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  1. Artikel ; Online: Does ChatGPT Play a Double-Edged Sword Role in the Field of Higher Education? An In-Depth Exploration of the Factors Affecting Student Performance

    Jiangjie Chen / Ziqing Zhuo / Jiacheng Lin

    Sustainability, Vol 15, Iss 24, p

    2023  Band 16928

    Abstract: The application of generative artificial intelligence in the field of education has been receiving increasing attention, with the performance of chatbot ChatGPT being particularly prominent. This study aims to explore in depth the performance impact on ... ...

    Abstract The application of generative artificial intelligence in the field of education has been receiving increasing attention, with the performance of chatbot ChatGPT being particularly prominent. This study aims to explore in depth the performance impact on higher education students utilizing ChatGPT. To this end, we conducted a survey on 448 university students and employed the partial-least squares (PLS) method of structural equation modeling for data analysis. The results indicate that all eight hypothetical paths posited in this study were supported, and surprisingly, the hypothesis that technology characteristics have a direct effect on performance impact was supported. Moreover, the study found that overall quality is a crucial factor determining performance impact. Overall quality indirectly affects performance impact through task-technology fit, technology characteristics, and compatibility, among which the mediating effect of compatibility is most significant, followed by technology characteristics. This study offers practical recommendations for students on the proper use of ChatGPT during the learning process and assists developers in enhancing the services of the ChatGPT system.
    Schlagwörter generative artificial intelligence ; higher education ; ChatGPT ; overall quality ; performance impact ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 690
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Effect analysis of a virtual simulation experimental platform in teaching pulpotomy

    Jiaxuan Lu / Xin Yang / Wei Zhao / Jiacheng Lin

    BMC Medical Education, Vol 22, Iss 1, Pp 1-

    2022  Band 8

    Abstract: Abstract Background The experimental teaching of pediatric dentistry is a bridge between theoretical study and clinical practice, and virtual simulation technology provides a new method of instruction. Methods We built an experimental teaching platform ... ...

    Abstract Abstract Background The experimental teaching of pediatric dentistry is a bridge between theoretical study and clinical practice, and virtual simulation technology provides a new method of instruction. Methods We built an experimental teaching platform using virtual simulation technology for vital pulpotomy that includes learning and examination modes. A total of 199 students majoring in stomatology in the fourth year at Sun Yat-Sen University were randomly divided into a control group (conventional teaching mode) and an experimental group (virtual simulation experimental teaching model). The teaching effect was evaluated by theoretical and experimental examination. Results We found that both the theoretical and experimental scores of the experimental group were higher than those of the control group, and the theoretical scores of the experimental group after exposure to the virtual simulation experimental teaching platform were also higher than those before the class, with significant differences (P < 0.05). Feedback from the experimental group after the class indicated that the platform reinforced their theoretical knowledge and greatly improved their mastery of operational skills. Conclusions The application of a virtual simulation experimental teaching platform can effectively improve the teaching of pulpotomy.
    Schlagwörter Virtual simulation experimental teaching ; Virtual simulation experimental teaching platform ; Experimental teaching ; Pulpotomy ; Pediatric dentistry ; Special aspects of education ; LC8-6691 ; Medicine ; R
    Thema/Rubrik (Code) 370
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
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  3. Artikel: Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions

    Qinwufeng, Gu / Jiacheng, Lin / Xiaoling, Lu / Tingru, Chen / Yunyang, Wu / Yanlong, Yang

    Journal of ethnopharmacology. 2022 Sept. 15, v. 295

    2022  

    Abstract: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, the mechanism of JWYA remains ... ...

    Abstract Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, the mechanism of JWYA remains unclear. Aim of the study: This study aimed to investigate the effect of JWYA on an experimental mouse AD model. Mice were sensitized with 2,4-dinitrochlorobenzene (DNCB) and intragastrically administered with JWYA for 14 days. The therapeutic effect was assessed using a grade four dermatitis score, skin moisture, thickness measurements, and a mouse behavior tests. H&E and toluidine blue staining were used to observe epidermal inflammatory thickening and mast cells in mouse skin lesions. Serum IgE levels and skin TNF-α and IL-4 levels were determined using ELISAs. The TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ mRNA expression levels in skin lesions were detected using qPCR. Network pharmacology analysis based on serum active components was performed to elucidate the mechanism, and the results were verified by Western blotting. Finally, we tested the binding affinity between the active ingredients of JWYA and JAK1 via molecular docking. JWYA improved the skin lesions of AD mice, relieved itching and reduced skin thickening. Additionally, JWYA decreased the serum IgE level and the levels of TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ in skin. Moreover, JWYA inhibited the activation of JAK1/STAT3 and MAPK (p38, ERK, and JNK) signaling. Molecular docking showed that kaempferol, luteolin, and forsythin have high affinity for JAK1. JWYA alleviates AD-like skin lesions and inhibited inflammation and skin itch. The effect of JWYA is attributed to blocking the JAK1/STAT3 and MAPK signaling pathways. We suggest that JWYA may be an alternative therapy for the treatment of AD.
    Schlagwörter Oriental traditional medicine ; atopic dermatitis ; blood serum ; gene expression ; inflammation ; interleukin-13 ; interleukin-4 ; kaempferol ; luteolin ; mice ; models ; pharmacology ; therapeutics ; toluidine blue
    Sprache Englisch
    Erscheinungsverlauf 2022-0915
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115428
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions.

