LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 82

Search options

  1. Book ; Thesis: Vergleichende Untersuchungen zwischen der elektrischen Zahnbürste Rotamed und einer Handzahnbürste

    Köster, Frank

    1988  

    Size 70 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 1988
    HBZ-ID HT003357437
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    89 D 5457 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Prevalence of PD-L1 in Cervical Cancer Patients and the Potential for Combining an Immune Checkpoint Inhibitor With Lenvatinib.

    Bräutigam, Karen / Schmidt, Talina / Baur, Meike / Tauber, Nikolas / Kontomanolis, Emmanuel N / Hemptenmacher, Franziska / Rody, Achim / Köster, Frank

    Anticancer research

    2024  Volume 44, Issue 2, Page(s) 503–510

    Abstract: Background/aim: Cervical cancer is the fourth most common cause of cancer-related deaths in women worldwide. The potential for targeted therapy against the immune checkpoint programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) and receptor ... ...

    Abstract Background/aim: Cervical cancer is the fourth most common cause of cancer-related deaths in women worldwide. The potential for targeted therapy against the immune checkpoint programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) and receptor tyrosine kinases was examined in cervical cancer patients and cell lines.
    Materials and methods: On tissue microarrays, PD-L1 was analyzed in 123 samples of patients with cervical cancer using immunohistochemistry. In SiHa, HeLa, and CaSki cervical cancer cell lines we examined the combination of lenvatinib with a PD-1/PD-L1 inhibitor using cell viability assays, the activation of cell signaling pathway proteins using western blots and gene expression using quantitative reverse transcriptase-PCR.
    Results: Of 113 evaluable samples, 90 (79.6%) had more than 1% PD-L1 positive cells. The single treatment with the PD-1/PD-L1 inhibitor resulted in the greatest reduction in growth for CaSki and lenvatinib in HeLa cells. In contrast, the combined treatment of lenvatinib with the PD-1/PD-L1 inhibitor demonstrated a significantly stronger impeded proliferation compared to the single treatment in all three cell lines. Moreover, the combined treatment caused significantly less phosphorylation of the signaling molecules ERK and S6 in SiHa and of S6 and STAT3 in HeLa cells but not in CaSki. All treatments diminished the mRNA levels of PD-L1, Il-8, and FGFR in SiHa cells.
    Conclusion: PD1 is frequently expressed in cervical cancer samples. Combining lenvatinib with a PD-1/PD-L1 inhibitor diminished proliferation of cervical cancer cell lines. Consequently, this combination might be a promising option to treat cervical cancer. Signaling pathways involved in tumor cell growth are blocked by the combined treatment but still a model of the underlying mechanism cannot be drawn.
    MeSH term(s) Female ; Humans ; B7-H1 Antigen/metabolism ; HeLa Cells ; Immune Checkpoint Inhibitors/therapeutic use ; Phenylurea Compounds ; Prevalence ; Programmed Cell Death 1 Receptor ; Quinolines ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/genetics
    Chemical Substances B7-H1 Antigen ; Immune Checkpoint Inhibitors ; lenvatinib (EE083865G2) ; Phenylurea Compounds ; Programmed Cell Death 1 Receptor ; Quinolines
    Language English
    Publishing date 2024-02-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16838
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: The InflateSAR Campaign: Testing SAR Vessel Detection Systems for Refugee Rubber Inflatables

    Lanz, Peter / Marino, Armando / Brinkhoff, Thomas / Köster, Frank / Möller, Matthias

    Remote Sensing. 2021 Apr. 13, v. 13, no. 8

    2021  

    Abstract: Countless numbers of people lost their lives at Europe’s southern borders in recent years in the attempt to cross to Europe in small rubber inflatables. This work examines satellite-based approaches to build up future systems that can automatically ... ...

