active biological properties. The most attention is paid to natural extracellular matrix components, primarily collagen. Herein, nonwoven nanofiber materials with various degrees of collagen denaturation and fiber diameters 250-500 nm were produced by electrospinning, stabilized by genipin, and characterized in detail. Collagen denaturation has been confirmed using DSC and FTIR analysis. The comparative study of collagen and gelatin nonwoven materials (NWM) revealed only minor differences in their biocompatibility with skin fibroblasts and keratinocytes in vitro. In long-term subcutaneous implantation study, the inflammation was less evident on collagen than on gelatin NWM. Remarkably, the pronounced calcification was revealed in the collagen NWM only. The results obtained can be useful in terms of improving the electrospinning technology of collagen from aqueous solutions, as well as emphasize the importance of long-term study to ensure proper implementation of the material, taking into account the ability of collagen to provoke calcification. |
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Mesh-Begriff(e) | Nanofibers ; Tissue Scaffolds ; Gelatin/pharmacology ; Tissue Engineering/methods ; Collagen/pharmacology |
Chemische Substanzen | Gelatin (9000-70-8) ; Collagen (9007-34-5) |
Sprache | Englisch |
Erscheinungsdatum | 2023-11-03 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2099989-6 |
ISSN | 1552-4965 ; 1549-3296 ; 0021-9304 |
ISSN (online) | 1552-4965 |
ISSN | 1549-3296 ; 0021-9304 |
DOI | 10.1002/jbm.a.37598 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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