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  1. Artikel ; Online: The effects of advanced glycation end-products on skin and potential anti-glycation strategies.

    Wang, Lingyu / Jiang, Yanfei / Zhao, Chunyue

    Experimental dermatology

    2024  Band 33, Heft 4, Seite(n) e15065

    Abstract: The advanced glycation end-products (AGEs) are produced through non-enzymatic glycation between reducing sugars and free amino groups, such as proteins, lipids or nucleic acids. AGEs can enter the body through daily dietary intake and can also be ... ...

    Abstract The advanced glycation end-products (AGEs) are produced through non-enzymatic glycation between reducing sugars and free amino groups, such as proteins, lipids or nucleic acids. AGEs can enter the body through daily dietary intake and can also be generated internally via normal metabolism and external stimuli. AGEs bind to cell surface receptors for AGEs, triggering oxidative stress and inflammation responses that lead to skin ageing and various diseases. Evidence shows that AGEs contribute to skin dysfunction and ageing. This review introduces the basic information, the sources, the metabolism and absorption of AGEs. We also summarise the detrimental mechanisms of AGEs to skin ageing and other chronic diseases. For the potential strategies for counteracting AGEs to skin and other organs, we summarised the pathways that could be utilised to resist glycation. Chemical and natural-derived anti-glycation approaches are overviewed. This work offers an understanding of AGEs to skin ageing and other chronic diseases and may provide perspectives for the development of anti-glycation strategies.
    Mesh-Begriff(e) Humans ; Maillard Reaction ; Skin ; Oxidative Stress ; Chronic Disease
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland Denmark
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.15065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Memorizing environmental signals through feedback and feedforward loops.

    Jiang, Yanfei / Hao, Nan

    Current opinion in cell biology

    2021  Band 69, Seite(n) 96–102

    Abstract: Cells in diverse organisms can store the information of previous environmental conditions for long periods of time. This form of cellular memory adjusts the cell's responses to future challenges, providing fitness advantages in fluctuating environments. ... ...

    Abstract Cells in diverse organisms can store the information of previous environmental conditions for long periods of time. This form of cellular memory adjusts the cell's responses to future challenges, providing fitness advantages in fluctuating environments. Many biological functions, including cellular memory, are mediated by specific recurring patterns of interactions among proteins and genes, known as 'network motifs.' In this review, we focus on three well-characterized network motifs - negative feedback loops, positive feedback loops, and feedforward loops, which underlie different types of cellular memories. We describe the latest studies identifying these motifs in various molecular processes and discuss how the topologies and dynamics of these motifs can enable memory encoding and storage.
    Mesh-Begriff(e) Feedback ; Feedback, Physiological ; Models, Biological
    Sprache Englisch
    Erscheinungsdatum 2021-02-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2020.11.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2963: Hefte anzeigen Standort:
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  3. Artikel ; Online: Social support and vicarious posttraumatic growth among psychological hotline counselors during COVID-19: the role of resilience and cognitive reappraisal.

    Jiang, Yanfei / Qiao, Tingting / Zhang, Yun / Wu, Yaling / Gong, Yue

    Health psychology and behavioral medicine

    2023  Band 11, Heft 1, Seite(n) 2274550

    Abstract: Background: The COVID-19 pandemic is a serious threat to people's lives and mental health. As a key worker providing psychological assistance services, the purpose of this study was to explore the relationship between social support and vicarious ... ...

    Abstract Background: The COVID-19 pandemic is a serious threat to people's lives and mental health. As a key worker providing psychological assistance services, the purpose of this study was to explore the relationship between social support and vicarious posttraumatic growth of psychological hotline counselors during COVID-19 and its mechanism.
    Methods: A questionnaire survey was conducted among 241 psychological hotline counselors. Path analysis was conducted through structural equation modeling.
    Results: The direct path from social support to vicarious posttraumatic growth of psychological hotline counselors was not significant, but the indirect path between them was significant. Social support can influence vicarious posttraumatic growth of psychological hotline counselors through the mediating effects of resilience and cognitive reappraisal as well as the chain mediating effects of these two factors.
    Conclusions: Social support does not directly stimulate vicarious posttraumatic growth in psychological hotline counselors, but social support can influence counselors' vicarious posttraumatic growth through the role of resilience, cognitive reappraisal, and the chain-mediated effects of psychological resilience and cognitive reappraisal. This encourages hotline counselors to be intentional about applying resources to balance the effects of trauma work on them as they face their clinical work.
    Sprache Englisch
    Erscheinungsdatum 2023-11-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2720684-1
    ISSN 2164-2850 ; 2164-2850
    ISSN (online) 2164-2850
    ISSN 2164-2850
    DOI 10.1080/21642850.2023.2274550
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The Influence of College Students' Empathy on Prosocial Behavior in the COVID-19 Pandemic: The Mediating Role of Social Responsibility.

