Artikel: Oral administration of a casein matrix containing β-casofensin protects the intestinal barrier in two preclinical models of gut diseases
Journal of functional foods. 2016 Dec., v. 27
2016
Abstract: β-Casofensin is a milk-derived bioactive peptide that interacts with intestinal goblet cells. We aimed to determine whether β-casofensin could prevent intestinal dysfunctions induced by neonatal maternal separation (NMS) and whether it retains its ... ...
| Abstract | β-Casofensin is a milk-derived bioactive peptide that interacts with intestinal goblet cells. We aimed to determine whether β-casofensin could prevent intestinal dysfunctions induced by neonatal maternal separation (NMS) and whether it retains its protective effects when administered in a casein matrix. We also evaluated whether a casein matrix enriched in β-casofensin protects against intestinal enteritis induced by indomethacin. β-Casofensin abolished NMS-induced jejunal hyperpermeability and prevented the depletion of goblet and Paneth cells induced by NMS. In addition, β-casofensin maintained its effectiveness against NMS-induced intestinal barrier alterations when administered in a casein matrix. A casein matrix containing β-casofensin also reduced intestinal damages induced by indomethacin. A functional food containing β-casofensin may prevent both the deleterious effects of neonatal stress on the intestinal barrier and indomethacin-induced enteritis. These results suggest a promising application of β-casofensin as a gut barrier protector in the context of bioactive foods and clinical nutrition. |
|||||
|---|---|---|---|---|---|---|
| Schlagwörter | absorption barrier ; casein ; clinical nutrition ; enteritis ; functional foods ; goblet cells ; indomethacin ; jejunum ; models ; oral administration ; protective effect | |||||
| Sprache | Englisch | |||||
| Erscheinungsverlauf | 2016-12 | |||||
| Umfang | p. 223-235. | |||||
| Erscheinungsort | Elsevier Ltd | |||||
| Dokumenttyp | Artikel | |||||
| ZDB-ID | 2511964-3 | |||||
| ISSN | 1756-4646 | |||||
| ISSN | 1756-4646 | |||||
| DOI | 10.1016/j.jff.2016.09.007 | |||||
| Signatur |
|
|||||
| Datenquelle | NAL Katalog (AGRICOLA) |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Bonn
| Z 7830: Hefte anzeigen |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.
Fernleihe an ZB MED
Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.