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  1. Artikel ; Online: Shake it off: A curious case of rigors.

    Han, Shannon / John, Sherin / Jackson, Christopher D

    Journal of the National Medical Association

    2023  Band 115, Heft 3, Seite(n) 333–336

    Abstract: Heparin-induced Anaphylactoid reactions are rare systemic reactions to heparin exposure. Although the exact pathogenesis of the reaction is unclear, in vivo platelet activation from inflammation may play a role. The reaction involves anti-platelet factor ...

    Abstract Heparin-induced Anaphylactoid reactions are rare systemic reactions to heparin exposure. Although the exact pathogenesis of the reaction is unclear, in vivo platelet activation from inflammation may play a role. The reaction involves anti-platelet factor 4, a common factor also noted to be involved in heparin-induced thrombocytopenia (HIT). Like HIT, prompt identification of the reaction, immediate discontinuation of heparin, and supportive care are the mainstays of treatment to avoid severe and potentially fatal outcomes. Previous cases have described heparin-induced anaphylactoid reactions in the setting of heparin-induced thrombocytopenia. However, we will present a case of an isolated heparin-induced anaphylactoid reaction without HIT.
    Mesh-Begriff(e) Humans ; Anticoagulants/adverse effects ; Anaphylaxis/chemically induced ; Anaphylaxis/complications ; Heparin/adverse effects ; Thrombocytopenia/chemically induced ; Thrombocytopenia/diagnosis
    Chemische Substanzen Anticoagulants ; Heparin (9005-49-6)
    Sprache Englisch
    Erscheinungsdatum 2023-04-21
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 419737-9
    ISSN 1943-4693 ; 0027-9684
    ISSN (online) 1943-4693
    ISSN 0027-9684
    DOI 10.1016/j.jnma.2023.03.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: IFPACS: Creating a Global Federation of Physician Assistant and Comparable Students.

    Showstark, Mary / Hix, Lea R / Kereto, Leshan / John, Sherin / Uakkas, Saad / Berkowitz, Oren

    The journal of physician assistant education : the official journal of the Physician Assistant Education Association

    2021  Band 32, Heft 1, Seite(n) 65–69

    Mesh-Begriff(e) Humans ; Physician Assistants/education ; Students
    Sprache Englisch
    Erscheinungsdatum 2021-02-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2620682-1
    ISSN 1941-9449 ; 1941-9430
    ISSN (online) 1941-9449
    ISSN 1941-9430
    DOI 10.1097/JPA.0000000000000346
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Relationship between serum homocysteine levels and depressive symptoms: the Cooper Center Longitudinal Study.

    Gu, Phillip / DeFina, Laura F / Leonard, David / John, Sherin / Weiner, Myron F / Brown, E Sherwood

    The Journal of clinical psychiatry

    2012  Band 73, Heft 5, Seite(n) 691–695

    Abstract: Objective: Elevated serum levels of the amino acid homocysteine (HCY) are associated with a variety of diseases. To resolve conflicting findings in studies that suggest a relationship between elevated serum HCY levels and depression, we examined the ... ...

    Abstract Objective: Elevated serum levels of the amino acid homocysteine (HCY) are associated with a variety of diseases. To resolve conflicting findings in studies that suggest a relationship between elevated serum HCY levels and depression, we examined the relationship between HCY levels and depressive symptoms in the largest sample studied to date.
    Method: We conducted a cross-sectional study of 11,757 participants (68.9% men) aged 20 to 90 years who completed preventive health examinations at the Cooper Clinic, Dallas, Texas, from 2007 to 2010. Currently experiencing depression was defined as a 10-item Center for Epidemiologic Studies Depression Scale (CES-D) score of ≥ 10. Serum HCY levels were obtained. Data were analyzed in a multiple logistic regression model of CES-D score of ≥ 10.
    Results: When controlling for age, sex, body mass index, exercise, education, smoking, antidepressant use, creatinine level, alcohol use, and chronic medical conditions, elevated HCY was associated with 26% greater odds of currently experiencing depressive symptoms (P = .007) as defined by CES-D score.
    Conclusions: In the largest sample examined to date, we found a significant positive relationship between elevated serum HCY levels and currently experiencing depressive symptoms. Given the cross-sectional nature of the study, it is not possible to determine the direction of the relationship or whether lowering HCY levels will ameliorate depressive symptoms. Thus, longitudinal studies are needed.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Depression/blood ; Depression/epidemiology ; Homocysteine/blood ; Humans ; Linear Models ; Logistic Models ; Middle Aged ; Multivariate Analysis ; Sex Distribution ; Texas/epidemiology
    Chemische Substanzen Homocysteine (0LVT1QZ0BA)
    Sprache Englisch
    Erscheinungsdatum 2012-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.11m07223
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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