    Jiang, Yanfei / Yao, Youjuan / Zhu, Xiaoliang / Wang, Shiling

    Frontiers in psychiatry

    2021  Band 12, Seite(n) 782246

    Abstract: Prosocial behavior has played an irreplaceable role during the COVID-19 pandemic, not only in infection prevention and control, but also in improving individual mental health. The current study was conducted after COVID-19 control was under the stage of ... ...

    Abstract Prosocial behavior has played an irreplaceable role during the COVID-19 pandemic, not only in infection prevention and control, but also in improving individual mental health. The current study was conducted after COVID-19 control was under the stage of Ongoing Prevention and Control in China. Using the Interpersonal Response Scale, Prosocial Tendencies Measure and Big Five Personality Questionnaire. In total, 898 college students participated in the current study (
    Sprache Englisch
    Erscheinungsdatum 2021-12-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.782246
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Effects of college students' mindfulness on depression symptoms during the epidemic prevention and control period: The mediating effect of psychological resilience.

    Jiang, Yanfei / Yi, Zhiyu / Yao, Youjuan / Hu, Yanbing / Li, Feilin / Ma, Huizhen

    Frontiers in psychiatry

    2023  Band 13, Seite(n) 991449

    Abstract: Depression symptoms significantly impact college students' mental health, particularly during the "closed management" period during the spread of COVID-19. Exploring the mechanism that affects college students' depression symptoms can help alleviate the ... ...

    Abstract Depression symptoms significantly impact college students' mental health, particularly during the "closed management" period during the spread of COVID-19. Exploring the mechanism that affects college students' depression symptoms can help alleviate the impact of closed management policies on individual mental health and improve their mental health level. The onset of the COVID-19 pandemic resulted in the normalization of epidemic prevention and control in China and the implementation of the dynamic zero-COVID policy. This study used the Five-Factor Mindfulness Questionnaire-Short Form, Psychological Resilience Scale, and Beck Depression Scale to investigate the mindfulness, psychological resilience, and depression symptoms of 1,062 students under closed management conditions at Northwest Normal University. The mindfulness, psychological resilience, and depression status of students in closed management were investigated using an online questionnaire survey. Eight hundred and ten college students (
    Sprache Englisch
    Erscheinungsdatum 2023-01-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.991449
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch ; Online: Evaluating GPT's Programming Capability through CodeWars' Katas

    Zhang, Zizhuo / Wen, Lian / Zhang, Shaoyang / Chen, David / Jiang, Yanfei

    2023  

    Abstract: In the burgeoning field of artificial intelligence (AI), understanding the capabilities and limitations of programming-oriented models is crucial. This paper presents a novel evaluation of the programming proficiency of Generative Pretrained Transformer ( ...

    Abstract In the burgeoning field of artificial intelligence (AI), understanding the capabilities and limitations of programming-oriented models is crucial. This paper presents a novel evaluation of the programming proficiency of Generative Pretrained Transformer (GPT) models, specifically GPT-3.5 and GPT-4, against coding problems of varying difficulty levels drawn from Codewars. The experiments reveal a distinct boundary at the 3kyu level, beyond which these GPT models struggle to provide solutions. These findings led to the proposal of a measure for coding problem complexity that incorporates both problem difficulty and the time required for solution. The research emphasizes the need for validation and creative thinking capabilities in AI models to better emulate human problem-solving techniques. Future work aims to refine this proposed complexity measure, enhance AI models with these suggested capabilities, and develop an objective measure for programming problem difficulty. The results of this research offer invaluable insights for improving AI programming capabilities and advancing the frontier of AI problem-solving abilities.

    Comment: 9 pages
    Schlagwörter Computer Science - Artificial Intelligence ; Computer Science - Software Engineering
    Thema/Rubrik (Code) 006
    Erscheinungsdatum 2023-05-31
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Study of asymmetric biconical fiber tapers for in-fiber Mach-Zehnder interferometers and applications in single-frequency fiber lasers.

    Wang, Dongdong / Jiang, Yanfei / Geng, Xiang / Yang, Bo / Li, Li

    Optics express

    2021  Band 29, Heft 10, Seite(n) 14384–14393

    Abstract: In this paper, asymmetric biconical fiber tapers (ABFTs) for in-fiber Mach-Zehnder interferometers (IFMZIs) are proposed and analyzed to enhance the interference effect. The proposed ABFT-IFMZIs are fabricated, tested, and demonstrated in applications of ...

    Abstract In this paper, asymmetric biconical fiber tapers (ABFTs) for in-fiber Mach-Zehnder interferometers (IFMZIs) are proposed and analyzed to enhance the interference effect. The proposed ABFT-IFMZIs are fabricated, tested, and demonstrated in applications of single-frequency (SF) emissions when incorporated into an all-fiber laser cavity as the frequency selecting component. In comparison with the traditional IFMZIs composed of all symmetric biconical fiber tapers (SBFTs), higher average transmittance and fringe contrast have been demonstrated with the ABFT-based IFMZIs. When applied to the SF fiber laser emission, lower pump threshold and higher slope efficiency have also been confirmed with the ABFT-IFMZI device. The theoretical and experimental results have indicated that the interference effect of IFMZIs can indeed be improved by the designated asymmetry of conical taper angles in ABFTs that can offer an extra flexibility in fiber taper design, fabrication, and applications.
    Sprache Englisch
    Erscheinungsdatum 2021-02-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.419826
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: The Relationship between VEGFC Gene Polymorphisms and Autoimmune Thyroiditis.

