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  1. Artikel ; Online: Shikonin prevents mice from heat stroke-induced death via suppressing a trigger IL-17A on the inflammatory and oxidative pathways.

    Luo, Qiong / Ji, Xin Ye / Zhang, Liang / Huang, Xin / Wang, Xiao Qin / Zhang, Bo

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Band 166, Seite(n) 115346

    Abstract: Heat stroke (HS) is the deadliest disease. Due to the complex pathogenesis of HS, lack of effective therapeutic drugs for clinical treatment. Shikonin (SK) is the main active compound of Radix Arnebiae, which was evaluated on the HS model (temperature: ( ... ...

    Abstract Heat stroke (HS) is the deadliest disease. Due to the complex pathogenesis of HS, lack of effective therapeutic drugs for clinical treatment. Shikonin (SK) is the main active compound of Radix Arnebiae, which was evaluated on the HS model (temperature: (41 ± 0.5) ℃, relative humidity: (60 ± 5) %) via pathological and biochemical approaches in vivo and in vitro. Upon the dose of 10 mg.kg
    Mesh-Begriff(e) Animals ; Mice ; Interleukin-17 ; Heat Stroke/drug therapy ; Naphthoquinones/pharmacology ; Naphthoquinones/therapeutic use ; Oxidative Stress
    Chemische Substanzen Interleukin-17 ; shikonin (3IK6592UBW) ; Naphthoquinones
    Sprache Englisch
    Erscheinungsdatum 2023-08-27
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115346
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data.

    Wang, Qian-Qian / Sun, Qin-Rong / Ji, Xin-Ye / Tang, Yun / Zhang, Ke / Wang, Xiao-Qin / Li, Hong-Rui / Huang, Xiang-Zhong / Zhang, Bo

    Journal of ethnopharmacology

    2022  Band 303, Seite(n) 115990

    Abstract: Ethnopharmacology relevance: As a Yi medicine for eliminating wind to relieve pain, Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo (TSY) is widely used to treat sore throat, stomach pain, bone and muscle injuries, and tumors; however, the ... ...

    Abstract Ethnopharmacology relevance: As a Yi medicine for eliminating wind to relieve pain, Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo (TSY) is widely used to treat sore throat, stomach pain, bone and muscle injuries, and tumors; however, the material basis and mechanism of action remain unclear.
    Aim of the study: This study aims to investigate the potential active compounds of TSY and related pharmacological mechanisms against gastric cancer using a multitarget strategy.
    Materials and methods: The main chemical components of TSY were collected through a literature review and database searches. The components were further screened for ADMET properties, and their targets were predicted using network pharmacology (admetSAR) and substructure-drug-target network-based inference (SDTNBI) approaches in silico. The pharmacological mechanism of action of TSY extract for pain relief, sedation, and anti-gastric cancer activities were identified via in vivo and in vitro biochemical analyses.
    Results: Here, 28 chemical components were identified, 7 active compounds were selected, and 75 targets of TSY extract were predicted. A compound-target-disease network topological approach revealed that the predicted targets are highly related to the digestive system and nervous system. Network pharmacology results suggested that the anti-gastric cancer activity of TSY was highly correlated with its analgesic and sedative targets and MAPK. In vivo experiments confirmed that TSY extract not only reduced the number of voluntary activities in the mouse model but also exhibited a synergistic effect on sodium pentobarbital-induced sleep, reduced the number of mice exhibiting writhing responses to acetic acid, and increased the hot plate pain threshold of mice. Thus, TSY extract exhibits good analgesic and sedative effects. The TSY extract inhibited HGC-27 cell proliferation and induced apoptosis by regulating apoptotic proteins (BAX, BCL-2 and BCL-XL) in vitro.
    Conclusions: TSY exhibits combined analgesic, sedative, and anti-gastric cancer activities.
    Sprache Englisch
    Erscheinungsdatum 2022-12-09
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115990
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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