    Abstract Countless numbers of people lost their lives at Europe’s southern borders in recent years in the attempt to cross to Europe in small rubber inflatables. This work examines satellite-based approaches to build up future systems that can automatically detect those boats. We compare the performance of several automatic vessel detectors using real synthetic aperture radar (SAR) data from X-band and C-band sensors on TerraSAR-X and Sentinel-1. The data was collected in an experimental campaign where an empty boat lies on a lake’s surface to analyse the influence of main sensor parameters (incidence angle, polarization mode, spatial resolution) on the detectability of our inflatable. All detectors are implemented with a moving window and use local clutter statistics from the adjacent water surface. Among tested detectors are well-known intensity-based (CA-CFAR), sublook-based (sublook correlation) and polarimetric-based (PWF, PMF, PNF, entropy, symmetry and iDPolRAD) approaches. Additionally, we introduced a new version of the volume detecting iDPolRAD aimed at detecting surface anomalies and compare two approaches to combine the volume and the surface in one algorithm, producing two new highly performing detectors. The results are compared with receiver operating characteristic (ROC) curves, enabling us to compare detectors independently of threshold selection.
    Keywords algorithms ; angle of incidence ; boats ; entropy ; lakes ; rubber ; satellites ; statistics ; synthetic aperture radar ; Europe
    Language English
    Dates of publication 2021-0413
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs13081487
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book ; Online ; Thesis: Medikamentöser Einfluss auf die epithelial-mesenchymale Transition bei triple-negativen Brustkrebszelllinien

    Stelbrink, Johanna Susanne [Verfasser] / Köster, Frank [Akademischer Betreuer] / Bernd, Heinz-Wolfram [Akademischer Betreuer]

    2022  

    Author's details Johanna Susanne Stelbrink ; Akademische Betreuer: Frank Köster, Heinz-Wolfram Bernd
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book ; Online: Extraction and Analysis of Highway On-Ramp Merging Scenarios from Naturalistic Trajectory Data

    Klitzke, Lars / Gimm, Kay / Koch, Carsten / Köster, Frank

    2021  

    Abstract: Connected and Automated Vehicles (CAVs) are envisioned to transform the future industrial and private transportation sectors. However, due to the system's enormous complexity, functional verification and validation of safety aspects are essential before ... ...

    Abstract Connected and Automated Vehicles (CAVs) are envisioned to transform the future industrial and private transportation sectors. However, due to the system's enormous complexity, functional verification and validation of safety aspects are essential before the technology merges into the public domain. Therefore, in recent years, a scenario-driven approach has gained acceptance, emphasizing the requirement of a solid data basis of scenarios. The large-scale research facility Test Bed Lower Saxony (TFNDS) enables the provision of ample information for a database of scenarios on highways. For that purpose, however, the scenarios of interest must be identified and extracted from the collected Naturalistic Trajectory Data (NTD). This work addresses this problem and proposes a methodology for onramp scenario extraction, enabling scenario categorization and assessment. An Hidden Markov Model (HMM) and Dynamic Time Warping (DTW) is utilized for extraction and a decision tree with the Surrogate Measure of Safety (SMoS) Post Enroachment Time (PET) for categorization and assessment. The efficacy of the approach is shown with a dataset of NTD collected on the TFNDS.

    Comment: 7 pages
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Computer Science - Robotics ; I.2.8 ; I.5.4 ; I.6.5
    Subject code 006
    Publishing date 2021-04-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Book ; Online ; Thesis: Die Regulation von Wachstumsarrest und Zellmigration in Zellen des duktalen Pankreasadenokarzinoms durch die kleine GTPase RAC1B

    Otterbein, Hannah [Verfasser] / Ungefroren, Hendrik [Akademischer Betreuer] / Köster, Frank [Akademischer Betreuer]

    2022  

    Author's details Hannah Otterbein ; Akademische Betreuer: Hendrik Ungefroren, Frank Köster
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Entwicklung eines konzeptionellen Frameworks für Elektromobilitätskonzepte mit dem Fokus auf Geschäftsmodellen sowie IKT

    Osmani, Hewad / Köster, Frank / Wagner vom Berg, Benjamin

    Nachhaltige betriebliche Umweltinformationssysteme : Konferenzband zu den 9. BUIS-Tagen , p. 253-268

    2018  , Page(s) 253–268

    Author's details Hewad Osmani, Benjamin Wagner vom Berg, Frank Köster
    Language German
    Publisher Springer Gabler
    Publishing place Wiesbaden
    Document type Article
    ISBN 3-658-20379-X ; 978-3-658-20379-5
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: The InflateSAR Campaign: Evaluating SAR Identification Capabilities of Distressed Refugee Boats

    Lanz, Peter / Marino, Armando / Brinkhoff, Thomas / Köster, Frank / Möller, Matthias

    Remote Sensing. 2020 Oct. 27, v. 12, no. 21

    2020  

    Abstract: Most of the recent research in the field of marine target detection has been concentrating on ships with large metallic parts. The focus of this work is on much more challenging targets represented by small rubber inflatables. They are of importance, ... ...