    Gao, Chaoqun / Zhu, Jie / Qin, Qiu / Yang, Xiaorong / Jiang, Yanfei / Zhang, Jinan

    BioMed research international

    2022  Band 2022, Seite(n) 2603519

    Abstract: Background: Autoimmune thyroid diseases (AITDs), representative autoimmune diseases, mainly consist of Graves' disease (GD) and Hashimoto's thyroiditis (HT). In this passage, we investigated the association between vascular endothelial growth factor C ( ... ...

    Abstract Background: Autoimmune thyroid diseases (AITDs), representative autoimmune diseases, mainly consist of Graves' disease (GD) and Hashimoto's thyroiditis (HT). In this passage, we investigated the association between vascular endothelial growth factor C (VEGFC) gene polymorphisms and AITDs.
    Methods: A total of 1084 patients with AITDs and 794 healthy controls were tested for VEGFC gene genotypes in four single nucleotide polymorphisms (SNPs) by high-throughput sequencing, and the correlation between VEGFC gene polymorphisms and AITDs was statistically analyzed.
    Results: The genotype distribution of rs3775194 was statistically associated with AITDs compared with the control group. Rs3775194 was associated with AITDs under the overdominant model, both before and after adjusting for confounding factors, while the other three SNPs were not associated with GD and HT. There was a prominent discrepancy between male healthy controls and male AITD patients under overdominant model in rs3775194 and the recessive model in rs11947611. The genotype distribution of rs3775194 was statistically related to male HT.
    Conclusion: These results reveal the correlation between VEGFC mutation and AITD susceptibility.
    Mesh-Begriff(e) Alleles ; Case-Control Studies ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Graves Disease/genetics ; Hashimoto Disease/genetics ; Humans ; Male ; Polymorphism, Single Nucleotide/genetics ; Thyroiditis, Autoimmune/genetics ; Vascular Endothelial Growth Factor C/genetics
    Chemische Substanzen VEGFC protein, human ; Vascular Endothelial Growth Factor C
    Sprache Englisch
    Erscheinungsdatum 2022-07-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/2603519
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Hydroxychloroquine use reduces mortality risk in systemic lupus erythematosus: A systematic review and meta-analysis of cohort studies.

    Cai, Tiantian / Zhao, Jing / Yang, Yanping / Jiang, Yanfei / Zhang, Jin-An

    Lupus

    2022  Band 31, Heft 14, Seite(n) 1714–1725

    Abstract: Objective: Hydroxychloroquine (HCQ) is widely used in patients with systemic lupus erythematosus (SLE), but its effects on the mortality have not reached a definite conclusion. In this systematic review and meta-analysis, we aimed to assess whether HCQ ... ...

    Abstract Objective: Hydroxychloroquine (HCQ) is widely used in patients with systemic lupus erythematosus (SLE), but its effects on the mortality have not reached a definite conclusion. In this systematic review and meta-analysis, we aimed to assess whether HCQ use could reduce the risk of mortality in SLE patients.
    Methods: PubMed, Embase, Web of Science, and Cochrane database were searched from inception to April 17, 2022 without language restrictions to explore the relationship between HCQ use and SLE mortality. The relative risk (HR) was pooled using the STATA software.
    Results: A total of 21 studies with a pooled patient population of 26,037 were included in the study, including 14 studies on the association between HCQ alone and mortality risk and seven studies on the association between HCQ/chloroquine (CQ) and mortality risk. The pooled findings suggested that HCQ significantly reduced the overall mortality risk of SLE (pooled HR 0.46, 95% CI 0.38-0.57,
    Conclusion: Our data suggested that HCQ use was associated with a reduced risk of mortality in patients with SLE.
    Mesh-Begriff(e) Humans ; Hydroxychloroquine/therapeutic use ; Lupus Erythematosus, Systemic/complications ; Antirheumatic Agents/therapeutic use ; Chloroquine/therapeutic use ; Cohort Studies
    Chemische Substanzen Hydroxychloroquine (4QWG6N8QKH) ; Antirheumatic Agents ; Chloroquine (886U3H6UFF)
    Sprache Englisch
    Erscheinungsdatum 2022-11-03
    Erscheinungsland England
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033221129774
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Proteomic analysis of urinary exosomes reveals ferroptosis-associated proteins are involved in diabetic nephropathy.

    Mu, Kaida / Yang, Yanping / An, Xiaofei / Zhu, Jie / Zhang, Jing / Jiang, Yanfei / Yang, Xiaorong / Zhang, Jinan

    Genes & diseases

    2023  Band 11, Heft 5, Seite(n) 101138

    Sprache Englisch
    Erscheinungsdatum 2023-11-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.101138
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