Artikel ; Online: Immunogenicity of poxvirus-based vaccines against Nipah virus.
2023 Band 13, Heft 1, Seite(n) 11384
Abstract: Nipah virus (NiV), an emerging zoonotic pathogen in Southeast Asia, is transmitted from Pteropus species of fruit bats to a wide range of species, including humans, pigs, horses, dogs, and cats. NiV has killed millions of animals and caused highly fatal ... ...
| Abstract | Nipah virus (NiV), an emerging zoonotic pathogen in Southeast Asia, is transmitted from Pteropus species of fruit bats to a wide range of species, including humans, pigs, horses, dogs, and cats. NiV has killed millions of animals and caused highly fatal human outbreaks since no vaccine is commercially available. This study characterized the immunogenicity and safety of poxvirus-based Nipah vaccines that can be used in humans and species responsible for NiV transmission. Mice were vaccinated with modified vaccinia Ankara (MVA) and raccoon pox (RCN) viral vectors expressing the NiV fusion (F) and glycoprotein (G) proteins subcutaneously (SC) and intranasally (IN). Importantly, both vaccines did not induce significant weight loss or clinical signs of disease while generating high circulating neutralizing antibodies and lung-specific IgG and IgA responses. The MVA vaccine saw high phenotypic expression of effector and tissue resident memory CD8ɑ |
|---|---|
| Mesh-Begriff(e) | Animals ; Humans ; Cats ; Mice ; Dogs ; Swine ; Horses ; Nipah Virus ; Viral Vaccines ; Poxviridae ; Vaccinia virus/genetics ; Genetic Vectors/genetics ; Antibodies, Viral |
| Chemische Substanzen | Viral Vaccines ; Antibodies, Viral |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-07-14 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-023-38010-2 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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