Article ; Online: Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro.
Chinese journal of natural medicines
2020 Volume 18, Issue 9, Page(s) 704–713
Abstract: Chinese herbal compound Nao-Fu-Cong (NFC) has been mainly used to treat cognitive disorders in Traditional Chinese Medicine (TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of JNK/CHOP/ ... ...
Abstract | Chinese herbal compound Nao-Fu-Cong (NFC) has been mainly used to treat cognitive disorders in Traditional Chinese Medicine (TCM). The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of JNK/CHOP/Bcl2-mediated apoptosis pathway or not. We randomly assigned STZ (60 mg·kg |
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MeSH term(s) | Acetylcysteine/pharmacology ; Animals ; Anthracenes/pharmacology ; Apoptosis/drug effects ; Cognitive Dysfunction/drug therapy ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/physiopathology ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Hippocampus/drug effects ; MAP Kinase Signaling System/drug effects ; Male ; Membrane Potential, Mitochondrial/drug effects ; Neurons/drug effects ; Neuroprotective Agents/pharmacology ; Proto-Oncogene Proteins c-bcl-2/drug effects ; Random Allocation ; Rats ; Transcription Factor CHOP/antagonists & inhibitors |
Chemical Substances | Anthracenes ; Bcl2 protein, rat ; Drugs, Chinese Herbal ; Neuroprotective Agents ; Proto-Oncogene Proteins c-bcl-2 ; naofucong ; Transcription Factor CHOP (147336-12-7) ; pyrazolanthrone (1TW30Y2766) ; Acetylcysteine (WYQ7N0BPYC) |
Language | English |
Publishing date | 2020-08-12 |
Publishing country | China |
Document type | Journal Article |
ZDB-ID | 2192577-X |
ISSN | 1875-5364 ; 2095-6975 ; 1672-3651 |
ISSN (online) | 1875-5364 |
ISSN | 2095-6975 ; 1672-3651 |
DOI | 10.1016/S1875-5364(20)60009-7 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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