    Abstract Most of the recent research in the field of marine target detection has been concentrating on ships with large metallic parts. The focus of this work is on much more challenging targets represented by small rubber inflatables. They are of importance, since in recent years they have largely been used by migrants to cross the Mediterranean Sea between Libya and Europe. The motivation of this research is to mitigate the ongoing humanitarian crisis at Europe’s southern borders. These boats, packed with up to 200 people, are in no way suitable to cross the Mediterranean Sea or any other big water body and are in distress from the moment of departure. The establishment of a satellite-based surveillance infrastructure could considerably support search and rescue missions in the Mediterranean Sea, reduce the number of such boats being missed and mitigate the ongoing death in the open ocean. In this work we describe and analyze data from the InflateSAR acquisition campaign, wherein we gathered multiple-platform SAR imagery of an original refugee inflatable. The test site for this campaign is a lake which provides background clutter that is more predictable. The analysis considered a sum of experiments, enabling investigations of a broad range of scene settings, such as the vessel’s orientation, superstructures and speed. We assess their impact on the detectability of the chosen target under different sensor parameters, such as polarimetry, resolution and incidence angle. Results show that TerraSAR-X Spotlight and Stripmap modes offer good capabilities to potentially detect those types of boats in distress. Low incidence angles and cross-polarization decrease the chance of a successful identification, whereas a fully occupied inflatable, orthogonally oriented to the line of sight, seems to be better visible than an empty one. The polarimetric analyses prove the vessel’s different polarimetric behavior in comparison with the water surface, especially when it comes to entropy. The analysis considered state-of-the-art methodologies with single polarization and dual polarization channels. Finally, different metrics are used to discuss whether and to which extent the results are applicable to other open ocean datasets. This paper does not introduce any vessel detection or classification algorithm from SAR images. Rather, its results aim at paving the way to the design and the development of a specially tailored detection algorithm for small rubber inflatables.
    Keywords algorithms ; angle of incidence ; boats ; classification ; concentrating ; data analysis ; data collection ; death ; design ; detection ; distress ; entropy ; infrastructure ; lakes ; monitoring ; motivation ; paper ; people ; polarimetry ; remote sensing ; research ; rubber ; satellites ; ships ; surface water ; Europe ; Libya ; Mediterranean Sea
    Language English
    Dates of publication 2020-1027
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs12213516
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix.

    Bräutigam, Karen / Meier, Stefanie / Meneder, Sabina / Proppe, Louisa / Stroschein, Katharina / Polack, Stephan / Köster, Frank / Rody, Achim / Baum, Sascha

    Cancers

    2022  Volume 14, Issue 13

    Abstract: Background: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections.: Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from ...

    Abstract Background: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections.
    Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from 509 patients visiting our dysplasia consultation clinic. HPV genotyping was performed using the EUROArray HPV test.
    Results: Positivity of HR HPV was found in 60.4-64.3% of anogenital and 14.6% of oral samples. HPV 16 showed the highest incidence in all investigated areas. In cervical and vaginal samples HPV 31 was detected second most, while in vulvar, anal, and oral samples HPV 53 was the second most common subtype. HPV 18 was found lower in all areas, while HPV 51, HPV 52, and HPV 73 were detected higher than expected from published data. A good concordance between cervical, vaginal and vulvar samples was examined for most of the HPV. HR HPV infection was higher in cervical cancer (CC; 91.7%) and high-grade intraepithelial squamous lesions (HSIL; 93.9%) compared to low-grade SIL (LSIL; 69.6%) and normal samples (44.8%).
    Conclusion: In addition to the well described HPV subtypes, we found others with high incidences in the investigated areas which may be evident for HSIL and CC of those areas.
    Language English
    Publishing date 2022-06-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14133136
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book ; Online ; Thesis: Vergleichende Proteomanalyse zwischen Colitis Ulcerosa assoziierten und sporadischen kolorektalen Karzinomen nach Laser Capture Mikrodissektion

    Kollbeck, Sophie L. G. [Verfasser] / Habermann, Jens [Akademischer Betreuer] / Köster, Frank [Gutachter]

    Comparative proteomic analysis of Ulcerative Colitis associated and Sporadic Colorectal Cancer after Laser Capture Microdissection

    2020  

    Author's details Sophie L. G. Kollbeck ; Gutachter: Frank Köster ; Akademischer Betreuer: Jens Habermann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top