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  1. Artikel: A prospective randomized double-blind study comparing the dose-response curves of epidural ropivacaine for labor analgesia initiation between parturients with and without obesity.

    Huang, Xiao-Dong / Qiu, Xiao-Xiao / Wang, He-Jie / Jin, Xia-Fang / Xiao, Fei

    Frontiers in pharmacology

    2024  Band 15, Seite(n) 1348700

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1348700
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Dose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron.

    Sun, Xiao-Xia / Qian, Jing / Fan, Jia-Ming / Liu, Lin / Jin, Xia-Fang / Xiao, Fei

    Drug design, development and therapy

    2024  Band 18, Seite(n) 1459–1467

    Abstract: Background: Ondansetron reduces the median effective dose (ED50) of prophylactic phenylephrine to prevent spinal-induced hypotension (SIH) during cesarean delivery. However, the exact dose response of phenylephrine in combination with prophylactic ... ...

    Abstract Background: Ondansetron reduces the median effective dose (ED50) of prophylactic phenylephrine to prevent spinal-induced hypotension (SIH) during cesarean delivery. However, the exact dose response of phenylephrine in combination with prophylactic ondansetron for preventing SIH is unknown. Therefore, this study aimed to determine the dose-response of phenylephrine to prevent SIH in cesarean delivery when 4 mg of ondansetron was used as a preventive method.
    Methods: A total of 80 parturients were enrolled and divided randomly into four groups (n = 20 in each group) who received either 0.2, 0.3, 0.4, or 0.5 μg/kg/min of prophylactic phenylephrine. Ten minutes before the initiation of spinal induction, 4 mg prophylactic ondansetron was administered. The effective dose of prophylactic phenylephrine was defined as the dose required to prevent hypotension after the period of intrathecal injection and up to neonatal delivery. The ED50 and ED90 of prophylactic phenylephrine and 95% confidence intervals (95% CI) were calculated using probit analysis.
    Results: The ED50 and ED90 for prophylactic phenylephrine to prevent SIH were 0.25 (95% CI, 0.15 to 0.30), and 0.45 (95% CI, 0.39 to 0.59) μg/kg/min, respectively. No significant differences were observed in the side effects and neonatal outcomes between the four groups.
    Conclusion: The administration of 4 mg of prophylactic ondansetron was associated with an ED50 of 0.25 (95% CI, 0.15~0.30) and ED90 of 0.45 (95% CI, 0.39~0.59) μg/kg/min for phenylephrine to prevent SIH.
    Mesh-Begriff(e) Adult ; Female ; Humans ; Pregnancy ; Anesthesia, Epidural ; Anesthesia, Spinal/adverse effects ; Cesarean Section ; Dose-Response Relationship, Drug ; Hypotension/prevention & control ; Hypotension/chemically induced ; Ondansetron/administration & dosage ; Phenylephrine/administration & dosage
    Chemische Substanzen Ondansetron (4AF302ESOS) ; Phenylephrine (1WS297W6MV)
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland New Zealand
    Dokumenttyp Case Reports ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S452983
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: TCF21

    Wang, Jian-Guo / Jin, Xia-Fang / Huang, Yi-Min / Xu, Zheng-Fen / Huang, Shou-Ju / Zhu, Yingjie / Ai, Ling / Hang, Tian

    Biomarkers in medicine

    2024  Band 17, Heft 17, Seite(n) 693–699

    Abstract: Aims: ...

    Abstract Aims:
    Mesh-Begriff(e) Humans ; Case-Control Studies ; Genotype ; Polymorphism, Single Nucleotide ; Colorectal Neoplasms/genetics ; China ; Basic Helix-Loop-Helix Transcription Factors/genetics
    Chemische Substanzen TCF21 protein, human ; Basic Helix-Loop-Helix Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2024-01-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2022-0750
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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