    Qinwufeng, Gu / Jiacheng, Lin / Xiaoling, Lu / Tingru, Chen / Yunyang, Wu / Yanlong, Yang

    Journal of ethnopharmacology

    2022  Band 295, Seite(n) 115428

    Abstract: Ethnopharmacological relevance: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, ... ...

    Abstract Ethnopharmacological relevance: Jiu-Wei-Yong-An (JWYA) formula is a traditional Chinese medicine (TCM) prescription used to treat atopic dermatitis (AD) in the clinic. JWYA is considered to have anti-inflammatory and antipruritic properties. However, the mechanism of JWYA remains unclear.
    Aim of the study: This study aimed to investigate the effect of JWYA on an experimental mouse AD model.
    Materials and methods: Mice were sensitized with 2,4-dinitrochlorobenzene (DNCB) and intragastrically administered with JWYA for 14 days. The therapeutic effect was assessed using a grade four dermatitis score, skin moisture, thickness measurements, and a mouse behavior tests. H&E and toluidine blue staining were used to observe epidermal inflammatory thickening and mast cells in mouse skin lesions. Serum IgE levels and skin TNF-α and IL-4 levels were determined using ELISAs. The TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ mRNA expression levels in skin lesions were detected using qPCR. Network pharmacology analysis based on serum active components was performed to elucidate the mechanism, and the results were verified by Western blotting. Finally, we tested the binding affinity between the active ingredients of JWYA and JAK1 via molecular docking.
    Results: JWYA improved the skin lesions of AD mice, relieved itching and reduced skin thickening. Additionally, JWYA decreased the serum IgE level and the levels of TNF-α, IL-1β, IL-4, IL-13, IL-31, IL-33, and IFN-γ in skin. Moreover, JWYA inhibited the activation of JAK1/STAT3 and MAPK (p38, ERK, and JNK) signaling. Molecular docking showed that kaempferol, luteolin, and forsythin have high affinity for JAK1.
    Conclusions: JWYA alleviates AD-like skin lesions and inhibited inflammation and skin itch. The effect of JWYA is attributed to blocking the JAK1/STAT3 and MAPK signaling pathways. We suggest that JWYA may be an alternative therapy for the treatment of AD.
    Mesh-Begriff(e) Animals ; Cytokines/metabolism ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/metabolism ; Dinitrochlorobenzene ; Immunoglobulin E ; Interleukin-13/metabolism ; Interleukin-33/metabolism ; Interleukin-4/metabolism ; MAP Kinase Signaling System ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Plant Extracts/pharmacology ; Skin/pathology ; Tumor Necrosis Factor-alpha/metabolism
    Chemische Substanzen Cytokines ; Dinitrochlorobenzene ; Interleukin-13 ; Interleukin-33 ; Plant Extracts ; Tumor Necrosis Factor-alpha ; Interleukin-4 (207137-56-2) ; Immunoglobulin E (37341-29-0)
    Sprache Englisch
    Erscheinungsdatum 2022-05-31
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115428
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Hefte anzeigen Standort:
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  5. Artikel ; Online: Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy.

    Jiacheng Lin / Limin Yin / Xia-Zhen Xu / He-Chen Sun / Zhi-Hua Huang / Xue-Yun Ni / Yan Chen / Xu Lin

    PLoS Pathogens, Vol 18, Iss 1, p e

    2022  Band 1010204

    Abstract: The hepatitis B virus (HBV) core protein (HBc) functions in multiple steps of the viral life cycle. Heteroaryldihydropyrimidine compounds (HAPs) such as Bay41-4109 are capsid protein allosteric modulators that accelerate HBc degradation and inhibit the ... ...

