Artikel ; Online: Vascular ultrasound for cardiovascular risk stratification in asymptomatic patients with type-2 diabetes.
2021 Band 15, Heft 4, Seite(n) 726–732
Abstract: Aims: To identify new independent vascular markers to predict cardiovascular events in patients with type-2 diabetes (T2D), and their incremental value compared to the Swedish National Diabetes Register (NDR) risk score.: Methods: A retrospective ... ...
| Abstract | Aims: To identify new independent vascular markers to predict cardiovascular events in patients with type-2 diabetes (T2D), and their incremental value compared to the Swedish National Diabetes Register (NDR) risk score. Methods: A retrospective cohort study was conducted on 1332 asymptomatic patients with T2D, free from prior CV event, assessed for a cardiovascular work-up, including Duplex ultrasonography to detect plaque on carotid and femoral arteries. The extent of atherosclerosis was rated as atherosclerosis burden score (ABS). Patients were followed up to 5 years and the occurrence of cardiovascular events recorded. Results: A total of 82 patients (6.2%) experienced a cardiovascular event, including 34 (2.6%) myocardial infarction, 18 (1.4%) cardiac revascularisation and 17 (1.3%) stroke. The independent determinants of these events were male sex (HR = 1.81 [1.13-2.88], p = 0.013) and ABS ≥ 2 (HR = 1.98 [1.21-3.25], p = 0.007). The NDR risk score performed poorly to predict cardiovascular events (area under the curve = 0.56 [0.49-0.63], p = 0.11), whereas screening for atherosclerotic plaques provided significant incremental prognostic value over the NDR score (model χ2 increase: +231%, p = 0.002). Conclusion: Duplex ultrasonography to screen for atherosclerotic plaques improve the estimation of cardiovascular prognosis on top of clinical data and could be routinely used to improve cardiovascular risk stratification. |
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| Mesh-Begriff(e) | Cardiovascular Diseases/diagnostic imaging ; Cardiovascular Diseases/epidemiology ; Diabetes Mellitus, Type 2/diagnostic imaging ; Diabetes Mellitus, Type 2/epidemiology ; Heart Disease Risk Factors ; Humans ; Male ; Retrospective Studies ; Risk Assessment ; Risk Factors |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-04-23 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2273997-X |
| ISSN | 1878-0210 ; 1751-9918 |
| ISSN (online) | 1878-0210 |
| ISSN | 1751-9918 |
| DOI | 10.1016/j.pcd.2021.04.006 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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