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  1. Artikel ; Online: A kinase-independent role for CDK8 in BCR-ABL1+ leukemia

    Ingeborg Menzl / Tinghu Zhang / Angelika Berger-Becvar / Reinhard Grausenburger / Gerwin Heller / Michaela Prchal-Murphy / Leo Edlinger / Vanessa M. Knab / Iris Z. Uras / Eva Grundschober / Karin Bauer / Mareike Roth / Anna Skucha / Yao Liu / John M. Hatcher / Yanke Liang / Nicholas P. Kwiatkowski / Daniela Fux / Andrea Hoelbl-Kovacic /
    Stefan Kubicek / Junia V. Melo / Peter Valent / Thomas Weichhart / Florian Grebien / Johannes Zuber / Nathanael S. Gray / Veronika Sexl

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 15

    Abstract: Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling ...

    Abstract Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling induces apoptosis in these cells.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-10-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: A kinase-independent role for CDK8 in BCR-ABL1+ leukemia

    Ingeborg Menzl / Tinghu Zhang / Angelika Berger-Becvar / Reinhard Grausenburger / Gerwin Heller / Michaela Prchal-Murphy / Leo Edlinger / Vanessa M. Knab / Iris Z. Uras / Eva Grundschober / Karin Bauer / Mareike Roth / Anna Skucha / Yao Liu / John M. Hatcher / Yanke Liang / Nicholas P. Kwiatkowski / Daniela Fux / Andrea Hoelbl-Kovacic /
    Stefan Kubicek / Junia V. Melo / Peter Valent / Thomas Weichhart / Florian Grebien / Johannes Zuber / Nathanael S. Gray / Veronika Sexl

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 15

    Abstract: Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling ...

    Abstract Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling induces apoptosis in these cells.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-10-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Zusatzmaterialien

    Kategorien

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