    Abstract The hepatitis B virus (HBV) core protein (HBc) functions in multiple steps of the viral life cycle. Heteroaryldihydropyrimidine compounds (HAPs) such as Bay41-4109 are capsid protein allosteric modulators that accelerate HBc degradation and inhibit the virion secretion of HBV, specifically by misleading HBc assembly into aberrant non-capsid polymers. However, the subsequent cellular fates of these HAP-induced aberrant non-capsid polymers are not well understood. Here, we discovered that that the chaperone-binding E3 ubiquitin ligase protein STUB1 is required for the removal of Bay41-4109-induced aberrant non-capsid polymers from HepAD38 cells. Specifically, STUB1 recruits BAG3 to transport Bay41-4109-induced aberrant non-capsid polymers to the perinuclear region of cells, thereby initiating p62-mediated macroautophagy and lysosomal degradation. We also demonstrate that elevating the STUB1 level enhances the inhibitory effect of Bay41-4109 on the production of HBeAg and HBV virions in HepAD38 cells, in HBV-infected HepG2-NTCP cells, and in HBV transgenic mice. STUB1 overexpression also facilitates the inhibition of Bay41-4109 on the cccDNA formation in de novo infection of HBV. Understanding these molecular details paves the way for applying HAPs as a potentially curative regimen (or a component of a combination treatment) for eradicating HBV from hepatocytes of chronic infection patients.
    Schlagwörter Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  6. Artikel ; Online: Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

    Jun Dong / Li Chen / Fei Ye / Junhui Tang / Bing Liu / Jiacheng Lin / Pang-Hu Zhou / Bin Lu / Min Wu / Jia-Hong Lu / Jing-Jing He / Simone Engelender / Qingtao Meng / Zhiyin Song / He He

    Nature Communications, Vol 15, Iss 1, Pp 1-

    2024  Band 16

    Abstract: Abstract Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain ... ...

    Abstract Abstract Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticulum-mitochondrial contacts remain unclear. Here, we show that Mic19, a key subunit of MICOS (mitochondrial contact site and cristae organizing system) complex, regulates ER-mitochondria contacts by the EMC2-SLC25A46-Mic19 axis. Mic19 liver specific knockout (LKO) leads to the reduction of ER-mitochondrial contacts, mitochondrial lipid metabolism disorder, disorganization of mitochondrial cristae and mitochondrial unfolded protein stress response in mouse hepatocytes, impairing liver mitochondrial fatty acid β-oxidation and lipid metabolism, which may spontaneously trigger nonalcoholic steatohepatitis (NASH) and liver fibrosis in mice. Whereas, the re-expression of Mic19 in Mic19 LKO hepatocytes blocks the development of liver disease in mice. In addition, Mic19 overexpression suppresses MCD-induced fatty liver disease. Thus, our findings uncover the EMC2-SLC25A46-Mic19 axis as a pathway regulating ER-mitochondria contacts, and reveal that impairment of ER-mitochondria contacts may be a mechanism associated with the development of NASH and liver fibrosis.
    Schlagwörter Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
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  7. Artikel ; Online: Potential effects of different cell death inhibitors in protecting against ischemia-reperfusion injury in steatotic liver.

    Junzhe, Jiao / Meng, Li / Weifan, Huang / Min, Xu / Jiacheng, Lin / Yihan, Qian / Ke, Zhen / Fang, Wang / Dongwei, Xu / Hailong, Wu / Xiaoni, Kong

    International immunopharmacology

    2024  Band 128, Seite(n) 111545

    Abstract: Liver ischemia-reperfusion injury (IRI) remains a common issue and with the increasing incidence of Nonalcoholic fatty liver disease (NAFLD), which are more sensitive to IRI, it is crucial to explore the possible strategy to alleviate the steatotic liver ...

    Abstract Liver ischemia-reperfusion injury (IRI) remains a common issue and with the increasing incidence of Nonalcoholic fatty liver disease (NAFLD), which are more sensitive to IRI, it is crucial to explore the possible strategy to alleviate the steatotic liver IRI. Several modes of cell death are involved in hepatocytes and immune cells during hepatic IRI, and the effects of different cell death inhibitors including apoptosis, necroptosis, pyroptosis, and ferroptosis in steatotic liver IRI have not been investigated. We established 70% IRI model on steatotic liver in mice. Apoptosis, necroptosis, pyroptosis and ferroptosis inhibitors were used to evaluate their effects on liver injury, inflammatory response, and immune cell infiltration. Immunofluorescence and immunohistochemical results demonstrated that there were apoptosis, necroptosis, pyroptosis, and ferroptosis in the progression of IRI in steatotic liver. All four types of cell death inhibitors showed protective effects, but ferroptosis inhibitor Fer-1 and pyroptosis inhibitor VX765 exerted better protective effects compared the apoptosis inhibitor Z-VAD and necroptosis inhibitor Nec-1. Further, we found that pyroptosis occurred mainly in macrophages and ferroptosis occured primarily in hepatocytes during steatotic liver IRI. Ferroptosis in heaptocytes and pyroptosis in macrophages are two major cell death types involved in steatotic liver IRI and inhibiting these cell death exerted good protective effects.
    Mesh-Begriff(e) Animals ; Mice ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Hepatocytes/metabolism ; Apoptosis ; Reperfusion Injury/metabolism
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.111545
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5408: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Artikel ; Online: Graphene Oxide Quantum Dots Promote Osteogenic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth via the Wnt/β-Catenin Signaling Pathway

    Xin Yang / Qi Zhao / JingWen Chen / Jiayue Liu / Jiacheng Lin / Jiaxuan Lu / Wenqing Li / Dongsheng Yu / Wei Zhao

    Stem Cells International, Vol

    2021  Band 2021

    Abstract: Graphene oxide quantum dots (GOQDs) are a carbon nanomaterial with broad potential for application in the field of nanomaterial biomedicine. Stem cells from human exfoliated deciduous teeth (SHEDs) play an important role in tissue engineering and ... ...

