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  1. Artikel: Induced

    Withatanung, Patoo / Janesomboon, Sujintana / Vanaporn, Muthita / Muangsombut, Veerachat / Charoensudjai, Sorujsiri / Baker, Dave J / Wuthiekanun, Vanaporn / Galyov, Edouard E / Clokie, Martha R J / Gundogdu, Ozan / Korbsrisate, Sunee

    Frontiers in microbiology

    2024  Band 15, Seite(n) 1361121

    Abstract: Bacteriophages (phages), viruses that infect bacteria, are found in abundance not only in the environment but also in the human body. The use of phages for the diagnosis of melioidosis, a tropical infectious disease caused ... ...

    Abstract Bacteriophages (phages), viruses that infect bacteria, are found in abundance not only in the environment but also in the human body. The use of phages for the diagnosis of melioidosis, a tropical infectious disease caused by
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1361121
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Lymphostatin, a virulence factor of attaching and effacing

    Ruamsap, Nattaya / Riyapa, Donporn / Janesomboon, Sujintana / Stevens, Joanne M / Pichyangkul, Sathit / Pattanapanyasat, Kovit / Demons, Samandra T / Stevens, Mark P / Korbsrisate, Sunee

    Frontiers in cellular and infection microbiology

    2022  Band 12, Seite(n) 941939

    Abstract: Lymphostatin is a virulence factor of ... ...

    Abstract Lymphostatin is a virulence factor of enteropathogenic
    Mesh-Begriff(e) Apoptosis ; Bacterial Toxins/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Cycle Checkpoints/immunology ; Cell Division ; Cell Proliferation/physiology ; Cytokines/biosynthesis ; Cytokines/immunology ; Enteropathogenic Escherichia coli/immunology ; Enteropathogenic Escherichia coli/pathogenicity ; Escherichia coli/immunology ; Escherichia coli/pathogenicity ; Escherichia coli Infections/immunology ; Escherichia coli Proteins/immunology ; Humans ; Interleukin-2 ; Interleukin-4 ; Leukocytes, Mononuclear/immunology ; Necrosis ; T-Lymphocytes/immunology ; Virulence Factors/immunology
    Chemische Substanzen Bacterial Toxins ; Cytokines ; Escherichia coli Proteins ; Interleukin-2 ; Virulence Factors ; lymphostatin protein, E coli ; Interleukin-4 (207137-56-2)
    Sprache Englisch
    Erscheinungsdatum 2022-07-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.941939
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Analysis of the role of the QseBC two-component sensory system in epinephrine-induced motility and intracellular replication of Burkholderia pseudomallei.

    Meethai, Chatruthai / Vanaporn, Muthita / Intarak, Narin / Lerdsittikul, Varintip / Withatanung, Patoo / Janesomboon, Sujintana / Vattanaviboon, Paiboon / Chareonsudjai, Sorujsiri / Wilkinson, Toby / Stevens, Mark P / Stevens, Joanne M / Korbsrisate, Sunee

    PloS one

    2023  Band 18, Heft 2, Seite(n) e0282098

    Abstract: Burkholderia pseudomallei is a facultative intracellular bacterial pathogen that causes melioidosis, a severe invasive disease of humans. We previously reported that the stress-related catecholamine hormone epinephrine enhances motility of B. ... ...

    Abstract Burkholderia pseudomallei is a facultative intracellular bacterial pathogen that causes melioidosis, a severe invasive disease of humans. We previously reported that the stress-related catecholamine hormone epinephrine enhances motility of B. pseudomallei, transcription of flagellar genes and the production of flagellin. It has been reported that the QseBC two-component sensory system regulates motility and virulence-associated genes in other Gram-negative bacteria in response to stress-related catecholamines, albeit disparities between studies exist. We constructed and whole-genome sequenced a mutant of B. pseudomallei with a deletion spanning the predicted qseBC homologues (bpsl0806 and bpsl0807). The ΔqseBC mutant exhibited significantly reduced swimming and swarming motility and reduced transcription of fliC. It also exhibited a defect in biofilm formation and net intracellular survival in J774A.1 murine macrophage-like cells. While epinephrine enhanced bacterial motility and fliC transcription, no further reduction in these phenotypes was observed with the ΔqseBC mutant in the presence of epinephrine. Plasmid-mediated expression of qseBC suppressed bacterial growth, complicating attempts to trans-complement mutant phenotypes. Our data support a role for QseBC in motility, biofilm formation and net intracellular survival of B. pseudomallei, but indicate that it is not essential for epinephrine-induced motility per se.
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Burkholderia pseudomallei/metabolism ; Epinephrine/pharmacology ; Epinephrine/metabolism ; Flagellin/metabolism ; Melioidosis
    Chemische Substanzen Bacterial Proteins ; Epinephrine (YKH834O4BH) ; Flagellin (12777-81-0)
    Sprache Englisch
    Erscheinungsdatum 2023-02-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0282098
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Rapid Clinical Screening of Burkholderia pseudomallei Colonies by a Bacteriophage Tail Fiber-Based Latex Agglutination Assay.

