Article ; Online: Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects.
International journal of molecular sciences
2023 Volume 24, Issue 11
Abstract: Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different ... ...
| Abstract | Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs. |
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| MeSH term(s) | Animals ; Arthritis, Psoriatic/metabolism ; Proteomics ; Psoriasis/metabolism ; Metabolomics ; Biomarkers/metabolism |
| Chemical Substances | Biomarkers |
| Language | English |
| Publishing date | 2023-05-30 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms24119507 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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