    Abstract Graphene oxide quantum dots (GOQDs) are a carbon nanomaterial with broad potential for application in the field of nanomaterial biomedicine. Stem cells from human exfoliated deciduous teeth (SHEDs) play an important role in tissue engineering and regenerative medicine. This study investigated the effects of GOQDs on SHED osteogenic differentiation. GOQDs were synthesized; then, the proliferation of SHEDs incubated in GOQDs at different concentrations was evaluated; and the live cells were observed. We observed that live SHEDs incubated in GOQDs emitted green fluorescence in the absence of chemical dyes, and 1, 10, and 50 μg/mL GOQDs significantly promoted SHED proliferation. Culture with the osteogenic induction medium containing 10 μg/mL GOQDs induced calcium nodule formation, increased alkaline phosphatase (ALP) activity, and upregulated SHED mRNA and protein levels of OCN, RUNX2, COL I, and β-catenin. With the addition of Dickkopf 1 (DKK-1) or β-catenin knockdown, expression levels of the above mRNAs and proteins were decreased in GOQD-treated SHEDs. In summary, at a concentration of 10 μg/mL, GOQDs promote SHED proliferation and osteogenic differentiation via the Wnt/β-catenin signaling pathway. This work provides new ideas and fundamental information on interactions between GOQDs and SHEDs that are relevant for the biomedical engineering field.
    Schlagwörter Internal medicine ; RC31-1245
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
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  9. Artikel ; Online: Ancient Herbal Formula Mahuang Lianqiao Chixiaodou Decoction Protects Acute and Acute-on-Chronic Liver Failure via Inhibiting von Willebrand Factor Signaling

    Jiacheng Lin / Qihua Ling / Liang Yan / Bowu Chen / Fang Wang / Yihan Qian / Yueqiu Gao / Qian Wang / Hailong Wu / Xuehua Sun / Yanjun Shi / Xiaoni Kong

    Cells, Vol 11, Iss 3368, p

    2022  Band 3368

    Abstract: Background: Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) are characterized by systemic inflammation and high mortality, but there is no effective clinical treatment. As a classic traditional Chinese medicine (TCM) formula, MaHuang- ... ...

    Abstract Background: Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) are characterized by systemic inflammation and high mortality, but there is no effective clinical treatment. As a classic traditional Chinese medicine (TCM) formula, MaHuang-LianQiao-ChiXiaoDou decoction (MHLQD) has been used clinically for centuries to treat liver diseases. Methods: The LPS/D−GalN-induced ALF mice model and the CCl 4 +LPS/D−GalN-induced ACLF mice model were used to observe the therapeutic effects of MHLQD on mice mortality, hepatocytes death, liver injury, and immune responses. Results: MHLQD treatment significantly improved mice mortality. Liver injury and systemic and hepatic immune responses were also ameliorated after MHLQD treatment. Mechanistically, proteomic changes in MHLQD-treated liver tissues were analyzed and the result showed that the thrombogenic von Willebrand factor (VWF) was significantly inhibited in MHLQD-treated ALF and ACLF models. Histological staining and western blotting confirmed that VWF/RAP1B/ITGB3 signaling was suppressed in MHLQD-treated ALF and ACLF models. Furthermore, mice treated with the VWF inhibitor ADAMTS13 showed a reduced therapeutic effect from MHLQD treatment. Conclusions: Our study indicated that MHLQD is an effective herbal formula for the treatment of ALF and ACLF, which might be attributed to the protection of hepatocytes from death via VWF/RAP1B/ITGB3 signaling.
    Schlagwörter acute liver failure ; acute-on-chronic liver failure ; von Willebrand factor ; traditional Chinese medicine ; herbal therapy ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

    Boning Niu / Jie Liu / Ben Lv / Jiacheng Lin / Xin Li / Chunxiao Wu / Xiaohua Jiang / Zhiping Zeng / Xiao-kun Zhang / Hu Zhou

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 17

    Abstract: Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post- ... ...

    Abstract Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post-translational levels which is relevant to colon cancer stemness, metastasis and resistance to oxaliplatin.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag Nature Portfolio
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