    Muangsombut, Veerachat / Withatanung, Patoo / Chantratita, Narisara / Chareonsudjai, Sorujsiri / Lim, Jiali / Galyov, Edouard E / Ottiwet, Orawan / Sengyee, Sineenart / Janesomboon, Sujintana / Loessner, Martin J / Dunne, Matthew / Korbsrisate, Sunee

    Applied and environmental microbiology

    2021  Band 87, Heft 12, Seite(n) e0301920

    Abstract: Melioidosis is a life-threatening disease in humans caused by the Gram-negative bacterium Burkholderia pseudomallei. As severe septicemic melioidosis can lead to death within 24 to 48 h, a rapid diagnosis of melioidosis is critical for ensuring that an ... ...

    Abstract Melioidosis is a life-threatening disease in humans caused by the Gram-negative bacterium Burkholderia pseudomallei. As severe septicemic melioidosis can lead to death within 24 to 48 h, a rapid diagnosis of melioidosis is critical for ensuring that an optimal antibiotic course is prescribed to patients. Here, we report the development and evaluation of a bacteriophage tail fiber-based latex agglutination assay for rapid detection of B. pseudomallei infection.
    Mesh-Begriff(e) Bacteriophages ; Burkholderia pseudomallei/genetics ; Burkholderia pseudomallei/virology ; Capsid Proteins ; Humans ; Latex Fixation Tests ; Melioidosis/diagnosis ; Melioidosis/microbiology ; Sensitivity and Specificity
    Chemische Substanzen Capsid Proteins ; gene 24 protein, Enterobacteria phage T4 ; gp23 protein, Bacteriophage T4
    Sprache Englisch
    Erscheinungsdatum 2021-05-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/AEM.03019-20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Detection and differentiation of Burkholderia species with pathogenic potential in environmental soil samples.

    Janesomboon, Sujintana / Muangsombut, Veerachat / Srinon, Varintip / Meethai, Chatruthai / Tharinjaroen, Chayada S / Amornchai, Premjit / Withatanung, Patoo / Chantratita, Narisara / Mayo, Mark / Wuthiekanun, Vanaporn / Currie, Bart J / Stevens, Joanne M / Korbsrisate, Sunee

    PloS one

    2021  Band 16, Heft 1, Seite(n) e0245175

    Abstract: The Burkholderia pseudomallei phylogenetic cluster includes B. pseudomallei, B. mallei, B. thailandensis, B. oklahomensis, B. humptydooensis and B. singularis. Regarded as the only pathogenic members of this group, B. pseudomallei and B. mallei cause the ...

    Abstract The Burkholderia pseudomallei phylogenetic cluster includes B. pseudomallei, B. mallei, B. thailandensis, B. oklahomensis, B. humptydooensis and B. singularis. Regarded as the only pathogenic members of this group, B. pseudomallei and B. mallei cause the diseases melioidosis and glanders, respectively. Additionally, variant strains of B. pseudomallei and B. thailandensis exist that include the geographically restricted B. pseudomallei that express a B. mallei-like BimA protein (BPBM), and B. thailandensis that express a B. pseudomallei-like capsular polysaccharide (BTCV). To establish a PCR-based assay for the detection of pathogenic Burkholderia species or their variants, five PCR primers were designed to amplify species-specific sequences within the bimA (Burkholderia intracellular motility A) gene. Our multiplex PCR assay could distinguish pathogenic B. pseudomallei and BPBM from the non-pathogenic B. thailandensis and the BTCV strains. A second singleplex PCR successfully discriminated the BTCV from B. thailandensis. Apart from B. humptydooensis, specificity testing against other Burkholderia spp., as well as other Gram-negative and Gram-positive bacteria produced a negative result. The detection limit of the multiplex PCR in soil samples artificially spiked with known quantities of B. pseudomallei and B. thailandensis were 5 and 6 CFU/g soil, respectively. Furthermore, comparison between standard bacterial culture and the multiplex PCR to detect B. pseudomallei from 34 soil samples, collected from an endemic area of melioidosis, showed high sensitivity and specificity. This robust, sensitive, and specific PCR assay will be a useful tool for epidemiological study of B. pseudomallei and closely related members with pathogenic potential in soil.
    Mesh-Begriff(e) Burkholderia/genetics ; Burkholderia/isolation & purification ; Burkholderia/pathogenicity ; DNA Barcoding, Taxonomic/methods ; Microbiota ; Polymerase Chain Reaction/methods ; Soil Microbiology
    Sprache Englisch
    Erscheinungsdatum 2021-01-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0245175
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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